Pazopanib may reduce bleeding in hereditary hemorrhagic telangiectasia.

abstract：:Angiogenesis is a complex process involving coordinated steps of endothelial cell activation, proliferation, migration, tube formation and capillary sprouting with participation of intracellular signaling pathways. Regulation of angiogenesis carries tremendous potential for cancer therapy. Our earlier studies showed t...

journal_title：Angiogenesis

authors： Kalkunte S,Brard L,Granai CO,Swamy N

更新日期：2005-01-01 00:00:00

abstract：:Human ribonuclease inhibitor (hRI) can inhibit angiogenesis by reversibly binding angiogenin, a member of the RNaseA superfamily, and by suppressing the expression of basic fibroblast growth factor (bFGF). Angiogenesis is necessary for the growth and metastasis of tumors. To study the links between hRI, angiogenesis, ...

journal_title：Angiogenesis

authors： Wang T,Yang M,Chen J,Watkins T,Xiuyun C

更新日期：2005-01-01 00:00:00

abstract：:The formation of new tubular structures from a quiescent endothelial lining is one of the hallmarks of sprouting angiogenesis. This process can be mimicked in vitro by inducing capillary-like tubular structures in a three-dimensional (3D) fibrin matrix. We aimed to analyze the differential mRNA expression in two pheno...

journal_title：Angiogenesis

authors： Engelse MA,Laurens N,Verloop RE,Koolwijk P,van Hinsbergh VW

更新日期：2008-01-01 00:00:00

abstract：:Angiogenesis was postulated to be a critical prognostic factor and therapeutic focus for malignancy more than two decades ago. Recent studies indicate quantitative assessments of microvessel count to be an independent prognostic variable for disease-free and overall survival in a wide variety of tumors, and that angio...

journal_title：Angiogenesis

authors： Masiero L,Figg WD,Kohn EC

更新日期：1997-01-01 00:00:00

abstract：:Angiogenesis is important for tumor growth and metastasis. CLT1 (CGLIIQKNEC), a peptide that binds to tumor interstitial spaces in the presence of fibrin-fibronectin, has structural similarity to the anti-angiogenic β-sheet peptides anastellin and anginex. This similarity is reflected in the ability of CLT1 to form co...

journal_title：Angiogenesis

authors： Knowles LM,Malik G,Hood BL,Conrads TP,Pilch J

更新日期：2012-03-01 00:00:00

abstract：:Intermittent Hypoxia (IH) that develops in neovascularized solid tumours has been described to positively influence the tumour growth by modulating the behaviour of cancer cells as well as of endothelial cells. However, the molecular mechanisms regulated by IH still remain poorly understood. In this work, the effects ...

journal_title：Angiogenesis

authors： Toffoli S,Delaive E,Dieu M,Feron O,Raes M,Michiels C

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial cells undergo many molecular changes during pathological processes such as inflammation and tumour development. Tumours such as malignant lymphomas affecting bone marrow are dependent on interactions with endothelial cells for (1) site-specific homing and (2) tumour-induced angiogenesis. Modificat...

journal_title：Angiogenesis

authors： Willhauck-Fleckenstein M,Moehler TM,Merling A,Pusunc S,Goldschmidt H,Schwartz-Albiez R

更新日期：2010-03-01 00:00:00

abstract：:The sprouting of endothelial cells from pre-existing blood vessels represents a critical event in the angiogenesis cascade. However, only a fraction of cultured or transplanted endothelial cells form new vessels. Moreover, it is unclear whether this results from a stochastic process or instead relates to certain endot...

journal_title：Angiogenesis

authors： Silva EA,Eseonu C,Mooney DJ

更新日期：2014-07-01 00:00:00

abstract：:The chicken chorioallantoic membrane (CAM) is a simple, highly vascularized extraembryonic membrane, which performs multiple functions during embryonic development, including but not restricted to gas exchange. Over the last two decades, interest in the CAM as a robust experimental platform to study blood vessels has ...

journal_title：Angiogenesis

authors： Nowak-Sliwinska P,Segura T,Iruela-Arispe ML

更新日期：2014-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a major angiogenic factor that activates pro-angiogenic molecules to generate new vessels. Recently, we identified a VEGF-A-induced pro-angiogenic gene, BCL-6 associated zinc finger protein (BAZF), in endothelial cells. BAZF interacts with CBF1, a transcriptional regulator ...

journal_title：Angiogenesis

authors： Miwa D,Sakaue T,Inoue H,Takemori N,Kurokawa M,Fukuda S,Omi K,Goishi K,Higashiyama S

