Visceral leishmaniasis: use of the polymerase chain reaction in an epidemiological study in Baringo District, Kenya.

Abstract:

:The polymerase chain reaction was applied to capillary blood spots dried on filter paper from 20 parasitologically proved cases of visceral leishmaniasis (VL), 21 subclinical cases, and 11 healthy controls in a longitudinal study of anthroponotic VL in Baringo District, Kenya. Leishmania deoxyribonucleic acid (DNA) was detected 10.5 months before diagnosis and up to 3 years after diagnosis and apparently successful treatment. Subclinical cases can have detectable circulating parasite DNA in their blood. These findings may indicate that subclinical cases can be a reservoir and formerly treated VL patients can remain a reservoir for a long time. Xenodiagnosis should be performed on subclinical cases and former VL patients to establish their role in transmission of VL in Kenya.

authors

Schaefer KU,Schoone GJ,Gachihi GS,Muller AS,Kager PA,Meredith SE

doi

10.1016/0035-9203(95)90081-0

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

492-5

issue

5

eissn

0035-9203

issn

1878-3503

journal_volume

89

pub_type

杂志文章
  • Enteropathogenic and enterotoxigenic Escherichia coli as aetiological factors of infantile diarrhoea in rural and urban Ghana.

    abstract::There are 4 recognized classes of Escherichia coli that cause diarrhoeal disease in humans: enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC), and enterohaemorrhagic E. coli (EHEC). Preliminary analysis of enterotoxin production in a rural community in Ghana showed a prevalence of 11.0% LT-ST+, 9....

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(88)90173-3

    authors: Agbodaze D,Abrahams CA,Arai S

    更新日期:1988-01-01 00:00:00

  • Amodiaquine fails to cure chloroquine resistant Plasmodium falciparum in the Punjab.

    abstract::We evaluated amodiaquine as a replacement drug for treating falciparum malaria in an area of Pakistani Punjab where chloroquine-resistant Plasmodium falciparum has recently emerged. Amodiaquine appeared to be 4 to 8 times more effective than chloroquine when P. falciparum isolates were tested in vitro. However, the re...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90311-7

    authors: Khaliq AA,Fox E,Sarwar M,Strickland GT

    更新日期:1987-01-01 00:00:00

  • Causal prophylactic efficacy of atovaquone-proguanil (Malarone) in a human challenge model.

    abstract::Plasmodia infect the liver for about 7 days before subsequently infecting the blood. Present prophylaxis against Plasmodium falciparum malaria employs agents that primarily kill blood stages and must be continued for 28 days after the last exposure. Atovaquone-proguanil (Malarone) is a new antimalarial agent that is l...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s0035-9203(01)90206-8

    authors: Berman JD,Nielsen R,Chulay JD,Dowler M,Kain KC,Kester KE,Williams J,Whelen AC,Shmuklarsky MJ

    更新日期:2001-07-01 00:00:00

  • Oral fluoroquinolones for maintenance treatment of melioidosis.

    abstract::Ciprofloxacin (20 mg/kg/d) or ofloxacin (12 mg/kg/d) given for a median of 15 weeks (range 12-40) were used for maintenance treatment of 57 adult patients with melioidosis. The median duration of follow-up in the 45 patients who complied with treatment and were followed for at least 6 months was 28 months (range 6-65)...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(97)90044-4

    authors: Chaowagul W,Suputtamongkul Y,Smith MD,White NJ

    更新日期:1997-09-01 00:00:00

  • The impact of milk and weaning diet on gastrointestinal permeability in English and Gambian infants.

    abstract::To test the hypothesis that cow's milk formula and weaning diet may damage the gut mucosa, the gastrointestinal permeability of 77 healthy English and Gambian infants was measured from the urinary recovery of the markers lactulose and mannitol included in feeds. All infants were born at term and studied at 6, 12 and 1...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(88)90236-2

    authors: Weaver LT

    更新日期:1988-01-01 00:00:00

  • Reporting notifiable diseases: methods for improvement, attitudes and community outcome.

    abstract::Notification is an important source of health information. However, it suffers from the serious limitation of under-reporting, especially in 'third world' countries. The aims of this study were to assess the impact of a special notification nurse and ward notification register on the rate of notification from a genera...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(97)90199-1

    authors: Seneviratne SL,Gunatilake SB,de Silva HJ

    更新日期:1997-03-01 00:00:00

  • Differential antibody response of Gambian donors to soluble Plasmodium falciparum antigens.

