Flunisolide aerosol for treatment of severe, chronic asthma in steroid-independent children.

Abstract:

:The efficacy and safety of flunisolide aerosol were studied in 46 steroid-independent children with asthma inadequately controlled by nonsteroid drugs. This was a double-blind, placebo-controlled, parallel study lasting eight weeks. Patients were randomly assigned either flunisolide by inhalation, 0.5 mg twice a day, or placebo. Effectiveness was evaluated daily by symptom scores, by Wright peak flow measurements twice daily, and weekly by spirometry and physical examination. Adrenal function and throat cultures for Candida were evaluated before and after the test-drug treatment period. Flunisolide was administered to 25 patients and 21 received placebo. Most symptom scores were statistically significantly better in flunisolide-treated than in placebo-treated patients; these included severity of wheezing (P = .01), chest tightness (P = .01) and shortness of breath (P = .02), and frequency (P = .001) and severity of asthma attacks (P = .03). In addition, placebo-treated patients used significantly more bronchodilators than flunisolide-treated patients. In the final therapeutic effectiveness evaluation, 72% of flunisolide-treated patients received very good or good ratings, whereas only 29% of placebo-treated patients received these ratings (P = .005). No patient developed thrush, evidence of adrenal suppression, or other severe adverse reaction. Flunisolide aerosol was shown to be effective and safe in controlling asthma in children who were candidates for oral steroid therapy.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Meltzer EO,Kemp JP,Orgel HA,Izu AE

subject

Has Abstract

pub_date

1982-03-01 00:00:00

pages

340-5

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

69

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::Umbilical artery catheters have been associated with thrombotic complications, such as partial or complete occlusion in the aorta, the renal arteries, and other blood vessels. There have been few reports of the long-term consequences of either symptomatic or asymptomatic thrombi. We report a patient, now 22 years of a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.e36

    authors: Adelman RD,Morrell RE

    更新日期:2000-09-01 00:00:00

  • Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction.

    abstract:OBJECTIVE:We evaluated the usefulness of the polymerase chain reaction (PCR) using the insertion sequence IS6110 as the target for DNA to detect Mycobacterium tuberculosis in clinical specimens from children. STUDY DESIGN:This was a prospective, controlled, blinded study comparing PCR on clinical specimens, mycobacter...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Smith KC,Starke JR,Eisenach K,Ong LT,Denby M

    更新日期:1996-02-01 00:00:00

  • Asthma as a barrier to children's physical activity: implications for body mass index and mental health.

    abstract:OBJECTIVES:The purpose of this work was to identify barriers to physical activity in children with asthma and to compare their customary activity levels, BMI and emotional well-being with that of children with other medical conditions. It was hypothesized that children with asthma would have higher BMI and lower levels...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1846

    authors: Glazebrook C,McPherson AC,Macdonald IA,Swift JA,Ramsay C,Newbould R,Smyth A

    更新日期:2006-12-01 00:00:00

  • The effect of recombinant human growth hormone in children with X-linked hypophosphatemia.

    abstract:BACKGROUND:X-linked hypophosphatemia (XLH) is characterized clinically by rickets and growth retardation. Conventional treatment of XLH with oral phosphate and vitamin D fails to normalize linear growth. Objective. To determine the benefit and the potential side effects of recombinant human growth hormone (rhGH) therap...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.100.5.879

    authors: Seikaly MG,Brown R,Baum M

    更新日期:1997-11-01 00:00:00

  • Bedside diagnosis of influenzavirus infections in hospitalized children.

    abstract:OBJECTIVE:For preventing nosocomial influenza infections and to facilitate prompt antiviral therapy, an accessible, rapid diagnostic method for influenzavirus is needed. We evaluated the performance of a lateral-flow immunoassay (QuickVue Influenza Test) completed at the bedside of hospitalized children during the infl...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.1.83

    authors: Poehling KA,Griffin MR,Dittus RS,Tang YW,Holland K,Li H,Edwards KM

    更新日期:2002-07-01 00:00:00

  • Montelukast, compared with fluticasone, for control of asthma among 6- to 14-year-old patients with mild asthma: the MOSAIC study.

