Highly pyrimethamine-resistant alleles of dihydrofolate reductase in isolates of Plasmodium falciparum from Tanzania.

abstract：:Antibiotic resistance on account of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-PE) has become a major public health concern in developing countries. The presence of ESBL-PE is associated with increased morbidity, mortality and healthcare costs. There is no active antimicrobial surveillance mechan...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Musa BM,Imam H,Lendel A,Abdulkadir I,Gumi HS,Aliyu MH,Habib AG

更新日期：2020-04-08 00:00:00

abstract：:The sickle cell gene was first described in India in a tribal population in the south, leading to the belief that it was confined to tribal groups. The present study confirms that it is widespread in the state of Orissa and spreads throughout Hindu society, being more common in upper and scheduled castes than in triba...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Kar BC,Devi S,Dash KC,Das M

更新日期：1987-01-01 00:00:00

abstract：:Tinea imbricata, also known as 'Tokelau', is an uncommon superficial mycosis caused by the anthropophilic dermatophyte Trichophyton concentricum. Cutaneous lesions appear characteristically as scaly and concentric rings that may cover all parts of the body. Often acquired in childhood, tinea imbricata is a chronic dis...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Pihet M,Bourgeois H,Mazière JY,Berlioz-Arthaud A,Bouchara JP,Chabasse D

更新日期：2008-04-01 00:00:00

abstract：:Infections with Mansonella perstans are common in certain parts of Africa and South America. There is no standard treatment at present. We evaluated the effect of a single high dose of ivermectin (600 micrograms/kg) on microfilaraemia in 7 consecutive patients. No decrease in microfilarial counts could be demonstrated...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Van den Enden E,Van Gompel A,Van der Stuyft P,Vervoort T,Van den Ende J

更新日期：1993-01-01 00:00:00

abstract：:Codon usage bias is a feature of living organisms. The origin of this bias might be explained not only by external factors but also by the nature of the structure of deoxyribonucleic acid (DNA) itself. We have developed a point mutation simulation program of coding sequences, in which nucleotide replacement follows th...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Zimic MJ,Guerra D,Arévalo J

更新日期：2002-04-01 00:00:00

abstract：:A semi-automated cultivation apparatus for the in vitro culture of Plasmodium falciparum gametocytes is described. This apparatus has been designed to produce large numbers of fertile sexual stages for use in the development of a gamete vaccine or for the infection of suitable mosquitoes. These mosquitoes in turn may ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ponnudurai T,Lensen AH,Leeuwenberg AD,Meuwissen JH

更新日期：1982-01-01 00:00:00

abstract：:A fibroblast-like cell line derived from the mountain vole Microtus montanus was effective in promoting an increase in the multiplication rate of new and established isolates of Plasmodium falciparum. An increase in multiplication rate was also achieved in the absence of M. montanus cells when cultures of P. falciparu...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Trenholme KR,McMonagle FA,Phillips RS

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:We sought to determine the prevalence of drug resistant TB among outpatients initiating TB treatment in Lilongwe, Malawi. METHODS:This was a prospective cohort study of patients 18 years and older initiating TB treatment at Martin Preuss Centre, the primary integrated HIV/TB clinic in Lilongwe, Malawi, from...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Barnett B,Gokhale RH,Krysiak R,Kanyemba C,Chikaonda T,Bokosi M,Mukuzunga C,Saidi F,Phiri S,Hoffman IF,Hosseinipour MC

更新日期：2015-12-01 00:00:00

abstract：:Lassa fever convalescent plasma (LFCP) has been administered to 27 patients in hospitals at Jos and Vom, Nigeria. Among serologically or virologically confirmed cases of Lassa fever (LF) given plasma on or before the 10th day, all eight survived, as did two of three possible LF cases. Of eight patients given LFCP afte...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Frame JD,Verbrugge GP,Gill RG,Pinneo L

更新日期：1984-01-01 00:00:00

abstract：:Schistosomiasis among pregnant women has been inadequately investigated. In order to determine the importance of Schistosoma mansoni in this subgroup, we conducted a cross-sectional survey of 972 women in Tanzania and investigated the prevalence of Schistosoma mansoni, hookworm and malaria and their associations with ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ajanga A,Lwambo NJ,Blair L,Nyandindi U,Fenwick A,Brooker S

