Genetic variation in PNPLA3 but not APOC3 influences liver fat in non-alcoholic fatty liver disease.

abstract：BACKGROUND AND AIM:Chronic hepatitis C virus (HCV) infection is the leading cause of liver diseases including cirrhosis and hepatocellular carcinoma. In China, it is a major national health problem that demands nationwide coordinated emphasis on prevention and treatment. To inform these initiatives, a nationwide survey...

journal_title：Journal of gastroenterology and hepatology

authors： Wei L,Li J,Yang X,Wang G,Feng B,Hou J,Duan Z,Jia J,Ren H,Niu J,Chen X,Wang FS,Shang J,Bo Q,Li R,Liu Y,Zhuang H

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND AND AIM:In the condition of high prevalence of non-alcoholic fatty liver disease (NAFLD), a new diagnostic algorithm to efficiently identify NAFLD patients with significant fibrosis is urgently required. We evaluated the predictive ability of the fibrosis-4 index (FIB-4 index) for significant liver fibrosis ...

journal_title：Journal of gastroenterology and hepatology

authors： Tomeno W,Imajo K,Kuwada Y,Ogawa Y,Kikuchi M,Honda Y,Kato T,Kessoku T,Kirikoshi H,Yoneda M,Kitahora T,Saito S,Ozawa Y,Nakajima A

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:We designed an animal model in order to clarify whether Helicobacter pylori infection causes the gastric mucosal lesion frequently seen in cirrhotic patients. METHODS:Ammonia (NH3) solution was given to rats with carbon tetrachloride-induced cirrhosis. The gastric mucosal hexosamine (Hx) content and histopa...

journal_title：Journal of gastroenterology and hepatology

authors： Sugimoto M,Machida Y,Ito K

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND AND AIM:There is scanty data on the occurrence of celiac disease in patients with type 1 diabetes mellitus in South Asia. Our aim was to study the prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in a tertiary care referral centre in north India. METHODS:Consecutiv...

journal_title：Journal of gastroenterology and hepatology

authors： Bhadada SK,Kochhar R,Bhansali A,Dutta U,Kumar PR,Poornachandra KS,Vaiphei K,Nain CK,Singh K

更新日期：2011-02-01 00:00:00

abstract：:Differentiation between gastric adenomas and type IIa early gastric cancer by macroscopic and histologic examinations is often difficult. This study has shown that there are differences in the distribution of S-phase cells in these two types of tumour, and these differences can be exploited to differentiate between th...

journal_title：Journal of gastroenterology and hepatology

authors： Miwa H,Wada R,Abe H,Ohkura R,Yang SW,Watanabe H,Ogihara T,Hamada T,Sato N

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND AND AIM:To present the experience in management of inflammatory liver pseudotumors from a specialist surgical unit and to review the medical literature on this rare manifestation. METHODS:Between 1995 and 2008, four patients were identified with this type of tumor from a total of 108 resected benign liver l...

journal_title：Journal of gastroenterology and hepatology

authors： Milias K,Madhavan KK,Bellamy C,Garden OJ,Parks RW

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the change...

journal_title：Journal of gastroenterology and hepatology

authors： Uehara H,Akahoshi T,Tomikawa M,Kinjo N,Hashimoto N,Nagao Y,Kamori M,Maehara Y

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND AND AIM:The attenuated antisecretory activity observed during continuous administration of ranitidine has been described as tolerance. However, it remains unclear whether a similar phenomenon occurs with other histamine H2 receptor antagonists (H2RA). We investigated whether tolerance to famotidine, a strong...

journal_title：Journal of gastroenterology and hepatology

authors： Komazawa Y,Adachi K,Mihara T,Ono M,Kawamura A,Fujishiro H,Kinoshita Y

更新日期：2003-06-01 00:00:00

abstract：:Significant bile leak is an uncommon but serious complication of biliary tract surgery. Of twenty-five patients presenting with postoperative bile leak, 11 had complete tie-off of common bile duct and required surgery, while the remaining 14 had injury without complete obstruction and could be managed by endoscopic me...

journal_title：Journal of gastroenterology and hepatology

authors： Saraswat VA,Choudhuri G,Sharma BC,Agarwal DK,Gupta R,Baijal SS,Sikora SS,Saxena R,Kapoor VK

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of the present study was to compare the therapeutic efficacy of three different regimens in childhood chronic hepatitis B (CHB) infection. METHODS:A total of 182 children with CHB infection were prospectively allocated to three random groups. Sixty-two patients in the first group received hi...

journal_title：Journal of gastroenterology and hepatology

authors： Dikici B,Ozgenc F,Kalayci AG,Targan S,Ozkan T,Selimoglu A,Doganci T,Kansu A,Tosun S,Arslan N,Kasirga E,Bosnak M,Haspolat K,Buyukgebiz B,Aydogdu S,Girgin N,Yagci RV

