In vivo malignant phenotype of hst-1-transfected cells regulated by paracrine endothelial cell growth stimulation by HST-1.


:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimulating activity of TC-1-conditioned medium for endothelial cell DNA synthesis was approximately four times stronger than that of TC-2-conditioned medium and correlated with hst-1 mRNA expression levels. Other than endothelial cell growth stimulation, these two clones had similar typical in vitro transformed properties, with identical doubling times and morphological changes. When nude mice were injected s.c. with these clones, TC-1 cells revealed faster tumor formation and growth, compared to TC-2 cells which had less potential to promote endothelial cell growth. Furthermore, the life span of mice injected i.v. with TC-1 cells was shorter than those with TC-2 cells, resulting from progressive tumor growth in the lungs. This advanced malignant in vivo behavior of TC-1 cells may be mediated by the high angiogenic potential of TC-1 cells secreting larger amounts of HST-1 compared to TC-2 cells, suggesting that angiogenesis contributes to malignant progression of tumors.






Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG




Has Abstract


1998-01-01 00:00:00














  • Effects of topical administration of 12-methyl tetradecanoic acid (12-MTA) on the development of corneal angiogenesis.

    abstract::Corneal vascularisation is a potentially devastating occurrence that can cause blindness. Currently, treatments for this condition are limited. In these studies, we have investigated a novel inhibitor of angiogenesis, 12-methyl tetradecanoic acid (12-MTA), to treat corneal vascularisation in mouse models of corneal al...


    pub_type: 杂志文章


    authors: Cole N,Hume EB,Jalbert I,Vijay AK,Krishnan R,Willcox MD

    更新日期:2007-01-01 00:00:00

  • Inhibition of angiogenic initiation and disruption of newly established human vascular networks by juice from Morinda citrifolia (noni).

    abstract::noni, the juice of the fruit from the Morinda citrifolia plant, has been used for centuries as a medicinal agent. We tested the effects of noni juice in a three-dimensional fibrin clot matrix model using human placental vein and human breast tumor explants as sources for angiogenic vessel development. Noni in concentr...


    pub_type: 杂志文章


    authors: Hornick CA,Myers A,Sadowska-Krowicka H,Anthony CT,Woltering EA

    更新日期:2003-01-01 00:00:00

  • Visualizing vascular permeability and lymphatic drainage using labeled serum albumin.

    abstract::During the early stages of angiogenesis, following stimulation of endothelial cells by vascular endothelial growth factor (VEGF), the vascular wall is breached, allowing high molecular weight proteins to leak from the vessels to the interstitial space. This hallmark of angiogenesis results in deposition of a provision...


    pub_type: 杂志文章,评审


    authors: Vandoorne K,Addadi Y,Neeman M

    更新日期:2010-06-01 00:00:00

  • Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis.

    abstract:BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...


    pub_type: 杂志文章,meta分析


    authors: Yang JP,Liao YD,Mai DM,Xie P,Qiang YY,Zheng LS,Wang MY,Mei Y,Meng DF,Xu L,Cao L,Yang Q,Yang XX,Wang WB,Peng LX,Huang BJ,Qian CN

    更新日期:2016-04-01 00:00:00

  • Intramuscular fast-flow vascular anomaly contains somatic MAP2K1 and KRAS mutations.

    abstract:BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...


    pub_type: 杂志文章


    authors: Goss JA,Konczyk DJ,Smits PJ,Kozakewich HPW,Alomari AI,Al-Ibraheemi A,Taghinia AH,Dickie BH,Adams DM,Fishman SJ,Mulliken JB,Warman ML,Greene AK

    更新日期:2019-11-01 00:00:00

  • Contrast-enhanced molecular ultrasound differentiates endoglin genotypes in mouse embryos.

    abstract::Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...


    pub_type: 杂志文章


    authors: Denbeigh JM,Nixon BA,Lee JJ,Jerkic M,Marsden PA,Letarte M,Puri MC,Foster FS

    更新日期:2015-01-01 00:00:00

  • Strain differences and inheritance of angiogenic versus angiostatic activity in oestrogen-induced rat pituitary tumours.

    abstract::In this study we investigated the control of the angiogenic/haemorrhagic phenotype of oestrogen-induced rat pituitary tumours of an F1 hybrid (F1) of Fischer 344 (F344) (tumour susceptible) and Brown Norway (tumour resistant) strains. F1 forms a pituitary tumour upon chronic oestrogen treatment, but microvessel count ...


    pub_type: 杂志文章


    authors: Pandey J,Cracchiolo D,Hansen FM,Wendell DL

    更新日期:2002-01-01 00:00:00

  • Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer.

    abstract::Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...


    pub_type: 杂志文章


    authors: Sunamura M,Duda DG,Ghattas MH,Lozonschi L,Motoi F,Yamauchi J,Matsuno S,Shibahara S,Abraham NG