更新日期：2013-07-01 00:00:00

abstract：:Pericytes are essential mural cells distinguished by their association with small caliber blood vessels and the presence of a basement membrane shared with endothelial cells. Pericyte interaction with the endothelium plays an important role in angiogenesis; however, very few tools are currently available that allow fo...

journal_title：Angiogenesis

authors： Cuervo H,Pereira B,Nadeem T,Lin M,Lee F,Kitajewski J,Lin CS

更新日期：2017-11-01 00:00:00

abstract：:The hst-1 gene product, one of the fibroblast growth factor family proteins, has transforming and angiogenic activities. The BALB/c 3T3 cell line was transfected with an expression vector harboring human hst-1 cDNA and the malignant properties of two stably transfected clones, TC-1 and TC-2, were examined. The stimula...

journal_title：Angiogenesis

authors： Aonuma M,Murakami K,Hirotani K,Horiuchi T,Sakamoto H,Terada M,Tanaka NG

更新日期：1998-01-01 00:00:00

abstract：INTRODUCTION:Although thioredoxin-interacting protein (TXNIP) is involved in a variety of biological functions, the contribution of endothelial TXNIP has not been well-defined in regards to endothelial and vascular function or in post-ischemic revascularisation. We postulated that inhibition of endothelial TXNIP with s...

journal_title：Angiogenesis

authors： Domingues A,Boisson-Vidal C,Marquet de Rouge P,Dizier B,Sadoine J,Mignon V,Vessières E,Henrion D,Escriou V,Bigey P,Chaussain C,Smadja DM,Nivet-Antoine V

更新日期：2020-05-01 00:00:00

abstract：:Matrix Gla protein (MGP) is an antagonist of bone morphogenetic proteins and expressed in vascular endothelial cells. Lack of MGP causes vascular abnormalities in multiple organs in mice. The objective of this study is to define the role of MGP in early endothelial differentiation. We find that expression of endotheli...

journal_title：Angiogenesis

authors： Yao J,Guihard PJ,Blazquez-Medela AM,Guo Y,Liu T,Boström KI,Yao Y

更新日期：2016-01-01 00:00:00

abstract：:In the adult, new vessels and red blood cells form in response to hypoxia. Here, the oxygen-sensing system (PHD-HIF) has recently been put into focus, since the prolyl-hydroxylase domain proteins (PHD) and hypoxia-inducible factors (HIF) are considered as potential therapeutic targets to treat ischemia, cancers or age...

journal_title：Angiogenesis

authors： Metikala S,Neuhaus H,Hollemann T

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factor receptor 2 (VEGFR-2) and α v ß 3 integrin are the most frequently addressed targets in molecular imaging of tumor angiogenesis. In preclinical studies, molecular imaging of angiogenesis has shown potential to detect and differentiate benign and malignant lesions of the breast. Thus, ...

journal_title：Angiogenesis

authors： Ehling J,Misiewicz M,von Stillfried S,Möckel D,Bzyl J,Pochon S,Lederle W,Knuechel R,Lammers T,Palmowski M,Kiessling F

更新日期：2016-04-01 00:00:00

abstract：:Vascular endothelial growth factors (VEGFs) regulate blood and lymph vessel development upon activation of three receptor tyrosine kinases (VEGFRs). The extracellular domain of VEGFRs consists of seven Ig-homology domains, of which D2-3 form the ligand-binding site, while the membrane proximal domains D4-7 are involve...

journal_title：Angiogenesis

authors： Thieltges KM,Avramovic D,Piscitelli CL,Markovic-Mueller S,Binz HK,Ballmer-Hofer K

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:Dysregulation of the phosphatidylinositol-3-kinase (PI3K) signaling pathway is a hallmark of human cancer, occurring in a majority of tumors. Activation of this pathway is critical for transformation and also for the angiogenic switch, which is a key step for tumor progression. The objective of this study was...

journal_title：Angiogenesis

authors： Harfouche R,Basu S,Soni S,Hentschel DM,Mashelkar RA,Sengupta S

更新日期：2009-01-01 00:00:00

abstract：:Anti-angiogenesis is likely to develop into a novel therapeutic approach for patients with solid malignancies. Most current clinical trials evaluate anti-angiogenic drugs aimed primarily against single angiogenesis stimulators. Here, we show that a single solid malignancy, i.e., a human embryonal rhabdomyosarcoma, pro...

journal_title：Angiogenesis

authors： Pavlakovic H,Havers W,Schweigerer L

更新日期：2001-01-01 00:00:00

abstract：:Kaposi's sarcoma (KS) is a vascular neoplasm caused by infection of endothelial or endothelial precursor cells with the Kaposi's sarcoma-associated herpesvirus (KSHV/HHV8). Research efforts have focused on defining the molecular events explaining how KSHV promotes pathological angiogenesis and KS tumor formation. mTOR...

