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The relationship between the in vitro response of Plasmodium falciparum to chloroquine, quinine and mefloquine.

Abstract：

:We have measured the in vitro response of several isolates of Plasmodium falciparum to chloroquine, quinine and mefloquine. We show that parasites which are resistant to chloroquine also have a reduced sensitivity to quinine. However, there appears to be no correlation between chloroquine resistance and reduced sensitivity to mefloquine. We conclude that the emergence and spread of chloroquine resistance could also be establishing a population of parasites with a reduced sensitivity to quinine which may provide the basis for the eventual emergence of quinine resistance.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Knowles G,Davidson WL,Jolley D,Alpers MP

doi

10.1016/0035-9203(84)90260-8

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

146-50

issue

2

eissn

0035-9203

issn

1878-3503

journal_volume

78

pub_type

杂志文章

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