    更新日期:2003-01-01 00:00:00

  • Angiogenesis and endothelium phenotype expression in embryonic adrenal gland and cerebellum grafted onto chorioallantoic membrane.

    abstract::Vascularization and endothelial phenotype were investigated in embryonic tissues grafted onto chorioallantoic membrane (CAM) by means of immunocytochemistry and electron microscopy. Single grafts of adrenal gland or cerebellum and double grafts of adrenal gland plus cerebellum were performed, using tissues from chick ...


    pub_type: 杂志文章


    authors: Bertossi M,Virgintino D,Coltey P,Errede M,Mancini L,Roncali L

    更新日期:1999-01-01 00:00:00

  • The role of endoglin in post-ischemic revascularization.

    abstract::Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into ph...


    pub_type: 杂志文章,评审


    authors: Núñez-Gómez E,Pericacho M,Ollauri-Ibáñez C,Bernabéu C,López-Novoa JM

    更新日期:2017-02-01 00:00:00

  • New anti-angiogenesis agents: review of the clinical experience with carboxyamido-triazole (CAI), thalidomide, TNP-470 and interleukin-12.

    abstract::Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...


    pub_type: 杂志文章


    authors: Masiero L,Figg WD,Kohn EC

    更新日期:1997-01-01 00:00:00

  • Inflammation-induced lymphangiogenesis and lymphatic dysfunction.

    abstract::The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphati...


    pub_type: 杂志文章,评审


    authors: Liao S,von der Weid PY

    更新日期:2014-04-01 00:00:00

  • Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety.

    abstract::Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...


    pub_type: 杂志文章


    authors: Tang F,LeBlanc ME,Wang W,Liang D,Chen P,Chou TH,Tian H,Li W

    更新日期:2019-08-01 00:00:00

  • Ribonuclease 4 protects neuron degeneration by promoting angiogenesis, neurogenesis, and neuronal survival under stress.

    abstract::Altered RNA processing is an underlying mechanism of amyotrophic lateral sclerosis (ALS). Missense mutations in a number of genes involved in RNA function and metabolisms are associated with ALS. Among these genes is angiogenin (ANG), the fifth member of the vertebrate-specific, secreted ribonuclease superfamily. ANG ...


    pub_type: 杂志文章


    authors: Li S,Sheng J,Hu JK,Yu W,Kishikawa H,Hu MG,Shima K,Wu D,Xu Z,Xin W,Sims KB,Landers JE,Brown RH Jr,Hu GF

    更新日期:2013-04-01 00:00:00

  • Transcriptional profiling of human microvascular endothelial cells in the proliferative and quiescent state using cDNA arrays.

    abstract::Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...


    pub_type: 杂志文章


    authors: Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

    更新日期:1999-01-01 00:00:00

  • PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis.

    abstract::Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow fo...


    pub_type: 杂志文章


    authors: Cuervo H,Pereira B,Nadeem T,Lin M,Lee F,Kitajewski J,Lin CS

    更新日期:2017-11-01 00:00:00

  • Vascular development in endometriosis.

    abstract::Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...


    pub_type: 杂志文章,评审


    authors: Groothuis PG,Nap AW,Winterhager E,Grümmer R

    更新日期:2005-01-01 00:00:00

  • Identification of HIF-2α-regulated genes that play a role in human microvascular endothelial sprouting during prolonged hypoxia in vitro.

    abstract::During prolonged hypoxic conditions, endothelial cells change their gene expression to adjust to the low oxygen environment. This process is mainly regulated by the hypoxia-inducible factors, HIF-1α and HIF-2α. Although endothelial cells do not form sprouts during prolonged hypoxic culturing, silencing of HIF-2α parti...


    pub_type: 杂志文章


    authors: Nauta TD,van den Broek M,Gibbs S,van der Pouw-Kraan TC,Oudejans CB,van Hinsbergh VW,Koolwijk P

    更新日期:2017-02-01 00:00:00

  • Src activation of Stat3 is an independent requirement from NF-kappaB activation for constitutive IL-8 expression in human pancreatic adenocarcinoma cells.

    abstract::Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...


    pub_type: 杂志文章


    authors: Trevino JG,Gray MJ,Nawrocki ST,Summy JM,Lesslie DP,Evans DB,Sawyer TK,Shakespeare WC,Watowich SS,Chiao PJ,McConkey DJ,Gallick GE

    更新日期:2006-01-01 00:00:00

  • Capillary arterialization requires the bone-marrow-derived cell (BMC)-specific expression of chemokine (C-C motif) receptor-2, but BMCs do not transdifferentiate into microvascular smooth muscle.

