Abstract:
:Brain alcohol was measured in rhesus monkeys (Macaca mulatta) by proton magnetic resonance spectroscopy (MRS) following acute nasogastric alcohol administration (0.8 g/kg). Monkeys were anesthetized with ketamine and xylazine. A 1.5 T whole body imager and a 3-inch surface coil were used to acquire TE 30 and 270 ms spectra from a 7.5 cc voxel localized with a stimulated echo (STEAM) sequence. Venous blood samples were collected during spectral acquisitions for gas chromatographic determination of temporally concordant blood alcohol levels (BALs). Acute alcohol administration did not alter the resonance areas of N-acetylaspartate/N-acetyl containing compounds (NAA), choline containing compounds, or total creatine. The NAA resonance was used as an internal standard to calculate approximate brain alcohol concentrations, which averaged 27 +/- 3% and 27 +/- 8% of temporally concordant BALs (T2-corrected TE 30 and TE 270 ms spectra, respectively). In addition to reconfirming results from prior studies finding incomplete detection of brain alcohol with MRS, these results demonstrate the feasibility of measuring brain alcohol in anesthetized nonhuman primates to examine relationships between alcohol exposure history and MRS-visibility of brain alcohol.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Kaufman MJ,Chiu TM,Mendelson JH,Woods BT,Mello NK,Lukas SE,Fivel PA,Wighton LGdoi
10.1016/0730-725x(94)90089-asubject
Has Abstractpub_date
1994-01-01 00:00:00pages
1245-53issue
8eissn
0730-725Xissn
1873-5894pii
0730-725X(94)90089-Ajournal_volume
12pub_type
杂志文章abstract::Functional magnetic resonance imaging (fMRI) research has shown that brain arteriovenous malformations (AVMs) lead to reorganization of cortical motor areas. Since it is known that blood oxygenation level-dependent signal in fMRI may be influenced by the hemodynamic perturbation associated with the presence of the AVM...
journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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更新日期:2008-10-01 00:00:00
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journal_title:Magnetic resonance imaging
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更新日期:2006-05-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(87)90023-3
更新日期:1987-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章,多中心研究
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更新日期:1993-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(01)00396-4
更新日期:2001-07-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.07.012
更新日期:2011-11-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2008.02.018
更新日期:2008-09-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(99)00008-9
更新日期:1999-06-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(87)90481-4
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.mri.2010.03.046
更新日期:2010-11-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(85)90358-3
更新日期:1985-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2013.10.004
更新日期:2014-02-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2016.12.006
更新日期:2017-05-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2010.03.023
更新日期:2010-10-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(94)00096-l
更新日期:1995-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(97)00251-8
更新日期:1998-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/s0730-725x(96)00348-7
更新日期:1997-01-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2019.09.012
更新日期:2020-04-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(89)90550-x
更新日期:1989-05-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/s0730-725x(00)00125-9
更新日期:2000-04-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2015.12.024
更新日期:2016-05-01 00:00:00
abstract::The purpose of this study was to evaluate the effect of gadoxetic acid (Gd-EOB-DTPA) on measurements of liver stiffness by using magnetic resonance elastography (MRE). In this study, 104 consecutive patients (mean age, 67.7±9.4 years) underwent MRE using a 1.5-T MR scanner equipped with a cylindrical passive driver th...
journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2011.08.005
更新日期:2012-01-01 00:00:00