Abstract:
OBJECTIVE:The objectives of this study were to examine growth in children on classical and medium-chain triglyceride ketogenic diets and to investigate any association between growth and calorie or protein intake. METHODS:Weight, height, and BMI z scores were recorded for children who were initiated on 1 of 2 ketogenic diets at baseline and after 3, 6, and 12 months, if continued. Mean calorie and protein intakes during treatment were calculated for children who completed 12 months on the diet. Changes in growth were compared between the 2 diets, and the association between growth and dietary intake was examined. RESULTS:Seventy-five children provided growth data. Weight z scores decreased significantly between baseline and 3, 6, and 12 months; height z scores showed no change at 3 months but decreased significantly by 6 and 12 months. This was more significant in the younger and ambulatory children. Subdivision according to diet type showed weight z scores to decrease significantly in the medium-chain triglyceride group only at 3 and 6 months and in both groups at 12 months. Height z scores decreased significantly in both groups by 6 and 12 months. Forty children completed 12 months of treatment; in this group, the slopes of best-fit regression lines of serial z-score measures were used to represent growth trend. There were no significant differences in mean slope between classical and medium-chain triglyceride diet groups for weight, height, or BMI. There was no significant difference in mean calorie intake during the 12 months between the 2 diets, but the medium-chain triglyceride group had significantly higher protein intake. There was no significant correlation between calorie or protein intakes and the slope of the best-fit line for weight, height, or BMI. CONCLUSIONS:Both weight and height z scores decreased during diet treatment. By 12 months, there was no difference in outcome between classical and medium-chain triglyceride protocols despite the increased protein in the latter diet.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Neal EG,Chaffe HM,Edwards N,Lawson MS,Schwartz RH,Cross JHdoi
10.1542/peds.2007-2410subject
Has Abstractpub_date
2008-08-01 00:00:00pages
e334-40issue
2eissn
0031-4005issn
1098-4275pii
122/2/e334journal_volume
122pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Published data show that plasma creatinine falls steadily during the first 28 days of life and that creatinine levels in the neonatal period are higher in more premature infants. However, the best reference data commence on day 2 of life. The objective of this study was to document how plasma creatinine chang...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.6.e76
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:A substudy of the Management of Myelomeningocele Study evaluating urological outcomes was conducted. METHODS:Pregnant women diagnosed with fetal myelomeningocele were randomly assigned to either prenatal or standard postnatal surgical repair. The substudy included patients randomly assigned after April 18, ...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2015-2114
更新日期:2015-10-01 00:00:00
abstract::An instructive case of isolated congenital folate malabsorption provides insight into the understanding of this rare disease. Folate loading tests with both timed serum and cerebrospinal fluid folate determinations suggest that both of the two mechanisms involved in gastrointestinal folate absorption are defective in ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.5.1133
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:To determine the population impact of pneumococcal conjugate vaccine (PCV) on pneumococcal-related diseases, including pneumonia and otitis media. METHODS:Using administrative data from Tennessee Medicaid and 3 commercial insurance plans in upstate New York, we measured annual rates of medical visits for pne...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2003-0592-F
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate if oropharyngeal swab polymerase chain reaction (PCR) could predict osteoarticular infection (OAI) due to Kingella kingae in young children. METHODS:One hundred twenty-three consecutive children aged 6 to 48 months presenting with atraumatic osteoarticular complai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0810
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To determine the short-term efficacy of meso-2,3-dimercaptosuccinic acid (DMSA) in mild to moderately lead poisoned children. METHODS:Medical records of all pediatric patients receiving 19 days of DMSA between June 1991 and May 1993 were reviewed retrospectively. Patients were included if their pretreatment ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Foreign body ingestion is a potentially serious clinical problem in children. We report a case of an 8-month-old infant who developed complete bowel obstruction requiring laparotomy due to ingestion of a superabsorbent polymer ball with advertised growth up to 400 times its original size. Most ingested foreign bodies ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3685
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:The goal of this study was to develop an algorithm based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), codes for classifying children with chronic disease (CD) according to level of medical complexity and to assess the algorithm's sensitivity and specificity. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-3875
更新日期:2014-06-01 00:00:00
abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0291
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:The objective for this study was to characterize the impact and the safety of transporting neonates with known or suspected cardiac abnormalities. METHODS:We reviewed retrospectively the charts and computerized records of 192 admissions to a cardiac ICU in 2002. Patients were included when they were < 28 day...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0719
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To determine whether infants who are fed initially and advanced at 30 mL/kg per day (intervention) take fewer days to get to full feedings than those who are fed initially and advanced at 20 mL/kg per day (control), without increasing their incidence of feeding complications and necrotizing enterocolitis (NE...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.2004-1232
更新日期:2004-12-01 00:00:00
