Inflammation-induced lymphangiogenesis and lymphatic dysfunction.

Abstract:

:The lymphatic system is intimately linked to tissue fluid homeostasis and immune cell trafficking. These functions are paramount in the establishment and development of an inflammatory response. In the past decade, an increasing number of reports has revealed that marked changes, such as lymphangiogenesis and lymphatic contractile dysfunction occur in both vascular and nodal parts of the lymphatic system during inflammation, as well as other disease processes. This review provides a critical update on the role of the lymphatic system in disease process such as chronic inflammation and cancer and examines the changes in lymphatic functions the diseases cause and the influence these changes have on the progression of the diseases.

journal_name

Angiogenesis

journal_title

Angiogenesis

authors

Liao S,von der Weid PY

doi

10.1007/s10456-014-9416-7

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

325-34

issue

2

eissn

0969-6970

issn

1573-7209

journal_volume

17

pub_type

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