    abstract::A seroepidemiological and clinical study was performed in an area of West Africa (The Gambia) where Plasmodium falciparum is endemic with seasonal transmission. Plasma samples were tested by intermediate gel immunoelectrophoresis for antibodies against 7 soluble P. falciparum antigens. There were marked differences in...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(91)90141-k

    authors: Jakobsen PH,Riley EM,Allen SJ,Larsen SO,Bennett S,Jepsen S,Greenwood BM

    更新日期:1991-01-01 00:00:00

  • Prevalence and clinical presentation of glucose-6-phosphate dehydrogenase deficiency in Pakistani Pathan and Afghan refugee communities in Pakistan; implications for the use of primaquine in regional malaria control programmes.

    abstract::Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency surveys in Afghan refugees and a local community in the North-West Frontier Province, Pakistan, showed that this trait was most common among Pathan and Uzbak refugees (15.8% and 9.1% respectively). The prevalence among Pakistani Pathans was 7.0%, and that in Tajik ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90661-4

    authors: Bouma MJ,Goris M,Akhtar T,Khan N,Khan N,Kita E

    更新日期:1995-01-01 00:00:00

  • An outbreak of plague including cases with probable pneumonic infection, Ecuador, 1998.

    abstract::During February and March of 1998, 12 sudden deaths were reported among residents of a high-Andean community in Ecuador. All 12 fatalities were members of the same extended family and some had apparent exposure to sick guinea-pigs. Following an initial investigation by public health officials, an additional death was ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(00)90114-7

    authors: Gabastou JM,Proaño J,Vimos A,Jaramillo G,Hayes E,Gage K,Chu M,Guarner J,Zaki S,Bowers J,Guillemard C,Tamayo H,Ruiz A

    更新日期:2000-07-01 00:00:00

  • Comparison of methods for estimating drug coverage for filariasis elimination, Leogane Commune, Haiti.

    abstract::In the global effort to eliminate lymphatic filariasis, annual mass treatments are conducted with diethylcarbamazine (DEC) or ivermectin, combined with albendazole. The success of this strategy depends on achieving high levels of drug coverage, which reduces the number of persons with circulating microfilariae so that...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(03)80006-8

    authors: Mathieu E,Deming M,Lammie PJ,McLaughlin SI,Beach MJ,Deodat DJ,Addiss DG

    更新日期:2003-09-01 00:00:00

  • Nutritional status of children with schistosomiasis mansoni in two different areas of Machakos District, Kenya.

    abstract::A possible association between nutritional status and Schistosoma mansoni infection or morbidity was investigated by comparing anthropometric indices among 362 children from 3 primary schools in Machakos District, Kenya. Matithini was a prosperous school in an area (Kangundo) of moderate intensity of schistosome infec...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(92)90305-v

    authors: Corbett EL,Butterworth AE,Fulford AJ,Ouma JH,Sturrock RF

    更新日期:1992-05-01 00:00:00

  • Strongyloidiasis in a high risk community of Dhaka, Bangladesh.

    abstract::Residents of a slum community of Dhaka city, Bangladesh were tested by serological and faecal examination for evidence of Strongyloides stercoralis infection. In stool specimens from a total of 147 participants Strongyloides larvae were found in 34 (23.1%) by Harada-Mori culture, 15 (10.2%) by agar plate culture (APC)...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2012.08.011

    authors: Sultana Y,Gilbert GL,Ahmed BN,Lee R

    更新日期:2012-12-01 00:00:00

  • Clinical evaluation of a new anthelmintic - C. 9333 Go./CGP 4540 in human hookworm infection.

    abstract::A new antihookworm compound, C.9333 Go./CGP 4540, was evaluated clinically in 65 adult patients with hookworm infection. Several dosage schedules were evaluated to determine an effective, well tolerated and convenient regime. The lowest effective dose was 125 mg administered at four-hourly intervals for three doses. T...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章

    doi:10.1016/0035-9203(77)90017-7

    authors: Vakil BJ,Dalal NJ,Shah PN

    更新日期:1977-01-01 00:00:00

  • The efficacy of antivenom in the treatment of bites by the Papuan taipan (Oxyuranus scutellatus canni).

    abstract::A prospective series of 156 patients systemically envenomed following the bite of a Papuan taipan (Oxyuranus scutellatus canni) were studied. All patients were treated with appropriate antivenom and clinical course and outcome were compared. The proportion of patients requiring intubation was significantly smaller, an...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90562-6

    authors: Trevett AJ,Lalloo DG,Nwokolo NC,Naraqi S,Kevau IH,Theakston RD,Warrell DA

