Cost-effectiveness analysis of diagnostic tests for human visceral leishmaniasis in Brazil.

Abstract:

BACKGROUND:The objective of study was to estimate the incremental cost-effectiveness ratio (ICER) of diagnostic options for visceral leishmaniasis (VL) in Brazil. METHODS:Six diagnostic tests were considered: IT LEISH, Kalazar Detect, DAT-LPC (DAT made in the Laboratório de Pesquisas Clínicas), IFAT, PCR and direct examination of bone marrow aspirate performed in either an ambulatory or a hospital setting. A database was built using the cost and effectiveness. The perspective of this study was the Brazilian public healthcare system and the results were expressed in costs per correctly diagnosed cases. RESULTS:In a favorable hypothetical scenario, DAT-LPC presented the lowest cost (US$4.92) and highest effectiveness (99%). Paired analyses showed that IT LEISH was dominant compared to IFAT, microscopy and Kalazar Detect and that Kalazar Detect was dominant over IFAT and microscopy. PCR was dominant over the bone marrow aspirate in the hospital and showed an ICER of 57.76 compared with aspirate in an ambulatory setting. CONCLUSIONS:These results highlight the need for the revision of algorithm for VL diagnostic in Brazil. Replacements of IFAT with DAT-LPC, Kalazar Detect with IT LEISH and bone marrow aspirate performed in a hospital setting with PCR are cost-effective public health measures.

authors

Machado de Assis TS,Azeredo-da-Silva AL,Werneck GL,Rabello A

doi

10.1093/trstmh/trw050

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

464-71

issue

8

eissn

0035-9203

issn

1878-3503

pii

trw050

journal_volume

110

pub_type

杂志文章
  • Alternative measures of diarrhoeal morbidity and their association with social and environmental factors in urban children in The Gambia.

    abstract::Diarrhoeal morbidity was studied during a 15-week period of the rainy season in 244 children aged 6 to 35 months in an urban Gambian community. The average prevalence of diarrhoea was 12.0% and the mean number of episodes per child varied between 2.4 and 2.9 depending on the definition of an episode. The number of chr...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90052-6

    authors: Pickering H,Hayes RJ,Tomkins AM,Carson D,Dunn DT

    更新日期:1987-01-01 00:00:00

  • Molecular mechanisms associated with quinolone resistance in Enterobacteriaceae: review and update.

    abstract:BACKGROUND:Quinolones are broad-spectrum antibiotics, which are used for the treatment of different infectious diseases associated with Enterobacteriaceae. During recent decades, the wide use as well as overuse of quinolones against diverse infections has led to the emergence of quinolone-resistant bacterial strains. H...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/traa041

    authors: Azargun R,Gholizadeh P,Sadeghi V,Hosainzadegan H,Tarhriz V,Memar MY,Pormohammad A,Eyvazi S

    更新日期:2020-10-05 00:00:00

  • Comparative efficacy of alternative primary therapies for Plasmodium falciparum infections in Malawi.

    abstract::In Malawi, where high levels of chloroquine resistance were shown using a modified 7-day in vivo test, amodiaquine and pyrimethamine-sulfadoxine were evaluated as alternative initial therapies for Plasmodium falciparum infections in children under 5 years old. Therapy success rates, judged by parasite clearance by day...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90005-8

    authors: Heymann DL,Khoromana CO,Wirima JJ,Campbell CC

    更新日期:1987-01-01 00:00:00

  • Rabies serum neutralizing antibody in mongooses from Grenada.

    abstract::During a four-year study on Grenada, 4,754 mongooses were examined, of which 100 (2.1%) were rabid. Of 1,675 mongooses tested for rabies serum neutralizing (SN) antibody, 498 (30%) were positive. During these four years (1971-74) the antibody prevalence rate increased from 20.8% to 43.2%, whereas the number of rabid m...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(81)90143-7

    authors: Everard CO,Baer GM,Alls ME,Moore SA

    更新日期:1981-01-01 00:00:00

  • Predictable ecology and geography of avian influenza (H5N1) transmission in Nigeria and West Africa.

    abstract::The emerging virus strain termed highly pathogenic H5N1 avian influenza (HP-H5N1) has spread widely in the past decade and is now the focus of considerable concern in several sectors. We tested the hypothesis that spatial distributions of veterinary and human HP-H5N1 cases are related to coarse-scale environmental fea...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.01.016

    authors: Williams RA,Fasina FO,Peterson AT

    更新日期:2008-05-01 00:00:00

  • A prospective study on the dynamics of the clinical and immunological evolution of human Leishmania (L.) infantum chagasi infection in the Brazilian Amazon region.