    abstract:BACKGROUND:Guidelines recommend daily controller therapy for mild persistent asthma. Montelukast has demonstrated consistent benefit in controlling symptoms of asthma and may be an alternative, orally administered, nonsteroidal agent for treating mild asthma. METHODS:The Montelukast Study of Asthma in Children (MOSAIC...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2004-1172

    authors: Garcia Garcia ML,Wahn U,Gilles L,Swern A,Tozzi CA,Polos P

    更新日期:2005-08-01 00:00:00

  • Serum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy.

    abstract:OBJECTIVE:To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN:We measured concentrations of leuprolide, LH, and follicle-stimulating...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.2.e30

    authors: Bhatia S,Neely EK,Wilson DM

    更新日期:2002-02-01 00:00:00

  • Hypothalamic-pituitary-adrenal axis suppression in asthmatic school children.

    abstract:BACKGROUND AND OBJECTIVE:Hypothalamic-pituitary-adrenal axis suppression (HPAS) when treating children with corticosteroids is thought to be rare. Our objective was to determine the prevalence of and predictive factors for various degrees of HPAS. METHODS:Clinical features of HPAS, doses, adherence, asthma score, and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1147

    authors: Zöllner EW,Lombard CJ,Galal U,Hough FS,Irusen EM,Weinberg E

    更新日期:2012-12-01 00:00:00

  • Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid.

    abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2784

    authors: Robbins JM,Tilford JM,Bird TM,Cleves MA,Reading JA,Hobbs CA

    更新日期:2006-09-01 00:00:00

  • Sexual history documentation in adolescent emergency department patients.

    abstract:OBJECTIVES:To determine the frequency of physician-documented sexual histories in female adolescents who presented to an emergency department (ED) with symptoms suggestive of a sexually transmitted infection (STI). Our secondary objectives were to determine if physician-documented sexual history is associated with incr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1775

    authors: Goyal M,McCutcheon M,Hayes K,Mollen C

    更新日期:2011-07-01 00:00:00

  • Risk factors for traumatic infant death in Oregon, 1973 to 1982.

    abstract::A retrospective study of risk factors for traumatic infant deaths in Oregon occurring from 1973 through 1982 was performed using vital records and medical examiner records. A total of 146 such deaths occurred during this period. Relative risks were calculated for various risk factors in the study group compared with a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Emerick SJ,Foster LR,Campbell DT

    更新日期:1986-04-01 00:00:00

  • Electrocardiograph monitor artifacts in a neonatal intensive care unit.

    abstract::A wide variety of artifacts may be found when monitoring the ECG in a neonatal intensive care unit. Many of the artifacts resemble arrhythmias, and unless they are recognized as artifacts they may lead to serious errors of diagnosis and therapy. Many of the artifacts are caused by patient movement such as seizures, tr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stanger P,Lister G,Silverman NH,Hoffman JI

    更新日期:1977-11-01 00:00:00

  • Role of pediatric health care professionals in the provision of parenting advice: a qualitative study with mothers from 4 minority ethnocultural groups.

    abstract:OBJECTIVE:This study's aim was to elicit the perspectives of minority parents on their expectations of pediatric health care providers as a source of advice on "raising their child" and whether they would seek advice from these providers. A secondary aim was to demonstrate the value of qualitative methods for assessing...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2604

    authors: Dumont-Mathieu TM,Bernstein BA,Dworkin PH,Pachter LM

    更新日期:2006-09-01 00:00:00

  • Ultrasonography: an aid in the diagnosis of masses in pediatric patients.