    更新日期:1995-05-01 00:00:00

  • Schistosomiasis prophylaxis in vivo using N,N-diethyl-m-toluamide (DEET).

    abstract::Topical N,N-Diethyl-m-toluamide (DEET) was studied as a schistosomiasis prophylactic in vivo for the use of individuals with limited exposure. Fifteen subjects, on a 3-week expedition to Lake Malawi in September 2001, applied 50% DEET to their skin after exposure to lake water. No subjects developed evidence of a new ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0035-9203(03)90087-3

    authors: Jackson F,Doherty JF,Behrens RH

    更新日期:2003-07-01 00:00:00

  • Utilization of ultrasound in medical inpatients in Malawi.

    abstract:BACKGROUND:Ultrasound utilization studies in the developing world are important to support appropriate use. METHODS:A prospective, cross-sectional study in the medical wards at Queen Elizabeth Central Hospital, Blantyre, Malawi, was performed which aimed to assess referrals, reports and usefulness of scans to develop ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trt034

    authors: Brindle HE,Allain TJ,Kampondeni S,Kayange N,Faragher B,Bates I,Joekes E

    更新日期:2013-07-01 00:00:00

  • Chancroid in Nigeria.

    abstract::The present paper records the incidence of chancroid in northern Nigeria. Out of 776 new patients registered at the Special Treatment Clinic (STC) of the Ahmadu Bello University Teaching Hospital (ABUTH) Zaria during February to August 1982, 34 cases (4.38%) were diagnosed as chancroid. Direct smear examination for Ha...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(83)90198-0

    authors: Joshi RM,Lawande RV

    更新日期:1983-01-01 00:00:00

  • Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnel.

    abstract::On return from duty in North Solomons Province (including Bougainville Island), Papua New Guinea, 586 Australian Defence Force personnel received either primaquine (14-d) or tafenoquine (3-d) post-exposure malaria prophylaxis. Within 12 months, 6 of the 214 volunteers receiving primaquine and 7 of 378 receiving tafeno...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(02)90351-2

    authors: Nasveld P,Kitchener S,Edstein M,Rieckmann K

    更新日期:2002-11-01 00:00:00

  • Artemisinin: current status.

    abstract::The compounds derived from the Chinese medicinal plant qinghao (Artemisia annua) are the most rapidly acting of all antimalarial drugs. They are effective when given parenterally, orally or by suppository. No serious adverse effect has yet been reported in humans. The artemisinin derivatives already have an establishe...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(94)90459-6

    authors: White NJ

    更新日期:1994-06-01 00:00:00

  • The atypical lymphocyte count: a novel predictive factor for severe thrombocytopenia related to dengue.

    abstract:BACKGROUND:Early identification of patients at risk of severe dengue disease (DD) is critical to guide its management. We evaluated whether the atypical lymphocyte count (ALC), generated from the Sysmex automated full blood count analyzer, is predictive of severe thrombocytopenia secondary to Dengue infection. METHODS...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trz128

    authors: Abeysuriya V,Choong CSH,Thilakawardana BU,de Mel P,Shalindi M,de Mel C,Chandrasena L,Seneviratne SL,Yip C,Yap ES,de Mel S

    更新日期:2020-06-01 00:00:00

  • A comparative clinical trial of two different regimens of artemether plus mefloquine in multidrug resistant falciparum malaria.

    abstract::Plasmodium falciparum in Thailand is highly resistant to available antimalarial drugs. Artemether, a derivative of artemisinin, is a promising compound currently used to cope with this situation but the course of treatment has to be at least 5 d. An effective short treatment course of this drug is possible when used i...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0035-9203(95)90549-9

    authors: Karbwang J,Na-Bangchang K,Thanavibul A,Ditta-in M,Harinasuta T

    更新日期:1995-05-01 00:00:00

  • Interstitial pneumonitis in human visceral leishmaniasis.

    abstract::The involvement of the lung in 13 cases of human visceral leishmaniasis was studied. Interstitial pneumonitis with mononuclear cells was found in 76.8% of the cases; 53.8% also had foci of septal fibrosis. Leishmania were seen within macrophages in 3 cases only. However, all 10 interstitial pneumonitis cases showed PA...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(89)90712-8

    authors: Duarte MI,da Matta VL,Corbett CE,Laurenti MD,Chebabo R,Goto H

    更新日期:1989-01-01 00:00:00

  • Cerebrospinal fluid changes in tetanus: raised proteins and immunoglobulins in patients with severe disease.

