Piwi-interacting RNAs (piRNAs) as potential biomarkers and therapeutic targets for cardiovascular diseases.

abstract：:Among the key effects of fluid shear stress on vascular endothelial cells is modulation of gene expression. Promoter sequences termed shear stress response elements (SSREs) mediate the responsiveness of endothelial genes to shear stress. While previous studies showed that shear stress responsiveness is mediated by a s...

journal_title：Angiogenesis

authors： Silberman M,Barac YD,Yahav H,Wolfovitz E,Einav S,Resnick N,Binah O

更新日期：2009-01-01 00:00:00

abstract：:The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...

journal_title：Angiogenesis

authors： Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

更新日期：2008-01-01 00:00:00

abstract：:Vascular anomalies can cause significant morbidity and mortality. Advances in diagnosis will be improved if noninvasive biomarkers can be identified, as obtaining a tissue biopsy can worsen the disease and precipitate complications. The goal of this study was to identify biomarkers for vascular anomaly patients to aid...

journal_title：Angiogenesis

authors： Le Cras TD,Mobberley-Schuman PS,Broering M,Fei L,Trenor CC 3rd,Adams DM

更新日期：2017-02-01 00:00:00

abstract：:Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macu...

journal_title：Angiogenesis

authors： Adamis AP,Aiello LP,D'Amato RA

更新日期：1999-01-01 00:00:00

abstract：:During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α parti...

journal_title：Angiogenesis

authors： Nauta TD,van den Broek M,Gibbs S,van der Pouw-Kraan TC,Oudejans CB,van Hinsbergh VW,Koolwijk P

更新日期：2017-02-01 00:00:00

abstract：INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...

journal_title：Angiogenesis

authors： Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

更新日期：2020-05-01 00:00:00

abstract：INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...

journal_title：Angiogenesis

authors： Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

更新日期：2018-11-01 00:00:00

abstract：:Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...

journal_title：Angiogenesis

authors： Lanza GM,Winter PM,Caruthers SD,Hughes MS,Hu G,Schmieder AH,Wickline SA

更新日期：2010-06-01 00:00:00

abstract：:Chemokine (C-C motif) receptor-2 (CCR2) regulates arteriogenesis and angiogenesis, facilitating the MCP-1-dependent recruitment of growth factor-secreting bone marrow-derived cells (BMCs). Here, we tested the hypothesis that the BMC-specific expression of CCR2 is also required for new arteriole formation via capillary...

journal_title：Angiogenesis

authors： Nickerson MM,Burke CW,Meisner JK,Shuptrine CW,Song J,Price RJ

更新日期：2009-01-01 00:00:00

abstract：:Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...

journal_title：Angiogenesis

authors： Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

更新日期：2013-04-01 00:00:00

abstract：:Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular pathways preventing subretinal vascularization remain largely unknown. In...

journal_title：Angiogenesis

authors： Niaudet C,Petkova M,Jung B,Lu S,Laviña B,Offermanns S,Brakebusch C,Betsholtz C

更新日期：2019-11-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...

journal_title：Angiogenesis

authors： Ehling J,Misiewicz M,von Stillfried S,Möckel D,Bzyl J,Pochon S,Lederle W,Knuechel R,Lammers T,Palmowski M,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...

journal_title：Angiogenesis

authors： Miwa D,Sakaue T,Inoue H,Takemori N,Kurokawa M,Fukuda S,Omi K,Goishi K,Higashiyama S

更新日期：2013-07-01 00:00:00

abstract：:The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....

journal_title：Angiogenesis

authors： Li Q,Michaud M,Canosa S,Kuo A,Madri JA

更新日期：2011-05-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...

journal_title：Angiogenesis

authors： Curatola AM,Xu J,Hendricks-Munoz KD

更新日期：2011-09-01 00:00:00

abstract：:The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...

journal_title：Angiogenesis

authors： Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

更新日期：2003-01-01 00:00:00

abstract：:Immunostaining with endothelial and pericyte markers was used to evaluate the cellular composition of angiogenic sprouts in several types of tumors and in the developing retina. Confocal microscopy revealed that, in addition to conventional endothelial tubes heavily invested by pericytes, all tissues contained small p...

journal_title：Angiogenesis

authors： Ozerdem U,Stallcup WB

更新日期：2003-01-01 00:00:00

abstract：:Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...

journal_title：Angiogenesis

authors： Zhu XD,Sun HC,Xu HX,Kong LQ,Chai ZT,Lu L,Zhang JB,Gao DM,Wang WQ,Zhang W,Zhuang PY,Wu WZ,Wang L,Tang ZY

更新日期：2013-10-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...

journal_title：Angiogenesis

authors： García-Martínez E,Redondo A,Piulats JM,Rodríguez A,Casado A

更新日期：2020-11-01 00:00:00

abstract：:The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...

journal_title：Angiogenesis

authors： Persigehl T,Ring J,Bremer C,Heindel W,Holtmeier R,Stypmann J,Claesener M,Hermann S,Schäfers M,Zerbst C,Schliemann C,Mesters RM,Berdel WE,Schwöppe C

更新日期：2014-01-01 00:00:00

abstract：:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimula...

journal_title：Angiogenesis

authors： Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG

更新日期：1998-01-01 00:00:00

abstract：:Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...

journal_title：Angiogenesis

authors： Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

更新日期：2017-05-01 00:00:00

abstract：:The establishment of a vascular network within tumours is a key step in the progression towards an aggressive, metastatic state, with poor prognosis. We have developed a novel in vitro model to specifically capture the interaction between endothelial cells and solid tumours. Micro-vascularised in vitro tumour construc...

journal_title：Angiogenesis

authors： Timmins NE,Dietmair S,Nielsen LK

更新日期：2004-01-01 00:00:00

abstract：:Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...

journal_title：Angiogenesis

authors： Trevino JG,Gray MJ,Nawrocki ST,Summy JM,Lesslie DP,Evans DB,Sawyer TK,Shakespeare WC,Watowich SS,Chiao PJ,McConkey DJ,Gallick GE

更新日期：2006-01-01 00:00:00

abstract：:Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...

journal_title：Angiogenesis

authors： Afonyushkin T,Oskolkova OV,Bochkov VN

更新日期：2018-05-01 00:00:00

abstract：:Technology has caught up with retinal diseases of neovasculature. Work with anti-cancer, anti-angiogenic agents has fueled the way for ocular therapeutics. The market size for age-related macular degeneration and diabetic retinopathy is huge. Fifteen million people in the United States alone have age-related macular d...

journal_title：Angiogenesis

authors： Sherris D

更新日期：2007-01-01 00:00:00

abstract：:Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...

journal_title：Angiogenesis

authors： Gianni-Barrera R,Trani M,Fontanellaz C,Heberer M,Djonov V,Hlushchuk R,Banfi A

更新日期：2013-01-01 00:00:00

abstract：:Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...

journal_title：Angiogenesis

authors： Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

更新日期：1999-01-01 00:00:00

abstract：:Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...

journal_title：Angiogenesis

authors： van Wijk XM,van Kuppevelt TH

更新日期：2014-07-01 00:00:00

abstract：:Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we ...

journal_title：Angiogenesis

authors： Fujita M,Ikemoto M,Tanaka T,Tamaki S,Yamazato A,Sawamura T,Hasegawa K,Kihara Y,Nohara R,Sasayama S

更新日期：1998-01-01 00:00:00