journal_title：Angiogenesis

authors： Ma T,Patel H,Babapoor-Farrokhran S,Franklin R,Semenza GL,Sodhi A,Montaner S

更新日期：2015-10-01 00:00:00

abstract：:Evidence has been gathered regarding the association between angiogenesis and inflammation in pathological situations. These two phenomena have long been coupled together in many chronic inflammatory disorders with distinct etiopathogenic origin, including psoriasis, rheumatoid arthritis, Crohn's disease, diabetes, an...

journal_title：Angiogenesis

authors： Costa C,Incio J,Soares R

更新日期：2007-01-01 00:00:00

abstract：:Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, we used the vital microscope system, transparent skinfold model, lung colonization model and transduced pancre...

journal_title：Angiogenesis

authors： Sunamura M,Duda DG,Ghattas MH,Lozonschi L,Motoi F,Yamauchi J,Matsuno S,Shibahara S,Abraham NG

更新日期：2003-01-01 00:00:00

abstract：:Using a fibrin-based angiogenesis model, we have established that there is no canonical mechanism used by endothelial cells (ECs) to degrade the surrounding extracellular matrix (ECM), but rather the set of proteases used is dependent on the mural cells providing the angiogenic cues. Mesenchymal stem cells (MSCs) orig...

journal_title：Angiogenesis

authors： Kachgal S,Putnam AJ

更新日期：2011-03-01 00:00:00

abstract：:Receptor tyrosine kinase c-Kit and its ligand stem cell factor (SCF) regulate resident vascular wall cells and recruit circulating progenitors. We tested whether SCF may be induced by oxidized palmitoyl-arachidonoyl-phosphatidylcholine (OxPAPC) known to accumulate in atherosclerotic vessels. Gene expression analysis d...

journal_title：Angiogenesis

authors： Afonyushkin T,Oskolkova OV,Bochkov VN

更新日期：2018-05-01 00:00:00

abstract：:In this study we investigated the control of the angiogenic/haemorrhagic phenotype of oestrogen-induced rat pituitary tumours of an F1 hybrid (F1) of Fischer 344 (F344) (tumour susceptible) and Brown Norway (tumour resistant) strains. F1 forms a pituitary tumour upon chronic oestrogen treatment, but microvessel count ...

journal_title：Angiogenesis

authors： Pandey J,Cracchiolo D,Hansen FM,Wendell DL

更新日期：2002-01-01 00:00:00

abstract：:Retinopathy of prematurity (ROP) with pathological retinal neovascularization is the most common cause of blindness in children. ROP is currently treated with laser therapy or cryotherapy, both of which may adversely affect the peripheral vision with limited efficacy. Owing to the susceptibility of the developing reti...

journal_title：Angiogenesis

authors： Tang F,LeBlanc ME,Wang W,Liang D,Chen P,Chou TH,Tian H,Li W

更新日期：2019-08-01 00:00:00

abstract：:Ovarian cancer (OC) is associated with poor survival because there are a limited number of effective therapies. Two processes key to OC progression, angiogenesis and immune evasion, act synergistically to promote tumor progression. Tumor-associated angiogenesis promotes immune evasion, and tumor-related immune respons...

journal_title：Angiogenesis

authors： García-Martínez E,Redondo A,Piulats JM,Rodríguez A,Casado A

更新日期：2020-11-01 00:00:00

abstract：:Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogen...

journal_title：Angiogenesis

authors： Decaris ML,Lee CI,Yoder MC,Tarantal AF,Leach JK

更新日期：2009-01-01 00:00:00

abstract：:Endothelial cells are known to be a rich source of transcriptional gene expression. Recent technological advances now permit the detailed profiling of mRNA expression using arrays of known cDNAs on blots. We have used such arrays to examine expression of mRNA by primary isolates of human foreskin microvascular endothe...

journal_title：Angiogenesis

authors： Zhang HT,Gorn M,Smith K,Graham AP,Lau KK,Bicknell R

更新日期：1999-01-01 00:00:00

abstract：:Neovascularization of the inner retinal space is a major cause of vision loss. In retinal angiomatous proliferation (RAP) syndrome, newly formed vessels originate from the retinal plexus and invade the inner retinal space. However, the molecular pathways preventing subretinal vascularization remain largely unknown. In...

journal_title：Angiogenesis

authors： Niaudet C,Petkova M,Jung B,Lu S,Laviña B,Offermanns S,Brakebusch C,Betsholtz C

更新日期：2019-11-01 00:00:00