Abstract:
:The efficacy and safety of flunisolide aerosol were studied in 46 steroid-independent children with asthma inadequately controlled by nonsteroid drugs. This was a double-blind, placebo-controlled, parallel study lasting eight weeks. Patients were randomly assigned either flunisolide by inhalation, 0.5 mg twice a day, or placebo. Effectiveness was evaluated daily by symptom scores, by Wright peak flow measurements twice daily, and weekly by spirometry and physical examination. Adrenal function and throat cultures for Candida were evaluated before and after the test-drug treatment period. Flunisolide was administered to 25 patients and 21 received placebo. Most symptom scores were statistically significantly better in flunisolide-treated than in placebo-treated patients; these included severity of wheezing (P = .01), chest tightness (P = .01) and shortness of breath (P = .02), and frequency (P = .001) and severity of asthma attacks (P = .03). In addition, placebo-treated patients used significantly more bronchodilators than flunisolide-treated patients. In the final therapeutic effectiveness evaluation, 72% of flunisolide-treated patients received very good or good ratings, whereas only 29% of placebo-treated patients received these ratings (P = .005). No patient developed thrush, evidence of adrenal suppression, or other severe adverse reaction. Flunisolide aerosol was shown to be effective and safe in controlling asthma in children who were candidates for oral steroid therapy.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Meltzer EO,Kemp JP,Orgel HA,Izu AEsubject
Has Abstractpub_date
1982-03-01 00:00:00pages
340-5issue
3eissn
0031-4005issn
1098-4275journal_volume
69pub_type
临床试验,杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract::Umbilical artery catheters have been associated with thrombotic complications, such as partial or complete occlusion in the aorta, the renal arteries, and other blood vessels. There have been few reports of the long-term consequences of either symptomatic or asymptomatic thrombi. We report a patient, now 22 years of a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.3.e36
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:We evaluated the usefulness of the polymerase chain reaction (PCR) using the insertion sequence IS6110 as the target for DNA to detect Mycobacterium tuberculosis in clinical specimens from children. STUDY DESIGN:This was a prospective, controlled, blinded study comparing PCR on clinical specimens, mycobacter...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1996-02-01 00:00:00
abstract:OBJECTIVES:The purpose of this work was to identify barriers to physical activity in children with asthma and to compare their customary activity levels, BMI and emotional well-being with that of children with other medical conditions. It was hypothesized that children with asthma would have higher BMI and lower levels...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1846
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:X-linked hypophosphatemia (XLH) is characterized clinically by rickets and growth retardation. Conventional treatment of XLH with oral phosphate and vitamin D fails to normalize linear growth. Objective. To determine the benefit and the potential side effects of recombinant human growth hormone (rhGH) therap...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.100.5.879
更新日期:1997-11-01 00:00:00
abstract:OBJECTIVE:For preventing nosocomial influenza infections and to facilitate prompt antiviral therapy, an accessible, rapid diagnostic method for influenzavirus is needed. We evaluated the performance of a lateral-flow immunoassay (QuickVue Influenza Test) completed at the bedside of hospitalized children during the infl...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.1.83
更新日期:2002-07-01 00:00:00
abstract:BACKGROUND:Guidelines recommend daily controller therapy for mild persistent asthma. Montelukast has demonstrated consistent benefit in controlling symptoms of asthma and may be an alternative, orally administered, nonsteroidal agent for treating mild asthma. METHODS:The Montelukast Study of Asthma in Children (MOSAIC...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2004-1172
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN:We measured concentrations of leuprolide, LH, and follicle-stimulating...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.2.e30
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hypothalamic-pituitary-adrenal axis suppression (HPAS) when treating children with corticosteroids is thought to be rare. Our objective was to determine the prevalence of and predictive factors for various degrees of HPAS. METHODS:Clinical features of HPAS, doses, adherence, asthma score, and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1147
更新日期:2012-12-01 00:00:00
abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2784
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To determine the frequency of physician-documented sexual histories in female adolescents who presented to an emergency department (ED) with symptoms suggestive of a sexually transmitted infection (STI). Our secondary objectives were to determine if physician-documented sexual history is associated with incr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1775
更新日期:2011-07-01 00:00:00
abstract::A retrospective study of risk factors for traumatic infant deaths in Oregon occurring from 1973 through 1982 was performed using vital records and medical examiner records. A total of 146 such deaths occurred during this period. Relative risks were calculated for various risk factors in the study group compared with a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::A wide variety of artifacts may be found when monitoring the ECG in a neonatal intensive care unit. Many of the artifacts resemble arrhythmias, and unless they are recognized as artifacts they may lead to serious errors of diagnosis and therapy. Many of the artifacts are caused by patient movement such as seizures, tr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract:OBJECTIVE:This study's aim was to elicit the perspectives of minority parents on their expectations of pediatric health care providers as a source of advice on "raising their child" and whether they would seek advice from these providers. A secondary aim was to demonstrate the value of qualitative methods for assessing...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2604
