New anti-angiogenesis agents: review of the clinical experience with carboxyamido-triazole (CAI), thalidomide, TNP-470 and interleukin-12.

abstract：:Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vasculari...

journal_title：Angiogenesis

authors： Mao G,Liu Y,Fang X,Liu Y,Fang L,Lin L,Liu X,Wang N

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...

journal_title：Angiogenesis

authors： Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...

journal_title：Angiogenesis

authors： Ehling J,Misiewicz M,von Stillfried S,Möckel D,Bzyl J,Pochon S,Lederle W,Knuechel R,Lammers T,Palmowski M,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Although we reported that basic fibroblast growth factor (bFGF) levels in pericardial fluid of patients with unstable angina are apparently increased, it was unclear whether vascular endothelial growth factor (VEGF) is also increased in patients with myocardial ischemia. Using an enzyme-linked immunosorbent assay, we ...

journal_title：Angiogenesis

authors： Fujita M,Ikemoto M,Tanaka T,Tamaki S,Yamazato A,Sawamura T,Hasegawa K,Kihara Y,Nohara R,Sasayama S

更新日期：1998-01-01 00:00:00

abstract：:Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promisi...

journal_title：Angiogenesis

authors： Bocci M,Sjölund J,Kurzejamska E,Lindgren D,Marzouka NA,Bartoschek M,Höglund M,Pietras K

更新日期：2019-02-01 00:00:00

abstract：:Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...

journal_title：Angiogenesis

authors： Decaris ML,Lee CI,Yoder MC,Tarantal AF,Leach JK

更新日期：2009-01-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:Angiogenesis, or new blood vessel formation, is an important process in the pathogenesis of several diseases and thus has been targeted for the prevention and treatment for many disorders. However, the anti-angiogenic agents that are currently in use are mainly synthetic compounds and humanized monoclonal antibodies, ...

journal_title：Angiogenesis

authors： Lu K,Bhat M,Basu S

更新日期：2016-07-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...

journal_title：Angiogenesis

authors： García-Martínez E,Redondo A,Piulats JM,Rodríguez A,Casado A

更新日期：2020-11-01 00:00:00

abstract：:Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data exist regarding the effects of this drug on the growth of metastases in preclinical models. Here we use 4T1 and RENCA tumour cells, which both form lung metastas...

journal_title：Angiogenesis

authors： Welti JC,Powles T,Foo S,Gourlaouen M,Preece N,Foster J,Frentzas S,Bird D,Sharpe K,van Weverwijk A,Robertson D,Soffe J,Erler JT,Pili R,Springer CJ,Mather SJ,Reynolds AR

更新日期：2012-12-01 00:00:00

abstract：:Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...

journal_title：Angiogenesis

authors： Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

更新日期：1999-01-01 00:00:00

abstract：:Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...

journal_title：Angiogenesis

authors： Groothuis PG,Nap AW,Winterhager E,Grümmer R

更新日期：2005-01-01 00:00:00

abstract：:Endothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and ot...

journal_title：Angiogenesis

authors： Greenspan LJ,Weinstein BM

更新日期：2021-01-15 00:00:00

abstract：:The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins in...

journal_title：Angiogenesis

authors： Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MF

更新日期：2003-01-01 00:00:00

abstract：:Among the key effects of fluid shear stress on vascular endothelial cells is modulation of gene expression. Promoter sequences termed shear stress response elements (SSREs) mediate the responsiveness of endothelial genes to shear stress. While previous studies showed that shear stress responsiveness is mediated by a s...

journal_title：Angiogenesis

authors： Silberman M,Barac YD,Yahav H,Wolfovitz E,Einav S,Resnick N,Binah O

更新日期：2009-01-01 00:00:00

abstract：:Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...

journal_title：Angiogenesis

authors： Denbeigh JM,Nixon BA,Lee JJ,Jerkic M,Marsden PA,Letarte M,Puri MC,Foster FS

更新日期：2015-01-01 00:00:00

abstract：:CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...

journal_title：Angiogenesis

authors： Nanney LB,Wamil BD,Whitsitt J,Cardwell NL,Davidson JM,Yan HP,Hellerqvist CG