    abstract::This prospective study was carried out from October 2003 to December 2005 and involved a cohort of 946 individuals of both genders, aged 1-89 years, from an endemic area for American visceral leishmaniasis (AVL), in Pará State, Brazil. The aim of the study was to analyze the dynamics of the clinical and immunological ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2010.05.002

    authors: Silveira FT,Lainson R,Crescente JA,de Souza AA,Campos MB,Gomes CM,Laurenti MD,Corbett CE

    更新日期:2010-08-01 00:00:00

  • Efficacy of artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of uncomplicated malaria among children in Rwanda: an open-label, randomized controlled trial.

    abstract:BACKGROUND:Artemisinin-based combination therapies (ACTs) have proven highly effective in reducing malaria morbidity in sub-Saharan Africa. Artemether-lumefantrine (AL) was introduced in 2005 as a first-line ACT for the treatment of uncomplicated malaria in Rwanda. Monitoring the therapeutic efficacy of ACTs is necessa...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/trstmh/trz009

    authors: Uwimana A,Penkunas MJ,Nisingizwe MP,Warsame M,Umulisa N,Uyizeye D,Musanabaganwa C,Munyaneza T,Ntagwabira E,Hakizimana D,Muvunyi CM,Kayobotsi C,Kabera M,Murindahabi M,Mbituyumuremyi A

    更新日期:2019-06-01 00:00:00

  • DNA thermodynamic pressure: a potential contributor to genome evolution.

    abstract::Codon usage bias is a feature of living organisms. The origin of this bias might be explained not only by external factors but also by the nature of the structure of deoxyribonucleic acid (DNA) itself. We have developed a point mutation simulation program of coding sequences, in which nucleotide replacement follows th...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(02)90046-5

    authors: Zimic MJ,Guerra D,Arévalo J

    更新日期:2002-04-01 00:00:00

  • Identification of Naegleria fowleri in fresh isolates of environmental amoebae using a staphylococcal coagglutination technique.

    abstract::A coagglutination test using Staphylococcus aureus Cowan strain 1 sensitized with specific antiserum successfully identified Naegleria fowleri in axenic and monoxenic culture by detection of a heat stable antigen released into the culture medium during growth. Strong coagglutination, visible to the naked eye, occurred...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(86)90141-0

    authors: Kilvington S,White DG

    更新日期:1986-01-01 00:00:00

  • Bites by Russell's vipers (Daboia russelii siamensis) in Myanmar: effect of the snake's length and recent feeding on venom antigenaemia and severity of envenoming.

    abstract::An improved enzyme immunoassay technique (EIA) was used in the diagnosis of 311 suspected Russell's viper bite cases in Myanmar [Burma], 181 of whom (58%) had systemic envenoming. Russell's viper venom was detected in the sera of 175 (56.3%), cobra or green pit viper venoms in 4 (1.3%), and no venom in the remaining 1...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(91)90464-a

    authors: Tun-Pe,Ba-Aye,Aye-Aye-Myint,Tin-Nu-Swe,Warrell DA

    更新日期:1991-11-01 00:00:00

  • Chloroquine resistant Plasmodium falciparum on the island of Flores, Indonesia.

    abstract::The in vitro sensitivity of Plasmodium falciparum to chloroquine was studied in parasites from 45 children on the island of Flores, Indonesia. The micro in vitro culture technique and a 12-volt battery-operated field incubator were found to be well suited to the field situation encountered. Parasites from seven childr...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(83)90112-8

    authors: Smrkovski LL,Hoffman SL,Purnomo,Hussein RP,Masbar S,Kurniawan L

    更新日期:1983-01-01 00:00:00

  • Clinical evaluation of a new anthelmintic - C. 9333 Go./CGP 4540 in human hookworm infection.

    abstract::A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. T...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章

    doi:10.1016/0035-9203(77)90017-7

    authors: Vakil BJ,Dalal NJ,Shah PN

    更新日期:1977-01-01 00:00:00

  • Isoenzyme characterization of 112 Leishmania isolates from French Guiana.

    abstract::112 Leishmania isolates, obtained in French Guiana from human lesions, phlebotomine sandflies and wild mammals, were characterized by isoenzyme electrophoresis. Leishmania braziliensis guyanensis and L. mexicana amazonensis were found parasitizing different natural hosts. L.b. guyanensis was the dominant species (103 ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(89)90373-8

    authors: Desjeux P,Dedet JP

    更新日期:1989-09-01 00:00:00

  • Data safety and monitoring boards for African clinical trials.

