Prediction of improved liver function after balloon-occluded retrograde transvenous obliteration: relation to hepatic vein pressure gradient.

Abstract:

BACKGROUND AND AIMS:Balloon-occluded retrograde transvenous obliteration (B-RTO) is an effective treatment for gastric varices (GVx), as well as hepatic encephalopathy. The aim of this study was to examine the changes of the hepatic vein pressure gradient (HVPG) after B-RTO and determine the relation between the changes of HVPG and liver function. PATIENTS AND METHODS:B-RTO was performed in 30 patients with GVx and hepatic encephalopathy. HVPG was measured in 19 of 30 patients both before and after B-RTO. RESULTS:The B-RTO was successful in all patients. The GVx and hepatic encephalopathy were improved, and no recurrence or bleeding was observed within the follow- up period. The serum albumin and prothrombin activity were significantly improved 6 months after B-RTO in all patients. HVPG was elevated 44% above the baseline after B-RTO. Liver function significantly improved 6 months after B-RTO in patients whose HVPG increased ≥ 20% from baseline. CONCLUSION:An elevated HVPG after B-RTO is one aspect of the effect of liver function, and an HVPG increase of ≥ 20% from baseline is a predictive factor for obtaining an improvement of liver function.

authors

Uehara H,Akahoshi T,Tomikawa M,Kinjo N,Hashimoto N,Nagao Y,Kamori M,Maehara Y

doi

10.1111/j.1440-1746.2011.06835.x

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

137-41

issue

1

eissn

0815-9319

issn

1440-1746

journal_volume

27

pub_type

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