    abstract::Ultrasound was used to evaluate 100 pediatric patients suspected of having a mass. This technique was found to be useful in several ways: (1) differentiation of cystic, solid, and complex masses, which is not usually possible with routine roentgenographic evaluation; (2) delineation of free fluid collections from thos...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Goldberg BB,Pollack HM,Capitanio MA,Kirkpatrick JA

    更新日期:1975-09-01 00:00:00

  • Parental angst making and revisiting decisions about treatment of attention-deficit/hyperactivity disorder.

    abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioral conditions of childhood and adolescence. Despite availability of effective treatment options, initiation of treatment is variable and persistence with therapeutic regimens is poor. OBJECTIVE:We sought to better underst...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2569

    authors: Brinkman WB,Sherman SN,Zmitrovich AR,Visscher MO,Crosby LE,Phelan KJ,Donovan EF

    更新日期:2009-08-01 00:00:00

  • A case of protein-losing enteropathy caused by intestinal lymphangiectasia in a preterm infant.

    abstract::Intestinal lymphangiectasia is characterized by obstruction of lymph drainage from the small intestine and lacteal dilation that distorts the villus architecture. Lymphatic vessel obstruction and elevated intestinal lymphatic pressure in turn cause lymphatic leakage into the intestinal lumen, thus resulting in malabso...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.2.416

    authors: Salvia G,Cascioli CF,Ciccimarra F,Terrin G,Cucchiara S

    更新日期:2001-02-01 00:00:00

  • Carbamate poisoning: the 'other' insecticide.

    abstract::A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) were also adm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Garber M

    更新日期:1987-05-01 00:00:00

  • Unrecognized human immunodeficiency virus type 1 infection in a cohort of transfused neonates: a retrospective investigation.

    abstract:OBJECTIVE:To retrospectively identify unrecognized human immunodeficiency virus type 1 (HIV-1) infection among a cohort of children transfused as neonates before donated blood was routinely screened for HIV-1 antibody. METHODS:Records at a large, private, metropolitan hospital were reviewed to identify children who we...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lieb LE,Mundy TM,Goldfinger D,Pepkowitz SH,Brunell PA,Caldwell MB,Ward JW

    更新日期:1995-05-01 00:00:00

  • Health Care Use and Health Behaviors Among Young Adults With History of Parental Incarceration.

    abstract:OBJECTIVES:To determine if longitudinal associations exist between parental incarceration (PI) and health care use or health behaviors among a national sample of young adults. METHODS:We used the National Longitudinal Survey of Adolescent to Adult Health to examine associations between history of mother incarceration ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-4314

    authors: Heard-Garris N,Winkelman TNA,Choi H,Miller AK,Kan K,Shlafer R,Davis MM

    更新日期:2018-09-01 00:00:00

  • Using mass media to reduce adolescent involvement in drug trafficking.

    abstract:OBJECTIVE:Drug trafficking among adolescents is a newly recognized high-risk behavior that seems to be involving large numbers of youths. Strategies to prevent and/or alter this behavior must be developed and evaluated. In view of the high exposure of adolescents to the mass media, interventionists seeking to reduce ad...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Romer D

    更新日期:1994-06-01 00:00:00

  • It is time! Accelerating the use of child health information systems to improve child health.

    abstract::Articles in this issue show clearly the enormous impact that the use of health information technology can have on the quality of health care for children. However, they also point out the challenges that need to be overcome to realize fully the potential of health information technology to improve the quality and effi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1755B

    authors: Fairbrother G,Simpson LA

    更新日期:2009-01-01 00:00:00

  • Intima-media thickness and flow-mediated dilatation in the Helsinki study of very low birth weight adults.

    abstract:BACKGROUND:Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance. OBJECTIVE:We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and th...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-2199

    authors: Hovi P,Turanlahti M,Strang-Karlsson S,Wehkalampi K,Järvenpää AL,Eriksson JG,Kajantie E,Andersson S