更新日期：2004-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Hepatic steatosis has been shown to be associated with lipid peroxidation and hepatic fibrosis in a variety of liver diseases including non-alcoholic fatty liver disease. However, the lobular distribution of lipid peroxidation associated with hepatic steatosis, and the influence of hepatic iron stor...

journal_title：Journal of gastroenterology and hepatology

authors： MacDonald GA,Bridle KR,Ward PJ,Walker NI,Houglum K,George DK,Smith JL,Powell LW,Crawford DH,Ramm GA

更新日期：2001-06-01 00:00:00

abstract：:Barrett's esophagus (BE), a common condition, is the only known precursor to esophageal adenocarcinoma (EAC). There is uncertainty about the best way to manage BE as most people with BE never develop EAC and most patients diagnosed with EAC have no preceding diagnosis of BE. Moreover, there have been recent advances i...

journal_title：Journal of gastroenterology and hepatology

authors： Whiteman DC,Appleyard M,Bahin FF,Bobryshev YV,Bourke MJ,Brown I,Chung A,Clouston A,Dickins E,Emery J,Eslick GD,Gordon LG,Grimpen F,Hebbard G,Holliday L,Hourigan LF,Kendall BJ,Lee EY,Levert-Mignon A,Lord RV,Lord SJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:The relationship between visceral adiposity and the incidence of functional dyspepsia (FD) has not yet been studied. The purpose of the present study is to evaluate the association between visceral adiposity and the risk of FD. METHODS:This is a case-control study that compares the abdominal adipose tissue ...

journal_title：Journal of gastroenterology and hepatology

authors： Jung JG,Yang JN,Lee CG,Choi SH,Kwack WG,Lee JH,Kang HW

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:There is a wide variation in the prevalence of peptic ulcer in India both before and since the use of endoscopy. We studied the prevalence of peptic ulcer disease in a community in northern India and its relationship with Helicobacter pylori infection. METHODS:A house-to-house survey of residents aged 15 ye...

journal_title：Journal of gastroenterology and hepatology

authors： Singh V,Trikha B,Nain CK,Singh K,Vaiphei K

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND:The efficiency of Helicobacter pylori eradication varies geographically, as do many parameters that might affect therapeutic efficiency. The aims of this study were to investigate the relationship between different genotypes of H. pylori and bacterium-related histopathological lesions in patients with duoden...

journal_title：Journal of gastroenterology and hepatology

authors： Zhao JJ,Wang JB,Yang L,Li Y

更新日期：2007-12-01 00:00:00

abstract：AIMS:The aim of this study was to determine the cumulative rate of flare-up of serum alanine aminotransferase (ALT) level during a 10-year follow-up period, and characterize the clinical, virologic features in 120 hepatitis C virus (HCV) RNA-positive asymptomatic carriers with persistently normal ALT levels for 6 month...

journal_title：Journal of gastroenterology and hepatology

authors： Tsuji K,Yamasaki K,Yamanishi M,Kawakami M,Shirahama S

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND AND AIM:Liver transplantation remains the best option for treating type-1 hepatorenal syndrome (HRS1). The aim of this retrospective study was to determine whether the molecular adsorbent recirculation system (MARS) can improve renal function in HRS1 patients. METHODS:Thirty-two patients with chronic liver ...

journal_title：Journal of gastroenterology and hepatology

authors： Lavayssière L,Kallab S,Cardeau-Desangles I,Nogier MB,Cointault O,Barange K,Muscari F,Rostaing L,Kamar N

更新日期：2013-06-01 00:00:00

abstract：:Two hundred and fifty-three cases of acute viral hepatitis admitted to Ibn Al-Khateeb Infectious Disease Hospital, Baghdad, were studied prospectively regarding the viral aetiological agent. The most common cause was infection with one of the non-A, non-B viruses (51%). The second most common cause was infection with ...

journal_title：Journal of gastroenterology and hepatology

authors： Rassam SW,Goudeau AM,Dubois F,al-Khoury BN,al-Deen JA,Sadik AM

更新日期：1989-03-01 00:00:00

abstract：BACKGROUND AND AIMS:The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India. METHODS:In 20 patients and 120 healthy controls, polymerase chain reaction ampli...

journal_title：Journal of gastroenterology and hepatology

authors： Shankarkumar U,Amarapurkar DN,Kankonkar S

更新日期：2005-02-01 00:00:00

abstract：BACKGROUND AND AIM:Liver fibrosis is an established determinant of prognosis and therapy in chronic hepatitis B (CHB). The role of fibroscan in assessing fibrosis in CHB remains unclear. Present study was designed to correlate fibroscan with liver biopsy and determine whether fibroscan can avoid liver biopsy in patient...

journal_title：Journal of gastroenterology and hepatology

authors： Goyal R,Mallick SR,Mahanta M,Kedia S,Shalimar,Dhingra R,Sharma H,Das P,Datta Gupta S,Panda S,Acharya SK

