Abstract:
:Immunostaining with endothelial and pericyte markers was used to evaluate the cellular composition of angiogenic sprouts in several types of tumors and in the developing retina. Confocal microscopy revealed that, in addition to conventional endothelial tubes heavily invested by pericytes, all tissues contained small populations of endothelium-free pericyte tubes in which nerve/glial antigen 2 (NG2) positive, platelet-derived growth factor beta (PDGF beta ) receptor-positive perivascular cells formed the lumen of the microvessel. Perfusion of tumor-bearing mice with FITC-dextran, followed by immunohistochemical staining of tumor vasculature, demonstrated direct apposition of pericytes to FITC-dextran in the lumen, confirming functional connection of the pericyte tube to the circulation. Transplantation of prostate and mammary tumor fragments into NG2-null mice led to the formation of tumor microvasculature that was invariably NG2-negative, demonstrating that pericytes associated with tumor microvessels are derived from the host rather than from the conversion of tumor cells to a pericyte phenotype. The existence of pericyte tubes reflects the early participation of pericytes in the process of angiogenic sprouting. The ability to study these precocious contributions of pericytes to neovascularization depends heavily on the use of NG2 and PDGF beta -receptor as reliable early markers for activated pericytes.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Ozerdem U,Stallcup WBdoi
10.1023/B:AGEN.0000021401.58039.a9subject
Has Abstractpub_date
2003-01-01 00:00:00pages
241-9issue
3eissn
0969-6970issn
1573-7209pii
5265361journal_volume
6pub_type
杂志文章相关文献
ANGIOGENESIS文献大全abstract::Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9345-x
更新日期:2013-07-01 00:00:00
abstract::The neurogenic areas of the brain are highly organized structures in which there is dynamic reciprocal modulation of neural stem cells (NSC) and microvascular endothelial cells (BEC) resulting in control of neural stem cell and vascular proliferation, survival and differentiation throughout the life of the individual....
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9201-9
更新日期:2011-05-01 00:00:00
abstract::Due to spatial tumor heterogeneity and consecutive sampling errors, it is critically important to assess treatment response following antiangiogenic therapy in three dimensions as two-dimensional assessment has been shown to substantially over- and underestimate treatment response. In this study, we evaluated whether ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-017-9566-5
更新日期:2017-11-01 00:00:00
abstract::Human pancreatic tumors often overexpress the angiogenesis-promoting factor Interleukin 8 (IL-8), in part due to overexpression of NF-kappaB, a frequent occurrence in pancreatic adenocarcinoma. In this study, we demonstrate that reducing c-Src kinase activity, through either pharmacologic inhibition or small interferi...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-006-9038-9
更新日期:2006-01-01 00:00:00
abstract::Inhibition of angiogenesis has become a major target in experimental cancer therapies. Vascular endothelial growth factor (VEGF) and its receptors are essential for breast cancer progression and relevant targets in experimental anti-angiogenesis. VEGF, produced by carcinoma cells, acts in a paracrine fashion on endoth...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-9010-0
更新日期:2005-01-01 00:00:00
abstract::Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as intera...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-013-9401-6
更新日期:2014-07-01 00:00:00
abstract::Transmembrane-4-L-six-family-1 (TM4SF1) is a tetraspanin-like membrane protein that is highly and selectively expressed by cultured endothelial cells (EC) and, in vivo, by EC lining angiogenic tumor blood vessels. TM4SF1 is necessary for the formation of unusually long (up to a 50 μm), thin (~100-300 nm wide), F-actin...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-011-9218-0
更新日期:2011-09-01 00:00:00
abstract::Following arterial occlusion, blood vessels respond by forming a new network of functional capillaries (angiogenesis), by reorganizing preexisting capillaries through the recruitment of smooth muscle cells to generate new arteries (arteriogenesis) and by growing and remodeling preexisting collateral arterioles into ph...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-016-9535-4
更新日期:2017-02-01 00:00:00
abstract::The sprouting of endothelial cells is the first step of tumor angiogenesis. Our previous study suggests that miR-153 suppresses breast tumor angiogenesis partially through targeting hypoxia-induced factor (HIF1α). In this study, we demonstrated that miR-153 also suppresses the migration and the tube formation of endot...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9630-9
更新日期:2018-11-01 00:00:00
abstract::The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphati...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-014-9416-7
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09704-x
更新日期:2020-05-01 00:00:00
abstract::During embryonic development, the lymphatic system emerges by transdifferentiation from the cardinal vein. Although lymphatic and blood vasculature share a close molecular and developmental relationship, they display distinct features and functions. However, even after terminal differentiation, transitions between blo...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章
doi:10.1007/s10456-012-9264-2
更新日期:2012-06-01 00:00:00
abstract::Inflammation in the normally immune-privileged cornea can initiate a pathologic angiogenic response causing vision-threatening corneal neovascularization. Inflammatory pathways, however, are numerous, complex and are activated in a time-dependent manner. Effective resolution of inflammation and associated angiogenesis...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9604-y
更新日期:2018-05-01 00:00:00
abstract::Pazopanib (Votrient) is an orally administered tyrosine kinase inhibitor that blocks VEGF receptors potentially serving as anti-angiogenic treatment for hereditary hemorrhagic telangiectasia (HHT). We report a prospective, multi-center, open-label, dose-escalating study [50 mg, 100 mg, 200 mg, and 400 mg], designed as...
