Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells.

abstract：:Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...

journal_title：Angiogenesis

authors： Decaris ML,Lee CI,Yoder MC,Tarantal AF,Leach JK

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial (VE) cadherin is a key component of endothelial adherens junctions (AJs) and plays an important role in maintaining vascular integrity. Endocytosis of VE-cadherin regulates junctional strength and a decrease of surface VE-cadherin reduces vascular stability. However, disruption of AJs is also a re...

journal_title：Angiogenesis

authors： Chrifi I,Louzao-Martinez L,Brandt MM,van Dijk CGM,Bürgisser PE,Zhu C,Kros JM,Verhaar MC,Duncker DJ,Cheng C

更新日期：2019-02-01 00:00:00

abstract：:During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...

journal_title：Angiogenesis

authors： Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld M

更新日期：2012-06-01 00:00:00

abstract：:Endothelial progenitor cells (EPCs) play a critical role in the repair of damaged blood vessels and/or in the growth of new ones in ischemic tissues. Elevated levels of oxygen radicals, which accumulate in the ischemic tissue, could compromise the angiogenic potential of EPCs. To determine if oxidative stress alters t...

journal_title：Angiogenesis

authors： Curatola AM,Xu J,Hendricks-Munoz KD

更新日期：2011-09-01 00:00:00

abstract：:Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

journal_title：Angiogenesis

authors： Masiero L,Figg WD,Kohn EC

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:In patients with resectable colorectal liver metastases (CRLM), distinct histopathological growth patterns (HGPs) develop at the interface between the tumour and surrounding tissue. The desmoplastic (d) HGP is characterised by angiogenesis and a peripheral fibrotic rim, whereas non-angiogenic HGPs co-opt end...

journal_title：Angiogenesis

authors： Galjart B,Nierop PMH,van der Stok EP,van den Braak RRJC,Höppener DJ,Daelemans S,Dirix LY,Verhoef C,Vermeulen PB,Grünhagen DJ

更新日期：2019-05-01 00:00:00

abstract：:Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...

journal_title：Angiogenesis

authors： Tang F,LeBlanc ME,Wang W,Liang D,Chen P,Chou TH,Tian H,Li W

更新日期：2019-08-01 00:00:00

abstract：:Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...

journal_title：Angiogenesis

authors： Willhauck-Fleckenstein M,Moehler TM,Merling A,Pusunc S,Goldschmidt H,Schwartz-Albiez R

更新日期：2010-03-01 00:00:00

abstract：:Sunitinib is a potent and clinically approved tyrosine kinase inhibitor that can suppress tumour growth by inhibiting angiogenesis. However, conflicting data exist regarding the effects of this drug on the growth of metastases in preclinical models. Here we use 4T1 and RENCA tumour cells, which both form lung metastas...

journal_title：Angiogenesis

authors： Welti JC,Powles T,Foo S,Gourlaouen M,Preece N,Foster J,Frentzas S,Bird D,Sharpe K,van Weverwijk A,Robertson D,Soffe J,Erler JT,Pili R,Springer CJ,Mather SJ,Reynolds AR

更新日期：2012-12-01 00:00:00

abstract：:The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...

journal_title：Angiogenesis

authors： Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

更新日期：2008-01-01 00:00:00

abstract：:The sprouting of endothelial cells from pre-existing blood vessels represents a critical event in the angiogenesis cascade. However, only a fraction of cultured or transplanted endothelial cells form new vessels. Moreover, it is unclear whether this results from a stochastic process or instead relates to certain endot...

journal_title：Angiogenesis

authors： Silva EA,Eseonu C,Mooney DJ

更新日期：2014-07-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR...

journal_title：Angiogenesis

authors： Ma T,Patel H,Babapoor-Farrokhran S,Franklin R,Semenza GL,Sodhi A,Montaner S

更新日期：2015-10-01 00:00:00

abstract：:Transmembrane-4 L-six family member-1 (TM4SF1) is a small plasma membrane glycoprotein that regulates cell motility and proliferation. TM4SF1 is an attractive cancer target because of its high expression in both tumor cells and on the vascular endothelial cells lining tumor blood vessels. We generated mouse monoclonal...

journal_title：Angiogenesis

authors： Lin CI,Merley A,Sciuto TE,Li D,Dvorak AM,Melero-Martin JM,Dvorak HF,Jaminet SC

更新日期：2014-10-01 00:00:00

abstract：:Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

journal_title：Angiogenesis

authors： Pavlakovic H,Havers W,Schweigerer L

更新日期：2001-01-01 00:00:00

abstract：:Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macu...

journal_title：Angiogenesis

authors： Adamis AP,Aiello LP,D'Amato RA

更新日期：1999-01-01 00:00:00

abstract：:The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...