    abstract::Chemokine (C-C motif) receptor-2 (CCR2) regulates arteriogenesis and angiogenesis, facilitating the MCP-1-dependent recruitment of growth factor-secreting bone marrow-derived cells (BMCs). Here, we tested the hypothesis that the BMC-specific expression of CCR2 is also required for new arteriole formation via capillary...


    pub_type: 杂志文章


    authors: Nickerson MM,Burke CW,Meisner JK,Shuptrine CW,Song J,Price RJ

    更新日期:2009-01-01 00:00:00

  • Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells.

    abstract::Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...


    pub_type: 杂志文章


    authors: Yao J,Guihard PJ,Blazquez-Medela AM,Guo Y,Liu T,Boström KI,Yao Y

    更新日期:2016-01-01 00:00:00

  • Genetic markers of bevacizumab-induced hypertension.

    abstract:PURPOSE:There are currently no validated biomarkers predicting bevacizumab treatment outcome or toxicity. We combined biomarker data from six phase III trials of bevacizumab to assess whether genetic variation in vascular endothelial growth factor-A (VEGF-A) pathway or hypertension-related genes are associated with bev...


    pub_type: 杂志文章


    authors: Lambrechts D,Moisse M,Delmar P,Miles DW,Leighl N,Escudier B,Van Cutsem E,Bansal AT,Carmeliet P,Scherer SJ,de Haas S,Pallaud C

    更新日期:2014-07-01 00:00:00

  • CLT1 targets angiogenic endothelium through CLIC1 and fibronectin.

    abstract::Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...


    pub_type: 杂志文章


    authors: Knowles LM,Malik G,Hood BL,Conrads TP,Pilch J

    更新日期:2012-03-01 00:00:00

  • To be or not to be: endothelial cell plasticity in development, repair, and disease.

    abstract::Endothelial cells display an extraordinary plasticity both during development and throughout adult life. During early development, endothelial cells assume arterial, venous, or lymphatic identity, while selected endothelial cells undergo additional fate changes to become hematopoietic progenitor, cardiac valve, and ot...


    pub_type: 杂志文章,评审


    authors: Greenspan LJ,Weinstein BM

    更新日期:2021-01-15 00:00:00

  • RCAN1.4 regulates VEGFR-2 internalisation, cell polarity and migration in human microvascular endothelial cells.

    abstract::Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is h...


    pub_type: 杂志文章


    authors: Alghanem AF,Wilkinson EL,Emmett MS,Aljasir MA,Holmes K,Rothermel BA,Simms VA,Heath VL,Cross MJ

    更新日期:2017-08-01 00:00:00

  • Pharmacological intervention of MKL/SRF signaling by CCG-1423 impedes endothelial cell migration and angiogenesis.

    abstract::De novo synthesis of cytoskeleton-regulatory proteins triggered by the megakaryoblastic leukemia (MKL)/serum response factor (SRF) transcriptional system in response to pro-angiogenic growth factors lies at the heart of endothelial cell (EC) migration (a critical element of angiogenesis) and neovascularization. This s...


    pub_type: 杂志文章


    authors: Gau D,Veon W,Capasso TL,Bottcher R,Shroff S,Roman BL,Roy P

    更新日期:2017-11-01 00:00:00

  • Transcriptional regulation of the vascular endothelial glycome by angiogenic and inflammatory signalling.

    abstract::Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...


    pub_type: 杂志文章


    authors: Willhauck-Fleckenstein M,Moehler TM,Merling A,Pusunc S,Goldschmidt H,Schwartz-Albiez R

    更新日期:2010-03-01 00:00:00

  • Angiogenesis in arthritis: role in disease pathogenesis and as a potential therapeutic target.

    abstract::Rheumatoid arthritis (RA) is a chronic destructive musculo-skeletal disorder, associated with thickening of the synovial membrane lining the joints, inflammation and hyperproliferation of synovial cells, as well as a pro-inflammatory cytokine cascade, leukocyte infiltration, and tissue damage and bone resorption. An e...


    pub_type: 杂志文章


    authors: Paleolog EM,Miotla JM

    更新日期:1998-01-01 00:00:00

  • Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation.

    abstract::The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...


    pub_type: 杂志文章


    authors: Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

    更新日期:2008-01-01 00:00:00

  • Mesenchymal stem cells from adipose and bone marrow promote angiogenesis via distinct cytokine and protease expression mechanisms.

    abstract::Using a fibrin-based angiogenesis model, we have established that there is no canonical mechanism used by endothelial cells (ECs) to degrade the surrounding extracellular matrix (ECM), but rather the set of proteases used is dependent on the mural cells providing the angiogenic cues. Mesenchymal stem cells (MSCs) orig...


    pub_type: 杂志文章


    authors: Kachgal S,Putnam AJ

    更新日期:2011-03-01 00:00:00