journal_title:Angiogenesis
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1007/s10456-018-9646-1
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-009-9154-4
更新日期:2009-01-01 00:00:00
abstract::Targeted ultrasound contrast imaging has the potential to become a reliable molecular imaging tool. A better understanding of the quantitative aspects of molecular ultrasound technology could facilitate the translation of this technique to the clinic for the purposes of assessing vascular pathology and detecting indiv...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-014-9447-0
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:In patients with resectable colorectal liver metastases (CRLM), distinct histopathological growth patterns (HGPs) develop at the interface between the tumour and surrounding tissue. The desmoplastic (d) HGP is characterised by angiogenesis and a peripheral fibrotic rim, whereas non-angiogenic HGPs co-opt end...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09661-5
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:Vasculogenic mimicry (VM) is the formation of vascular channels by tumor cells or tumor cell-derived, trans-differentiated cells in highly aggressive, solid tumors. However, the disease features and prognostic value of VM for overall survival of cancer patients remain controversial. METHOD:To systematically...
journal_title:Angiogenesis
pub_type: 杂志文章,meta分析
doi:10.1007/s10456-016-9500-2
更新日期:2016-04-01 00:00:00
abstract::The fusion protein tTF-NGR consists of the extracellular domain of the thrombogenic human tissue factor (truncated tissue factor, tTF) and the peptide GNGRAHA (NGR), a ligand of the surface protein CD13 (aminopeptidase N), upregulated on endothelial cells of tumor vessels. tTF-NGR preferentially activates blood coagul...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-013-9391-4
更新日期:2014-01-01 00:00:00
abstract::Vascularization and endothelial phenotype were investigated in embryonic tissues grafted onto chorioallantoic membrane (CAM) by means of immunocytochemistry and electron microscopy. Single grafts of adrenal gland or cerebellum and double grafts of adrenal gland plus cerebellum were performed, using tissues from chick ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1026550510585
更新日期:1999-01-01 00:00:00
abstract::CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig,...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1016752925761
更新日期:2001-01-01 00:00:00
abstract::Molecular imaging agents are extending the potential of noninvasive medical diagnosis from basic gross anatomical descriptions to complicated phenotypic characterizations based upon the recognition of unique cell-surface biochemical signatures. Although originally the purview of nuclear medicine, "molecular imaging" i...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-010-9166-0
更新日期:2010-06-01 00:00:00
abstract::Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1023/a:1016045012466
更新日期:2001-01-01 00:00:00
abstract::In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-015-9492-3
更新日期:2016-04-01 00:00:00
abstract::Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-005-9024-7
更新日期:2005-01-01 00:00:00
abstract::Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-016-9499-4
更新日期:2016-04-01 00:00:00
abstract::Endothelial cell proliferation is a key process during vascular growth but its kinetics could only be assessed in vitro or ex vivo so far. To enable the monitoring and quantification of cell cycle kinetics in vivo, we have generated transgenic mice expressing an eGFP-anillin construct under control of the endothelial-...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-018-9601-1
更新日期:2018-05-01 00:00:00
abstract::Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...
journal_title:Angiogenesis
pub_type: 杂志文章,评审
doi:10.1007/s10456-007-9074-0
更新日期:2007-01-01 00:00:00
abstract::Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-019-09662-4
更新日期:2019-08-01 00:00:00
abstract::Regulator of calcineurin 1 (RCAN1) is an endogenous inhibitor of the calcineurin pathway in cells. It is expressed as two isoforms in vertebrates: RCAN1.1 is constitutively expressed in most tissues, whereas transcription of RCAN1.4 is induced by several stimuli that activate the calcineurin-NFAT pathway. RCAN1.4 is h...
journal_title:Angiogenesis
pub_type: 杂志文章
doi:10.1007/s10456-017-9542-0
更新日期:2017-08-01 00:00:00