Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations.

abstract：:Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...

journal_title：Angiogenesis

authors： Lin CI,Merley A,Sciuto TE,Li D,Dvorak AM,Melero-Martin JM,Dvorak HF,Jaminet SC

更新日期：2014-10-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：:During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α parti...

journal_title：Angiogenesis

authors： Nauta TD,van den Broek M,Gibbs S,van der Pouw-Kraan TC,Oudejans CB,van Hinsbergh VW,Koolwijk P

更新日期：2017-02-01 00:00:00

abstract：:The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...

journal_title：Angiogenesis

authors： Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

更新日期：2003-01-01 00:00:00

abstract：:Prothrombin, a protein involved in blood coagulation, is a plasma glycoprotein composed of the Gla domain, two adjacent kringle domains, and a serine protease domain. Kringles are triple-disulfide-loop folding domains, which are found in several other blood proteins. In this study, we showed that recombinant human pro...

journal_title：Angiogenesis

authors： Kim TH,Kim E,Yoon D,Kim J,Rhim TY,Kim SS

更新日期：2002-01-01 00:00:00

abstract：INTRODUCTION:Endoglin (ENG) forms a receptor complex with ALK1 in endothelial cells (ECs) to promote BMP9/10 signalling. Loss of function mutations in either ENG or ALK1 genes lead to the inherited vascular disorder hereditary haemorrhagic telangiectasia (HHT), characterised by arteriovenous malformations (AVMs). Howev...

journal_title：Angiogenesis

authors： Singh E,Redgrave RE,Phillips HM,Arthur HM

更新日期：2020-11-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...

journal_title：Angiogenesis

authors： García-Martínez E,Redondo A,Piulats JM,Rodríguez A,Casado A

更新日期：2020-11-01 00:00:00

abstract：:Chemokine (C-C motif) receptor-2 (CCR2) regulates arteriogenesis and angiogenesis, facilitating the MCP-1-dependent recruitment of growth factor-secreting bone marrow-derived cells (BMCs). Here, we tested the hypothesis that the BMC-specific expression of CCR2 is also required for new arteriole formation via capillary...

journal_title：Angiogenesis

authors： Nickerson MM,Burke CW,Meisner JK,Shuptrine CW,Song J,Price RJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Clinical and pathological characteristics are still considered prognostic markers in metastatic non-small-cell lung cancer (NSCLC) patients but they cannot explain all interindividual variability. Tumoral angiogenesis mediated by the vascular endothelial growth factor (VEGF) is critical for the progression...

journal_title：Angiogenesis

authors： Sullivan I,Riera P,Andrés M,Altés A,Majem M,Blanco R,Capdevila L,Barba A,Barnadas A,Salazar J

更新日期：2019-08-01 00:00:00

abstract：:Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into ph...

journal_title：Angiogenesis

authors： Núñez-Gómez E,Pericacho M,Ollauri-Ibáñez C,Bernabéu C,López-Novoa JM

更新日期：2017-02-01 00:00:00

abstract：:The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphati...

journal_title：Angiogenesis

authors： Liao S,von der Weid PY

更新日期：2014-04-01 00:00:00

abstract：:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimula...

journal_title：Angiogenesis

authors： Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG

更新日期：1998-01-01 00:00:00

abstract：:Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Increasing reports demonstrated that non-coding RNAs (ncRNAs) have been crucially involved in the development of CVDs. Piwi-interacting RNAs (piRNAs) are a novel cluster of small non-coding RNAs with strong uracil bias at the 5' end and 2'-O-met...

journal_title：Angiogenesis

authors： Li M,Yang Y,Wang Z,Zong T,Fu X,Aung LHH,Wang K,Wang JX,Yu T

更新日期：2020-10-04 00:00:00

abstract：:Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...

journal_title：Angiogenesis

authors： Costa C,Incio J,Soares R

更新日期：2007-01-01 00:00:00

abstract：:Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macu...

journal_title：Angiogenesis

authors： Adamis AP,Aiello LP,D'Amato RA

更新日期：1999-01-01 00:00:00

abstract：:Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...

journal_title：Angiogenesis

authors： Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

更新日期：2018-05-01 00:00:00

abstract：:During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...

journal_title：Angiogenesis

authors： Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld M

更新日期：2012-06-01 00:00:00

abstract：:Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype d...

journal_title：Angiogenesis

authors： Kaspi E,Guillet B,Piercecchi-Marti MD,Alfaidy N,Bretelle F,Bertaud-Foucault A,Stalin J,Rambeloson L,Lacroix O,Blot-Chabaud M,Dignat-George F,Bardin N

更新日期：2013-04-01 00:00:00

abstract：:Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...

journal_title：Angiogenesis

authors： Trevino JG,Gray MJ,Nawrocki ST,Summy JM,Lesslie DP,Evans DB,Sawyer TK,Shakespeare WC,Watowich SS,Chiao PJ,McConkey DJ,Gallick GE

更新日期：2006-01-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...

journal_title：Angiogenesis

authors： Kalkunte S,Brard L,Granai CO,Swamy N

更新日期：2005-01-01 00:00:00

abstract：:Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid...

journal_title：Angiogenesis

authors： Le Cras TD,Mobberley-Schuman PS,Broering M,Fei L,Trenor CC 3rd,Adams DM

更新日期：2017-02-01 00:00:00

abstract：:Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular pathways preventing subretinal vascularization remain largely unknown. In...

journal_title：Angiogenesis

authors： Niaudet C,Petkova M,Jung B,Lu S,Laviña B,Offermanns S,Brakebusch C,Betsholtz C

更新日期：2019-11-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：:Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...

journal_title：Angiogenesis

authors： Zhu XD,Sun HC,Xu HX,Kong LQ,Chai ZT,Lu L,Zhang JB,Gao DM,Wang WQ,Zhang W,Zhuang PY,Wu WZ,Wang L,Tang ZY

更新日期：2013-10-01 00:00:00

abstract：:The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...

journal_title：Angiogenesis

authors： Liang H,Ge F,Xu Y,Xiao J,Zhou Z,Liu R,Chen C

更新日期：2018-11-01 00:00:00

abstract：:The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some n...

journal_title：Angiogenesis

authors： Zhou H,Binmadi NO,Yang YH,Proia P,Basile JR

更新日期：2012-09-01 00:00:00

abstract：:Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

journal_title：Angiogenesis

authors： Masiero L,Figg WD,Kohn EC

更新日期：1997-01-01 00:00:00

abstract：:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

journal_title：Angiogenesis

authors： Zhang Y,Wang S,Dudley AC

更新日期：2020-02-01 00:00:00

abstract：:Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...

journal_title：Angiogenesis

authors： Groothuis PG,Nap AW,Winterhager E,Grümmer R

更新日期：2005-01-01 00:00:00