Abstract:
:In Singapore in 2005 there were 14,209 documented cases of dengue fever, including 25 deaths. The epidemiology of dengue in Singapore is changing, with increasingly severe infection in adults with chronic disease being recognised. We performed a retrospective review of nine adult patients who died of dengue-related illness from 1 December 2004 to 30 November 2005 at the National University Hospital. The diagnosis was initially missed in six of the nine patients due to an atypical presentation. All the patients had significant comorbid conditions; six of the nine had diabetes mellitus. Altered mental state preceded frank shock in eight of the nine patients. Secondary bacteraemia was a contributor to death in four. Derangement of laboratory features such as prothrombin time, activated partial thromboplastin time and serum albumin level was common on presentation. Transition countries such as Singapore have an increasingly advanced health system supporting an ageing population, yet are still at risk of community-acquired tropical infections. We have found that atypical presentations, comorbidities, secondary bacterial infection and abnormal serum markers at presentation may be predictors of death from dengue.
journal_name
Trans R Soc Trop Med Hygauthors
Lahiri M,Fisher D,Tambyah PAdoi
10.1016/j.trstmh.2008.06.005subject
Has Abstractpub_date
2008-10-01 00:00:00pages
1011-6issue
10eissn
0035-9203issn
1878-3503pii
S0035-9203(08)00266-6journal_volume
102pub_type
杂志文章abstract::A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in som...
journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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更新日期:1998-09-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:1981-01-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,评审
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.trstmh.2003.12.004
更新日期:2004-07-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-06-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:2008-03-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,评审
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更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,评审
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更新日期:1993-09-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
doi:10.1016/j.trstmh.2012.08.005
更新日期:2012-12-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
doi:10.1016/j.trstmh.2008.01.002
更新日期:2008-04-01 00:00:00
abstract::In a region of Sudanese savannah in Burkina Faso, insecticide-treated curtains were installed in 8 out of 16 zones, each covering an area of about 50 km2. Longitudinal entomological monitoring using CDC light traps was performed in 4 villages (2 intervention, 2 control) over a period of 3 years (including 1 year prior...
journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-09-01 00:00:00