Abstract:
:The plasminogen activation system has been implicated in angiogenesis and angiogenesis-dependent diseases such as cancer, atherosclerosis and ocular diseases. The identification and development of inhibitors of angiogenesis offer new possibilities for the treatment of these diseases. To clarify the role of proteins involved in the regulation of fibrinolysis during corneal angiogenesis, we have studied corneal vessel formation in mice deficient for urokinase-type plasminogen activator (uPA), tissue-type plasminogen activator (tPA), plasminogen, plasminogen activator inhibitor-1 (PAI-1) and thrombin-activatable fibrinolysis inhibitor (TAFI). Our results corroborate earlier findings that angiogenesis in the mouse cornea is dependent on PAI-1 and plasminogen. The absence of tPA, uPA or TAFI did not affect the formation of new vessels in the cornea.
journal_name
Angiogenesisjournal_title
Angiogenesisauthors
Vogten JM,Reijerkerk A,Meijers JC,Voest EE,Borel Rinkes IH,Gebbink MFdoi
10.1023/B:AGEN.0000029414.24060.fesubject
Has Abstractpub_date
2003-01-01 00:00:00pages
311-6issue
4eissn
0969-6970issn
1573-7209pii
5266537journal_volume
6pub_type
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