Abstract：
:Heparan sulfate (HS), a long linear polysaccharide of alternating disaccharide residues, interacts with a wide variety of proteins, including many angiogenic factors. The involvement of HS in signaling of pro-angiogenic factors (e.g. vascular endothelial growth factor and fibroblast growth factor 2), as well as interaction with anti-angiogenic factors (e.g. endostatin), warrants its role as an important modifier of (tumor) angiogenesis. This review summarizes our current understanding of the role of HS in angiogenic growth factor signaling, and discusses therapeutic strategies to target HS and modulate angiogenesis.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
van Wijk XM,van Kuppevelt THdoi
10.1007/s10456-013-9401-6subject
Has Abstractpub_date
2014-07-01 00:00:00pages
443-62issue
3eissn
0969-6970issn
1573-7209journal_volume
17pub_type
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