Homogeneous clinical subgroups in children with Tourette syndrome.

Abstract:

:The existence of two clinically homogeneous subgroups in Tourette syndrome, depending upon the presence or absence of migraine or a family history of migraine, is suggested. Patients with Tourette syndrome who have migraine (n = 18) were found to have a significantly higher prevalence of disorders of arousal--particularly sleepwalking and night terrors--as well as a higher prevalence of motion sickness than patients without migraine (n = 27). They were also significantly more likely to exhibit a co-occurrence of associated features (two or more) than the patients without migraine. Patients with Tourette syndrome who have not had migraine headaches but in whom there is a family history for migraine (n = 20) were shown to have an intermediate prevalence of associated symptoms. It is suggested that the differential association for these symptoms in patients with Tourette syndrome may reflect an underlying abnormality in function of two different neurotransmitter systems.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Barabas G,Matthews WS

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

73-5

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

75

pub_type

杂志文章
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