    abstract::The recent increase in funding for diseases endemic in resource-poor countries has led to a progressive rise in the number of trials conducted in Africa for product development purposes or to answer important questions on reduction of disease burden. This causes an increasing demand for data safety monitoring boards (...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.06.009

    authors: Lang T,Chilengi R,Noor RA,Ogutu B,Todd JE,Kilama WL,Targett GA

    更新日期:2008-12-01 00:00:00

  • Seroreversion in children born to HIV-positive and AIDS mothers from Central West Brazil.

    abstract::The spread of HIV-1 infection among women of childbearing age has led to increasing numbers of children at risk of vertical transmission. This study aimed to assess child outcomes among HIV-positive (n=19) and AIDS (n=22) mothers from Central West Brazil. CD4(+) T-cell counts (FACScount, BD) and viral loads (HIV-1 RT-...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.trstmh.2009.03.016

    authors: Alcântara KC,Pereira GA,Albuquerque M,Stefani MM

    更新日期:2009-06-01 00:00:00

  • Visceral leishmaniasis: use of the polymerase chain reaction in an epidemiological study in Baringo District, Kenya.

    abstract::The polymerase chain reaction was applied to capillary blood spots dried on filter paper from 20 parasitologically proved cases of visceral leishmaniasis (VL), 21 subclinical cases, and 11 healthy controls in a longitudinal study of anthroponotic VL in Baringo District, Kenya. Leishmania deoxyribonucleic acid (DNA) wa...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90081-0

    authors: Schaefer KU,Schoone GJ,Gachihi GS,Muller AS,Kager PA,Meredith SE

    更新日期:1995-09-01 00:00:00

  • Hyperpigmented dermal macules in children following the administration of Maloprim for malaria chemoprophylaxis.

    abstract::The occurrence of an unexpected side effect following the use of Maloprim (pyrimethamine/dapsone) for malaria chemosuppression in 3-59 months old children in Sierra Leone is reported. As part of a trial of chemoprophylaxis and insecticide-impregnated bed nets, 2000 children received either Maloprim or placebo; 4% of c...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0035-9203(97)90225-x

    authors: David KP,Marbiah NT,Lovgren P,Greenwood BM,Petersen E

    更新日期:1997-03-01 00:00:00

  • High tuberculosis incidence among people living with diabetes in Indonesia.

    abstract:BACKGROUND:Data regarding the incidence of tuberculosis (TB) among people living with diabetes (PLWD) in TB-endemic settings are scarce. We examined TB incidence among PLWD in Indonesia who had previously been screened for latent TB infection (LTBI) and TB disease. METHODS:PLWD (≥18 y of age) in an urban setting were ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trz100

    authors: McAllister SM,Koesoemadinata RC,Santoso P,Soetedjo NNM,Kamil A,Permana H,Ruslami R,Critchley JA,van Crevel R,Hill PC,Alisjahbana B

    更新日期:2020-02-07 00:00:00

  • Population biology of hookworms in west Bengal: analysis of numbers of infective larvae recovered from damp pads applied to the soil surface at defaecation sites.

    abstract::The aims of this study were to analyze the seasonal distribution of infective larvae on the soil surface, to determine whether numbers of infective larvae near faeces were related to the faecal egg count of individuals, and to relate the distribution of larvae to environmental characteristics. Larvae were recovered fr...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90371-3

    authors: Hominick WM,Dean CG,Schad GA

    更新日期:1987-01-01 00:00:00

  • Sampling and storage of blood and the detection of malaria parasites by polymerase chain reaction.

    abstract::Polymerase chain reaction (PCR) is now widely used in malaria research for analysis of field samples. However, little has been reported regarding loss of sensitivity due to field methodology. Therefore, studies were carried out in relation to blood sampling (anticoagulants, culture medium, filter paper), storage (temp...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s0035-9203(99)90177-3

    authors: Färnert A,Arez AP,Correia AT,Björkman A,Snounou G,do Rosário V

    更新日期:1999-01-01 00:00:00

  • Prevalence of drug resistant TB among outpatients at an HIV/TB clinic in Lilongwe, Malawi.

    abstract:BACKGROUND:We sought to determine the prevalence of drug resistant TB among outpatients initiating TB treatment in Lilongwe, Malawi. METHODS:This was a prospective cohort study of patients 18 years and older initiating TB treatment at Martin Preuss Centre, the primary integrated HIV/TB clinic in Lilongwe, Malawi, from...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trv092

    authors: Barnett B,Gokhale RH,Krysiak R,Kanyemba C,Chikaonda T,Bokosi M,Mukuzunga C,Saidi F,Phiri S,Hoffman IF,Hosseinipour MC

    更新日期:2015-12-01 00:00:00

  • Direct isolation in vitro of Trypanosoma brucei from man and other animals, and its potential value for the diagnosis of gambian trypanosomiasis.

