Abstract:
:In 1991, a study on Wuchereria bancrofti microfilariae (mf) and infection rates was carried out in the human and mosquito populations of a Polynesian village where, 10 years before, the mf prevalence rate was 6.4% and twice-yearly mass treatment with 3 mg/kg of diethylcarbamazine (DEC) was interrupted. Venous blood samples were collected from 575 (97%) individuals aged 15 years or more, of whom 122 (21.4%) were mf positive. The mf carrier prevalence rate was 27.4% in males, significantly higher than that of 14% in females; it increased from 7-12% in the youngest age group (15-19 years) to 40-50% in the oldest (> or = 60 years) for both males and females. 387 mosquito collections were performed and 1748 female Aedes polynesiensis were dissected, of which 1176 were parous. Among the latter, 114 (9.7%) were infected with Wuchereria bancrofti larvae at L1, L2 or L3 stages. The mean number of larvae per mosquito was 2.46 (range 1-15). Of the 114 infected mosquitoes, 30 harboured L3 larvae, giving a 2.55% infective rate; the mean number of L3 larvae per mosquito was 1.15 (range 1-2). Such findings indicate that the interruption of systematic twice-yearly mass treatment with DEC (3 mg/kg) has resulted, after 10 years, in a substantial increase of microfilarial prevalence in humans, and in high infection rates in mosquitoes.
journal_name
Trans R Soc Trop Med Hygauthors
Cartel JL,Nguyen NL,Spiegel A,Moulia-Pelat JP,Plichart R,Martin PM,Manuellan AB,Lardeux Fdoi
10.1016/0035-9203(92)90245-8subject
Has Abstractpub_date
1992-07-01 00:00:00pages
414-6issue
4eissn
0035-9203issn
1878-3503journal_volume
86pub_type
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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更新日期:2010-07-01 00:00:00