更新日期:2006-09-01 00:00:00
abstract::Ultrasound was used to evaluate 100 pediatric patients suspected of having a mass. This technique was found to be useful in several ways: (1) differentiation of cystic, solid, and complex masses, which is not usually possible with routine roentgenographic evaluation; (2) delineation of free fluid collections from thos...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurobehavioral conditions of childhood and adolescence. Despite availability of effective treatment options, initiation of treatment is variable and persistence with therapeutic regimens is poor. OBJECTIVE:We sought to better underst...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2569
更新日期:2009-08-01 00:00:00
abstract::Intestinal lymphangiectasia is characterized by obstruction of lymph drainage from the small intestine and lacteal dilation that distorts the villus architecture. Lymphatic vessel obstruction and elevated intestinal lymphatic pressure in turn cause lymphatic leakage into the intestinal lumen, thus resulting in malabso...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.2.416
更新日期:2001-02-01 00:00:00
abstract::A 16-month-old child who ingested rat poison, according to her parents, was noted to have signs of cholinergic poisoning. In the emergency department, the child was intubated and given atropine via the endotracheal tube until venous access was established. Phytonadione (vitamin K) and pralidoxime (2-PAM) were also adm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:To retrospectively identify unrecognized human immunodeficiency virus type 1 (HIV-1) infection among a cohort of children transfused as neonates before donated blood was routinely screened for HIV-1 antibody. METHODS:Records at a large, private, metropolitan hospital were reviewed to identify children who we...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-05-01 00:00:00
abstract:OBJECTIVES:To determine if longitudinal associations exist between parental incarceration (PI) and health care use or health behaviors among a national sample of young adults. METHODS:We used the National Longitudinal Survey of Adolescent to Adult Health to examine associations between history of mother incarceration ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-4314
更新日期:2018-09-01 00:00:00
abstract:OBJECTIVE:Drug trafficking among adolescents is a newly recognized high-risk behavior that seems to be involving large numbers of youths. Strategies to prevent and/or alter this behavior must be developed and evaluated. In view of the high exposure of adolescents to the mass media, interventionists seeking to reduce ad...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1994-06-01 00:00:00
abstract::Articles in this issue show clearly the enormous impact that the use of health information technology can have on the quality of health care for children. However, they also point out the challenges that need to be overcome to realize fully the potential of health information technology to improve the quality and effi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1755B
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance. OBJECTIVE:We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and th...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2010-2199
更新日期:2011-02-01 00:00:00
abstract::Adult patients with long-standing hypertension have been reported to experience an impairment in renal function when treatment with potent vasodilating agents is initiated. To document that this sequence may occur in children as well, we report the case of a 4-year-old boy with renal disease in whom reduction of blood...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-06-01 00:00:00
abstract::Persistent hyperinsulinemic hypoglycemia of infancy or congenital hyperinsulinism of the neonate is a rare condition that may cause severe neurologic damage if the disease is unrecognized or inadequately treated. Current treatment aims to restore normal blood glucose levels by providing a carbohydrate-enriched diet an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2003-1180-L
更新日期:2004-10-01 00:00:00
abstract::Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violac...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1978-10-01 00:00:00
abstract::Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. H...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-08-01 00:00:00
abstract::In an 8-month-old infant with tuberculous meningitis treatment with isoniazid was unsuccessful and was associated with lower than expected plasma concentrations of isoniazid (measured concentration 0.1 microgram/mL). The infant had received isoniazid as a crushed tablet admixed with apple sauce. Oral administration of...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-06-01 00:00:00
abstract::: media-1vid110.1542/5840460609001PEDS-VA_2018-1879Video Abstract OBJECTIVES: To evaluate the Rochester and modified Philadelphia criteria for the risk stratification of febrile infants with invasive bacterial infection (IBI) who do not appear ill without routine cerebrospinal fluid (CSF) testing. METHODS:We performe...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2018-1879
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:Inflicted traumatic brain injury (iTBI) is the leading cause of death from TBI in infants. Misdiagnosis of iTBI is common and results in increased morbidity and mortality. Biomarkers may be able to assist in screening infants who are at high risk for iTBI and whose injury might otherwise be missed. We investi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0711
更新日期:2006-02-01 00:00:00
abstract::Isolated sulfite oxidase deficiency is a rare but devastating neurologic disease that usually presents in early infancy with seizures and alterations in muscle tone. Only 21 cases have been reported in the literature. We report a case of a newborn infant boy with isolated sulfite oxidase deficiency who presented with ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2004-1897
更新日期:2005-09-01 00:00:00