    abstract::34 patients with tetanus were studied; all had normal serum proteins and albumin. Only 3 samples of cerebrospinal fluid (CSF) contained cells (a few polymorphonuclear leucocytes). Protein levels in the CSF were elevated in 26 patients (76.5%); 11 cases with clinically mild tetanus had a mean CSF protein of 400 +/- 250...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(90)90053-h

    authors: Idoko JA,Amiobonomo AE,Anjorin FI,Oyeyinka GO,Elechi C

    更新日期:1990-07-01 00:00:00

  • Studies on the leishmaniases in the Sudan. 2. Clinical and parasitological studies on cutaneous leishmaniasis.

    abstract::In the Omdurman Hospital for Tropical Diseases, Sudan, from 6 October to 1 December 1986, 736 patients with cutaneous leishmaniasis (CL) were studied. The duration of the lesions varied from a few days to 4 months, usually (56%) 1-3 months. Multiple lesions ranging from one to 50 (mean = 4) were present in 80% of case...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(91)90218-n

    authors: el-Safi SH,Peters W,el-Toam B,el-Kadarow A,Evans DA

    更新日期:1991-07-01 00:00:00

  • Accidental envenoming by a Gaboon viper (Bitis gabonica): the haemostatic disturbances observed and investigation of in vitro haemostatic properties of whole venom.

    abstract::We report the successful treatment of envenoming by the Gaboon viper (Bitis gabonica) and include results of in vitro investigations of the haemostatic properties of the whole venom. The patient was admitted to casualty soon after the bite with chest tightness, dizziness, nausea and swelling at the site of the bite an...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(93)90427-r

    authors: McNally T,Conway GS,Jackson L,Theakston RD,Marsh NA,Warrell DA,Young L,Mackie IJ,Machin SJ

    更新日期:1993-01-01 00:00:00

  • Serological and clinical investigations of human hydatid case in Libya.

    abstract::Fifty surgically confirmed cases of hydatid disease in Eastern Libya were investigated. Of these, 30 had cysts of the liver, five had extra-hepatic abdominal cysts and 15 had cysts in the chest, including the lungs. Ten cases of malignancy of the liver and five cases of malignancy of the lung were used as controls. Di...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(78)90121-9

    authors: Taguri S,Dar FK

    更新日期:1978-01-01 00:00:00

  • Growth and diarrhoeal disease surveillance in a rural Ghanaian pre-school child population.

    abstract::This paper is a report of the first year of follow-up on 250 pre-school children in a village in Ghana. The mean weight for age and the mean height for age at the start of the study, ranged between 81 and 97% and 91 and 101.4% of the median WHO reference standards respectively. Classified according to Waterlow (1973) ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(86)90012-x

    authors: Biritwum RB,Isomura S,Assoku A,Torigoe S

    更新日期:1986-01-01 00:00:00

  • The relationship between anaemia and malaria: apparently simple, yet controversial.

    abstract::Among many other factors, malaria plays a major causative role of anaemia globally. The mechanisms leading to anaemia in the course of malaria are extremely diverse, involving immunological factors that act differently according to age and malaria epidemiology. The malaria-attributable fraction of anaemia may then dif...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/tru012

    authors: Castelli F,Sulis G,Caligaris S

    更新日期:2014-04-01 00:00:00

  • The Pseudomonas aeruginosa product pyochelin interferes with Trypanosoma cruzi infection and multiplication in vitro.

    abstract:BACKGROUND:Bacteria are sources of numerous molecules used in treatment of infectious diseases. We investigated effects of molecules produced by 26 Pseudomonas aeruginosa strains against infection of mammalian cell cultures with Trypanosoma cruzi, the aetiological agent of Chagas disease. METHODS:Vero cells were infec...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trz136

    authors: Sass G,Miller Conrad LC,Nguyen TH,Stevens DA

    更新日期:2020-07-01 00:00:00

  • Epidemiological investigation of Taenia solium taeniasis and cysticercosis in a rural village of Michoacan state, Mexico.

    abstract::We performed a survey for taeniasis and cysticercosis among persons living in a Mexican village where Taenia solium infection in pigs was known to be enzootic. A standardized questionnaire was administered in all 577 households to obtain medical histories and information on demographic and environmental factors and on...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(94)90493-6

    authors: Sarti E,Schantz PM,Plancarte A,Wilson M,Gutierrez OI,Aguilera J,Roberts J,Flisser A

    更新日期:1994-01-01 00:00:00