Abstract:
:During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blood endothelial cells (BEC) and lymphatic endothelial cells (LEC) have been reported. Since phenotypic plasticity and cellular differentiation processes frequently involve epigenetic mechanisms, we hypothesized that DNA methylation might play a role in regulating cell type-specific expression in endothelial cells. By analyzing global gene expression and methylation patterns of primary human dermal LEC and BEC, we identified a highly significant set of genes, which were differentially methylated and expressed. Pathway analyses of the differentially methylated and upregulated genes in LEC revealed involvement in developmental and transdifferentiation processes. We further identified a set of novel genes, which might be implicated in regulating BEC-LEC plasticity and could serve as therapeutic targets and/or biomarkers in vascular diseases associated with alterations in the endothelial phenotype.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Brönneke S,Brückner B,Peters N,Bosch TC,Stäb F,Wenck H,Hagemann S,Winnefeld Mdoi
10.1007/s10456-012-9264-2subject
Has Abstractpub_date
2012-06-01 00:00:00pages
317-29issue
2eissn
0969-6970issn
1573-7209journal_volume
15pub_type
临床试验,杂志文章相关文献
ANGIOGENESIS文献大全abstract:BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...
journal_title:Angiogenesis
pub_type: 杂志文章,meta分析
doi:10.1007/s10456-016-9500-2
更新日期:2016-04-01 00:00:00
abstract::The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9201-9
更新日期:2011-05-01 00:00:00
abstract::Angiogenesis, a crucial step in tumor growth and metastasis, is regulated by various pro- or anti-angiogenic factors. Recently, microRNAs have been shown to modulate angiogenic processes by modulating the expression of critical angiogenic factors. However, roles of tumor-derived microRNAs in regulating tumor vasculari...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9474-5
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9154-4
更新日期:2009-01-01 00:00:00
abstract::Using a fibrin-based angiogenesis model, we have established that there is no canonical mechanism used by endothelial cells (ECs) to degrade the surrounding extracellular matrix (ECM), but rather the set of proteases used is dependent on the mural cells providing the angiogenic cues. Mesenchymal stem cells (MSCs) orig...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-010-9194-9
更新日期:2011-03-01 00:00:00
abstract::The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-014-9440-7
更新日期:2014-10-01 00:00:00
abstract::Cancer cells sustain their metabolic needs through nutrients and oxygen supplied by the bloodstream. The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. Despite promisi...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章
doi:10.1007/s10456-018-9642-5
更新日期:2019-02-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9345-x
更新日期:2013-07-01 00:00:00
abstract::In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9492-3
更新日期:2016-04-01 00:00:00
abstract::The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9630-9
更新日期:2018-11-01 00:00:00
abstract::Technology has caught up with retinal diseases of neovasculature. Work with anti-cancer, anti-angiogenic agents has fueled the way for ocular therapeutics. The market size for age-related macular degeneration and diabetic retinopathy is huge. Fifteen million people in the United States alone have age-related macular d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-007-9068-y
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:EPLIN (epithelial protein lost in neoplasm) is a cytoskeletal associated protein involved in the regulation of actin dynamics and subsequently in cell motility. EPLIN expression is frequently reduced in a variety of cancer cells and tissues and this loss may account for increased invasive traits in cancer ce...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-010-9188-7
更新日期:2010-12-01 00:00:00
abstract::Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-017-9590-5
更新日期:2018-05-01 00:00:00
abstract::Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9484-3
更新日期:2016-01-01 00:00:00
abstract::The role of muscle contraction, prostanoids, nitric oxide and adenosine in the regulation of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) and endothelial cell proliferative compounds in skeletal muscle cell cultures was examined. VEGF and bFGF mRNA, protein release as well as the pr...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-004-4184-4
更新日期:2004-01-01 00:00:00
abstract::Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-020-09734-w
更新日期:2020-11-01 00:00:00
abstract::Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1009085422384
更新日期:1999-01-01 00:00:00
abstract::Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-010-9166-0
更新日期:2010-06-01 00:00:00
abstract::Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9606-9
更新日期:2018-08-01 00:00:00
abstract::Ocular angiogenesis is responsible for the majority of irreversible blindness in the developed world [1]. This debilitating complication affects all age groups and characterizes such diverse and widespread diseases as trachoma, retinopathy of prematurity, diabetic retinopathy, neovascular glaucoma and age-related macu...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1009071601454
更新日期:1999-01-01 00:00:00
abstract::Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s10456-018-9646-1
更新日期:2019-02-01 00:00:00
abstract::Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests ...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-005-9005-x
更新日期:2005-01-01 00:00:00
abstract::Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-9010-0
更新日期:2005-01-01 00:00:00
abstract::CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1016752925761
更新日期:2001-01-01 00:00:00
abstract::Intermittent Hypoxia (IH) that develops in neovascularized solid tumours has been described to positively influence the tumour growth by modulating the behaviour of cancer cells as well as of endothelial cells. However, the molecular mechanisms regulated by IH still remain poorly understood. In this work, the effects ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9156-2
更新日期:2009-01-01 00:00:00
abstract::Antiangiogenic therapy, specially sorafenib, has become the standard of care for patients with advanced hepatocellular carcinoma (HCC), however, the improvement in survival time is not satisfactory. Previous studies have found that, in some circumstances, antiangiogenic therapy promoted tumor metastasis and the mechan...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9357-6
更新日期:2013-10-01 00:00:00
abstract::Transmembrane-4-L-six-family-1 (TM4SF1) is a tetraspanin-like membrane protein that is highly and selectively expressed by cultured endothelial cells (EC) and, in vivo, by EC lining angiogenic tumor blood vessels. TM4SF1 is necessary for the formation of unusually long (up to a 50 μm), thin (~100-300 nm wide), F-actin...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9218-0
更新日期:2011-09-01 00:00:00
abstract:BACKGROUND:In patients with resectable colorectal liver metastases (CRLM), distinct histopathological growth patterns (HGPs) develop at the interface between the tumour and surrounding tissue. The desmoplastic (d) HGP is characterised by angiogenesis and a peripheral fibrotic rim, whereas non-angiogenic HGPs co-opt end...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09661-5
更新日期:2019-05-01 00:00:00
abstract::Angiopoietin-like (ANGPTL) proteins are secreted proteins showing structural similarity to members of the angiopoietin family. Some ANGPTL proteins possess pleiotropic activities, being involved in cancer lipid, glucose energy metabolisms, and angiogenesis. ANGPTL7 is the less characterized member of the family whose ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9435-4
更新日期:2014-10-01 00:00:00
abstract:INTRODUCTION:Clinical and pathological characteristics are still considered prognostic markers in metastatic non-small-cell lung cancer (NSCLC) patients but they cannot explain all interindividual variability. Tumoral angiogenesis mediated by the vascular endothelial growth factor (VEGF) is critical for the progression...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09668-y
更新日期:2019-08-01 00:00:00