Abstract:
:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process has received renewed attention due to the suggested role of blood vessel co-option in resistance to antiangiogenic therapies and the reported perivascular positioning and migratory patterns of cancer cells during tumor dormancy and invasion, respectively. However, only a few molecular mechanisms have been identified that contribute to the process of co-option and there has not been a formal survey of cell lines and laboratory models that can be used to study co-option in different organ microenvironments; thus, we have carried out a comprehensive literature review on this topic and have identified cell lines and described the laboratory models that are used to study blood vessel co-option in cancer. Put into practice, these models may help to shed new light on the molecular mechanisms that drive blood vessel co-option during tumor dormancy, invasion, and responses to different therapies.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Zhang Y,Wang S,Dudley ACdoi
10.1007/s10456-019-09684-ysubject
Has Abstractpub_date
2020-02-01 00:00:00pages
17-25issue
1eissn
0969-6970issn
1573-7209pii
10.1007/s10456-019-09684-yjournal_volume
23pub_type
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