    更新日期:2011-02-01 00:00:00

  • Renal failure as a complication of acute antihypertensive therapy.

    abstract::Adult patients with long-standing hypertension have been reported to experience an impairment in renal function when treatment with potent vasodilating agents is initiated. To document that this sequence may occur in children as well, we report the case of a 4-year-old boy with renal disease in whom reduction of blood...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Green TP,Nevins TE,Houser MT,Sibley R,Fish AJ,Sinaiko AR

    更新日期:1981-06-01 00:00:00

  • Laparoscopic diagnosis and cure of hyperinsulinism in two cases of focal adenomatous hyperplasia in infancy.

    abstract::Persistent hyperinsulinemic hypoglycemia of infancy or congenital hyperinsulinism of the neonate is a rare condition that may cause severe neurologic damage if the disease is unrecognized or inadequately treated. Current treatment aims to restore normal blood glucose levels by providing a carbohydrate-enriched diet an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2003-1180-L

    authors: De Vroede M,Bax NM,Brusgaard K,Dunne MJ,Groenendaal F

    更新日期:2004-10-01 00:00:00

  • Violaceous discoloration in pneumococcal cellulitis.

    abstract::Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violac...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Thirumoorthi MC,Asmar BI,Dajani AS

    更新日期:1978-10-01 00:00:00

  • Rhabdomyolysis and myoglobinemia in neonates.

    abstract::Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. H...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kasik JW,Leuschen MP,Bolam DL,Nelson RM

    更新日期:1985-08-01 00:00:00

  • Effect of dose formulation on isoniazid absorption in two young children.

    abstract::In an 8-month-old infant with tuberculous meningitis treatment with isoniazid was unsuccessful and was associated with lower than expected plasma concentrations of isoniazid (measured concentration 0.1 microgram/mL). The infant had received isoniazid as a crushed tablet admixed with apple sauce. Oral administration of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Notterman DA,Nardi M,Saslow JG

    更新日期:1986-06-01 00:00:00

  • Risk Stratification of Febrile Infants ≤60 Days Old Without Routine Lumbar Puncture.

    abstract::: media-1vid110.1542/5840460609001PEDS-VA_2018-1879Video Abstract OBJECTIVES: To evaluate the Rochester and modified Philadelphia criteria for the risk stratification of febrile infants with invasive bacterial infection (IBI) who do not appear ill without routine cerebrospinal fluid (CSF) testing. METHODS:We performe...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1879

    authors: Aronson PL,Wang ME,Shapiro ED,Shah SS,DePorre AG,McCulloh RJ,Pruitt CM,Desai S,Nigrovic LE,Marble RD,Leazer RC,Rooholamini SN,Sartori LF,Balamuth F,Woll C,Neuman MI,Febrile Young Infant Research Collaborative.

    更新日期:2018-12-01 00:00:00

  • Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool.

    abstract:OBJECTIVE:Inflicted traumatic brain injury (iTBI) is the leading cause of death from TBI in infants. Misdiagnosis of iTBI is common and results in increased morbidity and mortality. Biomarkers may be able to assist in screening infants who are at high risk for iTBI and whose injury might otherwise be missed. We investi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0711

    authors: Berger RP,Dulani T,Adelson PD,Leventhal JM,Richichi R,Kochanek PM

    更新日期:2006-02-01 00:00:00

  • Isolated sulfite oxidase deficiency: a case report with a novel mutation and review of the literature.

    abstract::Isolated sulfite oxidase deficiency is a rare but devastating neurologic disease that usually presents in early infancy with seizures and alterations in muscle tone. Only 21 cases have been reported in the literature. We report a case of a newborn infant boy with isolated sulfite oxidase deficiency who presented with ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2004-1897

    authors: Tan WH,Eichler FS,Hoda S,Lee MS,Baris H,Hanley CA,Grant PE,Krishnamoorthy KS,Shih VE

    更新日期:2005-09-01 00:00:00