    abstract::A recently described simple kit for isolating African trypanosomes in vitro (KIVI) was tested further with blood samples from man and other animals in Côte d'Ivoire and République du Congo. A high rate of success was achieved, with positive cultures being found 5-36 d after inoculation. The method was also of value in...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(92)90158-9

    authors: Truc P,Aerts D,McNamara JJ,Claes Y,Allingham R,Le Ray D,Godfrey DG

    更新日期:1992-11-01 00:00:00

  • Cross reactivity between Trypanosoma cruzi and Leishmania antigens in the lymphocyte blastogenesis assay.

    abstract::The in vitro blastogenesis response of lymphocytes from 19 patients, with either visceral or mucocutaneous leishmaniasis or Chagas disease, to antigens of the Leishmania-Trypanosoma complex was studied. Cells from all patients responded to both homologous and heterologous antigens and the magnitude of the responses di...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90291-4

    authors: Carvalho EM,Reed SG,Johnson WD Jr

    更新日期:1987-01-01 00:00:00

  • Burkholderia pseudomallei: animal models of infection.

    abstract::A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in som...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/S0035-9203(08)70026-9

    authors: Titball RW,Russell P,Cuccui J,Easton A,Haque A,Atkins T,Sarkar-Tyson M,Harley V,Wren B,Bancroft GJ

    更新日期:2008-12-01 00:00:00

  • The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children.

    abstract::Helicobacter pylori epidemiology in sub-Saharan Africa, particularly among children, has been little investigated. A secondary endpoint of our study was to examine for associations between the seroprevalence of H. pylori and the incidence of malaria. We explored H. pylori prevalence by measuring serum IgG antibodies t...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2011.09.001

    authors: Gupta V,Perez-Perez GI,Dorsey G,Rosenthal PJ,Blaser MJ

    更新日期:2012-01-01 00:00:00

  • Trypanosoma cruzi in the opossum Didelphis marsupialis: an indirect fluorescent antibody test for the diagnosis and follow-up of natural and experimental infections.

    abstract::The use of an indirect fluorescent antibody test (IFAT) performed in a "sandwich" technique has demonstrated: (i) the usefulness of the test for the diagnosis of Trypanosoma cruzi infection in the opossum Didelphis marsupialis; (ii) the existence of differences in the serological response of the opossum, that were rel...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90069-0

    authors: Jansen AM,Moriearty PL,Castro BG,Deane MP

    更新日期:1985-01-01 00:00:00

  • Dengue mortality: reassessing the risks in transition countries.

    abstract::In Singapore in 2005 there were 14,209 documented cases of dengue fever, including 25 deaths. The epidemiology of dengue in Singapore is changing, with increasingly severe infection in adults with chronic disease being recognised. We performed a retrospective review of nine adult patients who died of dengue-related il...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.06.005

    authors: Lahiri M,Fisher D,Tambyah PA

    更新日期:2008-10-01 00:00:00

  • Enzyme typing of Plasmodium falciparum from African and some other Old World countries.

    abstract::Freeze-dried and freshly cultured isolates of Plasmodium falciparum from different countries have been examined for variation in six enzymes, GPI, PGD, LDH, GDH, ADA and PEPE, using starch gel electrophoresis. Variant forms of each enzyme occur. For most enzymes, similar forms occur in isolates from different parts of...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(81)90331-x

    authors: Sanderson A,Walliker D,Molez JF

    更新日期:1981-01-01 00:00:00

  • Cutaneous and mucocutaneous leishmaniasis in Tigray, northern Ethiopia: clinical aspects and therapeutic concerns.

    abstract::Leishmaniasis is a worldwide disease, but due to the absence of surveillance systems is under-reported from low- and middle-income countries. In Ethiopia, the disease is found in the rural highlands and the incidence of Leishmania/HIV co-infection is increasing. Although some studies have been carried out in areas of ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2009.02.023

    authors: Padovese V,Terranova M,Toma L,Barnabas GA,Morrone A

    更新日期:2009-07-01 00:00:00

  • Epidemiological features of epidemic cholera (El Tor) in Zimbabwe.

    abstract::Epidemics of cholera have been frequent in southern Africa since the reintroduction of the disease to the continent in 1970. In late 1992, following a severe drought and an influx of refugees from Mozambique, cholera reappeared in Zimbabwe for the first time since 1985 and rapidly spread through the rural areas of the...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(96)90512-x

    authors: Bradley M,Shakespeare R,Ruwende A,Woolhouse ME,Mason E,Munatsi A

    更新日期:1996-07-01 00:00:00