更新日期：2001-01-01 00:00:00

abstract：:Although monotherapy with angiostatic drugs is still far from effective, there is abundant evidence that angiostatic therapy can improve the efficacy of conventional treatments like radiotherapy. This has instigated numerous efforts to optimize and clinically implement the combination of angiostatic drugs with radiati...

journal_title：Angiogenesis

authors： Hamming LC,Slotman BJ,Verheul HMW,Thijssen VL

更新日期：2017-05-01 00:00:00

abstract：:During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α parti...

journal_title：Angiogenesis

authors： Nauta TD,van den Broek M,Gibbs S,van der Pouw-Kraan TC,Oudejans CB,van Hinsbergh VW,Koolwijk P

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:In patients with resectable colorectal liver metastases (CRLM), distinct histopathological growth patterns (HGPs) develop at the interface between the tumour and surrounding tissue. The desmoplastic (d) HGP is characterised by angiogenesis and a peripheral fibrotic rim, whereas non-angiogenic HGPs co-opt end...

journal_title：Angiogenesis

authors： Galjart B,Nierop PMH,van der Stok EP,van den Braak RRJC,Höppener DJ,Daelemans S,Dirix LY,Verhoef C,Vermeulen PB,Grünhagen DJ

更新日期：2019-05-01 00:00:00

abstract：:The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....

journal_title：Angiogenesis

authors： Li Q,Michaud M,Canosa S,Kuo A,Madri JA

更新日期：2011-05-01 00:00:00

abstract：:Inhibiting pathologic angiogenesis can halt disease progression, but such inhibition may offer only a temporary benefit, followed by tissue revascularization after treatment stoppage. This revascularization, however, occurs by largely unknown phenotypic changes in pathologic vessels. To investigate the dynamics of ves...

journal_title：Angiogenesis

authors： Mukwaya A,Mirabelli P,Lennikov A,Thangavelu M,Ntzouni M,Jensen L,Peebo B,Lagali N

更新日期：2019-11-01 00:00:00

abstract：:Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype d...

journal_title：Angiogenesis

authors： Kaspi E,Guillet B,Piercecchi-Marti MD,Alfaidy N,Bretelle F,Bertaud-Foucault A,Stalin J,Rambeloson L,Lacroix O,Blot-Chabaud M,Dignat-George F,Bardin N

更新日期：2013-04-01 00:00:00

abstract：:Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...

journal_title：Angiogenesis

authors： Willhauck-Fleckenstein M,Moehler TM,Merling A,Pusunc S,Goldschmidt H,Schwartz-Albiez R

更新日期：2010-03-01 00:00:00

abstract：:Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...

journal_title：Angiogenesis

authors： Afonyushkin T,Oskolkova OV,Bochkov VN

更新日期：2018-05-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic destructive musculo-skeletal disorder, associated with thickening of the synovial membrane lining the joints, inflammation and hyperproliferation of synovial cells, as well as a pro-inflammatory cytokine cascade, leukocyte infiltration, and tissue damage and bone resorption. An e...

journal_title：Angiogenesis

authors： Paleolog EM,Miotla JM

更新日期：1998-01-01 00:00:00

abstract：:Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...

journal_title：Angiogenesis

authors： Zhu XD,Sun HC,Xu HX,Kong LQ,Chai ZT,Lu L,Zhang JB,Gao DM,Wang WQ,Zhang W,Zhuang PY,Wu WZ,Wang L,Tang ZY

更新日期：2013-10-01 00:00:00

abstract：:The semaphorins and plexins comprise a family of cysteine-rich proteins implicated in control of nerve growth and development and regulation of the immune response. Our group and others have found that Semaphorin 4D (SEMA4D) and its receptor, Plexin-B1, play an important role in tumor-induced angiogenesis, with some n...

journal_title：Angiogenesis

authors： Zhou H,Binmadi NO,Yang YH,Proia P,Basile JR

更新日期：2012-09-01 00:00:00

abstract：:Intermittent Hypoxia (IH) that develops in neovascularized solid tumours has been described to positively influence the tumour growth by modulating the behaviour of cancer cells as well as of endothelial cells. However, the molecular mechanisms regulated by IH still remain poorly understood. In this work, the effects ...

journal_title：Angiogenesis

authors： Toffoli S,Delaive E,Dieu M,Feron O,Raes M,Michiels C

更新日期：2009-01-01 00:00:00