abstract::To distinguish spermatic cord torsion from other intrascrotal pathology, scrotal ultrasound and radionuclide scanning have been highly recommended on the basis of both clinical and experimental studies. We review the data from six patients in whom ultrasound or nuclear medicine examination was misleading. We emphasize...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVES:To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs). METHODS:A survey was administered to paren...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2011-3075
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Recombinant interferon alpha (IFN-alpha) treatment is useful in 40% of children with chronic hepatitis B. However, nonresponder children continue to have viral replication and a progressive disease. OBJECTIVE:To administer natural IFN-beta to hepatitis B virus chronic carrier children who had not responded ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.99.2.222
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND:Research shows that the development of cardiometabolic disease can begin early in life with risk factors accumulating over time, but less is known about protective pathways to positive health. In this study, we use prospective data to test whether childhood assets predict a greater likelihood of being in opt...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-2004
更新日期:2019-03-01 00:00:00
abstract::Developmental screening tests are in widespread use, but few reliable and valid tests are available. The most frequently used screening instrument for detecting young children who are at risk for developmental delays is the Denver Developmental Screening Test (DDST). Although the DDST has excellent test specificity, o...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1989-04-01 00:00:00
abstract:UNLABELLED:Emergency contraception (EC) is the use of a method of contraception after unprotected intercourse to prevent unintended pregnancy. Although first described over 20 years ago, physician awareness of EC has been limited and many feel uncomfortable prescribing it. OBJECTIVE:To assess the knowledge, attitudes,...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.2.287
更新日期:2001-02-01 00:00:00
abstract::The efficacy, adverse reactions, and long-term effects of intestinal lavage treatment with a balanced electrolyte solution (Golytely) was evaluated in patients with cystic fibrosis and distal intestinal obstruction syndrome. Twenty-two patients with cystic fibrosis (mean age 21.8 years, range 14 to 34 years, 15 boys o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-05-01 00:00:00
abstract::Two noninvasive methods of localizing the site of urinary tract infection, urinary lactic dehydrogenase (LDH) isoenzymes and antibody coating of bacteria in the urinary sediment, have been prospectively compared with the bladder washout technique in a series of children with urinary tract infection. Fifteen children h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-11-01 00:00:00
abstract::Sarcosinemia has been detected by routine screening of urine for metabolic and transport disorders in Massachusetts. Three infants who had sarcosinemia were detected through the neonatal urine specimen, an observed incidence of 1:350,000. A fourth child had sarcosinemia detected through family screening after his brot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Varicella vaccine was licensed in the United States in 1995 for individuals ≥12 months of age. A second dose was recommended in the United States in June 2006. Varicella incidence and vaccine effectiveness were assessed in a 14-year prospective study conducted at Kaiser Permanente Northern California. METHO...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2012-3303
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to d...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.100.1.60
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Compared with other parents, mothers of children with autism spectrum disorder or other neurodevelopmental disabilities experience more stress, illness, and psychiatric problems. Although the cumulative stress and disease burden of these mothers is exceptionally high, and associated with poorer outcomes in c...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-3164
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To examine the impact of admission-day illness severity on nosocomial bacteremia risk after consideration of traditional risk determinants such as birth weight and length of stay. METHODS:The hospital courses for 302 consecutive very low birth weight (less than 1500 g) infants admitted to two neonatal intens...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVE:Iron deficiency anemia is known to impair cognitive and psychomotor development. The zinc protoporphyrin/heme (ZPP/H) ratio is a simple, accurate, and sensitive laboratory screening test that detects early iron depletion before the onset of anemia. The objective of this work was to evaluate this test in a pri...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.3.e37
更新日期:1999-09-01 00:00:00
abstract::An 11-year-old boy had clinical signs of an acute inferior wall myocardial infarction. On echocardiography, a left atrial myxoma was demonstrated. Coronary artery embolization from myxoma was confirmed by selective coronary arteriography. The tumor was removed 12 days after acute coronary embolization. The clinical va...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:Lithium is a benchmark treatment for bipolar disorder in adults. Definitive studies of lithium in pediatric bipolar I disorder (BP-I) are lacking. METHODS:This multicenter, randomized, double-blind, placebo-controlled study of pediatric participants (ages 7-17 years) with BP-I/manic or mixed episodes compar...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2015-0743
更新日期:2015-11-01 00:00:00
abstract::Postnatal ductal closure is stimulated by rising oxygen tension and withdrawal of vasodilatory mediators (prostaglandins, nitric oxide, adenosine) and by vasoconstrictors (endothelin-1, catecholamines, contractile prostanoids), ion channels, calcium flux, platelets, morphologic maturity, and a favorable genetic predis...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2020-1209
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVES:We had the rare opportunity to conduct a cluster-randomized controlled trial to observe the long-term (16-year) effects of a well-designed hearing conservation intervention for rural high school students. This trial assessed whether the intervention resulted in (1) reduced prevalence of noise-induced hearing...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2011-0770
更新日期:2011-11-01 00:00:00