The Maternal Phenylketonuria Project: a summary of progress and challenges for the future.

Abstract:

:The results of the International Collaborative Study of Maternal phenylketonuria have shown that dietary phenylalanine restriction of women with hyperphenylalaninemia during pregnancy decreases the incidence of mental retardation, microcephaly, congenital heart disease, and intrauterine growth retardation in their offspring. The best results are achieved when treatment is initiated before conception. Psychosocial problems are the most pervasive obstacle to the achievement of optimum dietary treatment. Novel, nondietary approaches to the treatment of maternal phenylketonuria are under development.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Clarke JT

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

1584-7

issue

6 Pt 2

eissn

0031-4005

issn

1098-4275

journal_volume

112

pub_type

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