journal_title：Angiogenesis

authors： Persigehl T,Ring J,Bremer C,Heindel W,Holtmeier R,Stypmann J,Claesener M,Hermann S,Schäfers M,Zerbst C,Schliemann C,Mesters RM,Berdel WE,Schwöppe C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Angiogenesis plays a pivotal role in neoplastic growth and metastasis formation. Vascular endothelial growth factor A (VEGFA) is a major player in physiological and tumour-induced angiogenesis and numerous human tumours have been show to overexpress VEGFA. Moreover increased VEGFA gene expression has been fo...

journal_title：Angiogenesis

authors： Andreozzi M,Quagliata L,Gsponer JR,Ruiz C,Vuaroqueaux V,Eppenberger-Castori S,Tornillo L,Terracciano LM

更新日期：2014-07-01 00:00:00

abstract：INTRODUCTION:Alterations in vascular morphogenesis are hallmarks of antiangiogenesis-resistant tumor vessels. Vascular morphogenesis is regulated by ephrinB2-EphB4 system which may induce different biological effects depending on the oncological and molecular contexts. It was the aim of the current study to characteriz...

journal_title：Angiogenesis

authors： Uhl C,Markel M,Broggini T,Nieminen M,Kremenetskaia I,Vajkoczy P,Czabanka M

更新日期：2018-11-01 00:00:00

abstract：:Cancer cells have diverse mechanisms for utilizing the vasculature; they can initiate the formation of new blood vessels from preexisting ones (sprouting angiogenesis) or they can form cohesive interactions with the abluminal surface of preexisting vasculature in the absence of sprouting (co-option). The later process...

journal_title：Angiogenesis

authors： Zhang Y,Wang S,Dudley AC

更新日期：2020-02-01 00:00:00

abstract：:Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...

journal_title：Angiogenesis

authors： Sunamura M,Duda DG,Ghattas MH,Lozonschi L,Motoi F,Yamauchi J,Matsuno S,Shibahara S,Abraham NG

更新日期：2003-01-01 00:00:00

abstract：INTRODUCTION:Clinical and pathological characteristics are still considered prognostic markers in metastatic non-small-cell lung cancer (NSCLC) patients but they cannot explain all interindividual variability. Tumoral angiogenesis mediated by the vascular endothelial growth factor (VEGF) is critical for the progression...

journal_title：Angiogenesis

authors： Sullivan I,Riera P,Andrés M,Altés A,Majem M,Blanco R,Capdevila L,Barba A,Barnadas A,Salazar J

更新日期：2019-08-01 00:00:00

abstract：:Immunostaining with endothelial and pericyte markers was used to evaluate the cellular composition of angiogenic sprouts in several types of tumors and in the developing retina. Confocal microscopy revealed that, in addition to conventional endothelial tubes heavily invested by pericytes, all tissues contained small p...

journal_title：Angiogenesis

authors： Ozerdem U,Stallcup WB

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The term "intramuscular hemangioma capillary type" (IHCT) refers to a fast-flow vascular lesion that is classified as a tumor, although its phenotype overlaps with arteriovenous malformation (AVM). The purpose of this study was to identify somatic mutations in IHCT. METHODS:Affected tissue specimens were ob...

journal_title：Angiogenesis

authors： Goss JA,Konczyk DJ,Smits PJ,Kozakewich HPW,Alomari AI,Al-Ibraheemi A,Taghinia AH,Dickie BH,Adams DM,Fishman SJ,Mulliken JB,Warman ML,Greene AK

更新日期：2019-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...

journal_title：Angiogenesis

authors： Miwa D,Sakaue T,Inoue H,Takemori N,Kurokawa M,Fukuda S,Omi K,Goishi K,Higashiyama S

更新日期：2013-07-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...

journal_title：Angiogenesis

authors： Ehling J,Misiewicz M,von Stillfried S,Möckel D,Bzyl J,Pochon S,Lederle W,Knuechel R,Lammers T,Palmowski M,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Therapeutic over-expression of vascular endothelial growth factor (VEGF) can be used to treat ischemic conditions. However, VEGF can induce either normal or aberrant angiogenesis depending on its dose in the microenvironment around each producing cell in vivo, which limits its clinical usefulness. The goal herein was ...

journal_title：Angiogenesis

authors： Gianni-Barrera R,Trani M,Fontanellaz C,Heberer M,Djonov V,Hlushchuk R,Banfi A

更新日期：2013-01-01 00:00:00

abstract：:Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...

journal_title：Angiogenesis

authors： Herz K,Becker A,Shi C,Ema M,Takahashi S,Potente M,Hesse M,Fleischmann BK,Wenzel D

更新日期：2018-05-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...

journal_title：Angiogenesis

authors： Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

更新日期：2020-05-01 00:00:00