Impact of maternal diabetes mellitus on mortality and morbidity of preterm infants (24-33 weeks' gestation).

Abstract:

OBJECTIVE:We hypothesized that maternal diabetes mellitus (DM) increases the risk for mortality, respiratory distress syndrome (RDS), and major complications of prematurity. METHODS:Analysis of prospectively collected (1995-2007) Israel National Very Low Birth Weight Infant Database. Maternal DM was recorded as pregestational or gestational. Multivariable logistic regression analysis was used to assess the independent effect of maternal DM status on infant mortality, RDS, and other complications of prematurity. RESULTS:Infants of mothers with pregestational (n = 120) and gestational (n = 825) DM were similar, and their data were pooled for analyses. Mothers with DM were more likely to have received a complete course of prenatal steroids than control mothers. Infants of diabetic mothers (IDM) had a slightly higher gestational age and birthweight than non-IDM's. Distribution of birthweight percentiles and the mean birthweight z scores were similar. Apgar scores were statistically higher in the IDM group. There were no significant differences between the 2 groups in terms of delivery room mortality, RDS, and other major complications of prematurity. Total mortality and bronchopulmonary dysplasia rates were significantly higher in the nondiabetic group. The adjusted odds ratios for mortality, RDS, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia, retinopathy of prematurity, necrotizing enterocolitis, and patent ductus arteriosus were not significantly increased in the IDM group. CONCLUSIONS:With modern management and adequate prenatal care, IDM born very low birthweight do not seem to be at an excess risk of developing RDS or other major complications of prematurity compared with non-IDM.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Bental Y,Reichman B,Shiff Y,Weisbrod M,Boyko V,Lerner-Geva L,Mimouni FB,Collaboration With the Israel Neonatal Network.

doi

10.1542/peds.2010-3443

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

e848-55

issue

4

eissn

0031-4005

issn

1098-4275

pii

peds.2010-3443

journal_volume

128

pub_type

杂志文章
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    更新日期:2008-09-01 00:00:00

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    authors: Shapiro GG,Virant FS,Furukawa CT,Pierson WE,Bierman CW

    更新日期:1991-03-01 00:00:00

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    更新日期:2008-12-01 00:00:00

  • Homogeneous clinical subgroups in children with Tourette syndrome.

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    pub_type: 杂志文章

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    authors: Barabas G,Matthews WS

    更新日期:1985-01-01 00:00:00

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    doi:

    authors: Johnson CE,DeBaz BP,Shurin PA,DeBartolomeo R

    更新日期:1986-11-01 00:00:00

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    doi:

    authors: Drotar D,Doershuk CF,Stern RC,Boat TF,Boyer W,Matthews L

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  • First case of human infection caused by Pasteurella gallinarum causing infective endocarditis in an adolescent 10 years after surgical correction for truncus arteriosus.

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    pub_type: 杂志文章,评审

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    更新日期:1995-06-01 00:00:00

  • Maternal mosaicism confounds the neonatal diagnosis of type 1 Timothy syndrome.

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    pub_type: 杂志文章

    doi:10.1542/peds.2012-2941

    authors: Dufendach KA,Giudicessi JR,Boczek NJ,Ackerman MJ

    更新日期:2013-06-01 00:00:00

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    pub_type: 杂志文章

    doi:

    authors: Mandell F,Wright PF

    更新日期:1975-01-01 00:00:00

  • Intractable diarrhea from cytomegalovirus enterocolitis in an immunocompetent infant.

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    更新日期:1999-01-01 00:00:00

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    authors: Hannan EL,Racz M,Kavey RE,Quaegebeur JM,Williams R

    更新日期:1998-06-01 00:00:00

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    更新日期:1982-07-01 00:00:00

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