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND AND AIM:Results obtained from different hepatitis E virus (HEV) tests are usually inconsistent. The detection of serum HEV antigen (Ag) has been suggested to be more sensitive for the diagnosis of genotypes 1 and 3 HEV. METHODS:We compared the diagnostic accuracies of serum HEV Ag and HEV RNA by using 202 s...

journal_title：Journal of gastroenterology and hepatology

authors： Zhang H,Rao H,Wang Y,Wang J,Kong X,Ji Y,Zhu L,Liu Y,Fang J,Yang M,Luo B,Wang Z,Shi Y,Wang Y,Wang H,Zhao J,Wei L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:To evaluate the accuracy of two rapid whole blood tests (the BM-Test Helicobacter pylori and the QuikPac IV One Step H. pylori Whole Blood Test), and compare this to a conventional quantitative ELISA test (HEL-p TEST II). METHODS:Helicobacter pylori status in dyspeptic patients was assessed by culture, hist...

journal_title：Journal of gastroenterology and hepatology

authors： Chen TS,Chang FY,Lee SD

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND AND AIM:Liver stiffness (LS), measured by transient elastography, has been validated as a non-invasive surrogate for liver fibrosis. METHODS:We investigated the long-term predictive ability of LS for hepatocellular carcinoma (HCC) development and overall survival in 1146 patients with chronic hepatitis C by...

journal_title：Journal of gastroenterology and hepatology

authors： Nakagomi R,Tateishi R,Masuzaki R,Soroida Y,Iwai T,Kondo M,Fujiwara N,Sato M,Minami T,Uchino K,Enooku K,Nakagawa H,Asaoka Y,Kondo Y,Tanaka Y,Otsuka M,Kato N,Moriya K,Ikeda H,Koike K

更新日期：2019-05-01 00:00:00

abstract：:Typhoid fever is often associated with abnormal liver biochemical tests, but severe hepatic involvement with a clinical feature of acute hepatitis is a rare complication. There have been more than 150 cases of salmonella hepatitis reported from both developed and developing countries. The documented incidence varies w...

journal_title：Journal of gastroenterology and hepatology

authors： Pramoolsinsap C,Viranuvatti V

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND AND AIM:The role of hypoxia-inducible factor-1α (HIF-1α) and hypoxia-inducible factor-2α (HIF-2α) has been implicated in the clinical prognosis of hepatocellular carcinoma (HCC), but the results remain controversial. We aim to investigate the association of HIF-1α and HIF-2α overexpression with the prognosis...

journal_title：Journal of gastroenterology and hepatology

authors： Ding ZN,Dong ZR,Chen ZQ,Yang YF,Yan LJ,Li HC,Liu KX,Yao CY,Yan YC,Yang CC,Li T

更新日期：2021-01-04 00:00:00

abstract：BACKGROUND:Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolic enzyme. Recent studies have focused on the immunoregulatory role of IDO in mononuclear cells. The role of IDO in hepatocellular carcinoma (HCC) cell lines and HCC patients was examined. METHODS:The expression of IDO mRNA in peripheral blood mononuc...

journal_title：Journal of gastroenterology and hepatology

authors： Ishio T,Goto S,Tahara K,Tone S,Kawano K,Kitano S

更新日期：2004-03-01 00:00:00

abstract：:There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk fact...

journal_title：Journal of gastroenterology and hepatology

authors： Pandol S,Gukovskaya A,Edderkaoui M,Dawson D,Eibl G,Lugea A

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND AIMS:Cancer invasion and metastasis are critical events for patient prognosis; however, the most important step in the whole process of lymph node (LN) metastasis in gastric cancer remains obscure. In this study, the significance of cancer cell behaviors, such as cell detachment, stromal invasion and lym...

journal_title：Journal of gastroenterology and hepatology

authors： Kamata I,Ishikawa Y,Akishima-Fukasawa Y,Ito K,Akasaka Y,Uzuki M,Fujimoto A,Morita H,Tamai S,Maehara T,Ogata K,Shimokawa R,Igarashi Y,Miki K,Ishii T

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND AND AIM:6-Mercaptopurine (6-MP) and azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations in Japanese children with IBD have not been reported. METHODS:This retrospective review examines 32...

journal_title：Journal of gastroenterology and hepatology

authors： Ohtsuka Y,Arai K,Aoyagi Y,Fujii T,Yamakawa Y,Ohtani K,Ikuse T,Baba Y,Inage E,Kudo T,Suzuki R,Nagata S,Shimizu T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIM:Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein that plays a significant role in tumor development. SPARC has been indicated that promotes tumorigenesis, metastasis, and poor prognosis in prostate cancer and lung cancer. Therefore, we sought to investigate the mol...

journal_title：Journal of gastroenterology and hepatology

authors： Jiang X,Liu F,Wang Y,Gao J

更新日期：2019-10-01 00:00:00