Procalcitonin and neopterin levels do not accurately distinguish bacterial from viral infections in ill-returned travellers with fever.

Abstract:

:The diagnostic performance of procalcitonin and neopterin as markers for bacterial and viral causes of fever was evaluated in a cohort of 69 febrile travellers with known etiological agents. Our aim was to establish a decision rule to minimize empirical antibiotic treatment. Compared with C-reactive protein (CRP) and leukocyte (differential) counts, procalcitonin and neopterin had a disappointing diagnostic accuracy. Refraining from antibiotics in case of combined presence of lymphocytosis and/or CRP ≤10 mg/l would result in an 85% reduction in unwanted antibiotic treatment in patients with viral disease but in adequate antibiotic coverage of all patients with bacterial disease.

authors

te Witt R,Hassing RJ,Petit PP,van Belkum A,van Genderen PJ

doi

10.1016/j.trstmh.2012.01.001

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

264-6

issue

4

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(12)00002-8

journal_volume

106

pub_type

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