更新日期：2006-01-01 00:00:00

abstract：:During a five-year period, 45 Nigerians with radiographic appearances of diffuse pulmonary infiltration with at least six sputum specimens negative on culture for tubercule bacilli were investigated at University College Hospital, Ibadan. The value of pulmonary function studies and open or closed lung biopsy in discov...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Onadeko BO,Sofowora EO,Grillo IA

更新日期：1979-01-01 00:00:00

abstract：:Using two serological techniques, eight Nigerian West Nile virus isolates were investigated to determine antigenic relationships among them, and to find out if these virus isolates were related to West Nile virus strains from the different zoogeographic areas of the world. One virus differed significantly from the sev...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Odelola HA,Fabiyi A

更新日期：1976-01-01 00:00:00

abstract：Background:Preventive chemotherapy (PC), the large-scale administration of anthelminthics, is recommended by the World Health Organization (WHO) for the control of soil-transmitted helminthiasis (STH). Since 2010, donated anthelminthics for STH have boosted the implementation of PC programmes in children, achieving glo...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Montresor A,Trouleau W,Mupfasoni D,Bangert M,Joseph SA,Mikhailov A,Fitzpatrick C

更新日期：2017-10-01 00:00:00

abstract：:alpha, beta-Arteether is an ethyl ether derivative of artemisinin which is an efficient schizontocidal drug in mild falciparum malaria. The present study reports the efficacy of the drug in severe falciparum malaria. Fifty patients with severe falciparum malaria were given intramuscular arteether, 150 mg, once daily o...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Mohanty S,Mishra SK,Satpathy SK,Dash S,Patnaik J

更新日期：1997-05-01 00:00:00

abstract：:Community treatment with ivermectin was implemented in Opoa, French Polynesia from April 1991 to October 1993. All consenting inhabitants aged 3 years or more were treated with twice-yearly single doses of ivermectin, pregnant women excepted. A dosage of 100 microgram/kg was used for the 3 first treatments and then ab...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Nguyen NL,Moulia-Pelat JP,Cartel JL

更新日期：1996-11-01 00:00:00

abstract：:The red fox is considered to be the main reservoir of the present European rabies epizootic which began in Poland in 1939-40. Its usual rate of spread is 20 to 60 km a year. Mortality among rabies-infected fox populations is estimated variously to be 20 to 60%. The infection spreads more rapidly among foxes in the aut...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Lloyd HG

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Despite the widespread use of multidrug therapy, leprosy remains an important public health concern in many regions. Detection is generally limited to clinical exam. METHODS:As a two-tiered active case finding strategy, we used the LID-1 (leprosy IDRI diagnostic-1), and PADL (protein advances for the diagno...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： de Souza MM,Netto EM,Nakatani M,Duthie MS

更新日期：2014-08-01 00:00:00

abstract：:Antibody responses were measured in a volunteer infected four times with Necator americanus over a 27-month period. The main source of antigen was culture fluid in which living adult N. americanus had been maintained for several days. Antibodies to worm acetylcholinesterase and IgE antibodies were detected only with t...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ogilvie BM,Bartlett A,Godfrey RC,Turton JA,Worms MJ,Yeates RA

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Large numbers of tuberculosis (TB) patients seek care from private for-profit providers. This study aimed to assess and compare TB control activities in the private for-profit and public sectors in Kenya between 2013 and 2017. METHODS:We conducted a retrospective cross-sectional study using routinely collec...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Mailu EW,Owiti P,Ade S,Harries AD,Manzi M,Omesa E,Kiende P,Macharia S,Mbithi I,Kamene M

更新日期：2019-12-01 00:00:00

abstract：:From the early 1900s, visceral leishmaniasis (VL; kala-azar) has been among the most important health problems in Sudan, particularly in the main endemic area in the eastern and central regions. Several major epidemics have occurred, the most recent--in Western Upper Nile province in southern Sudan, detected in 1988--...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Zijlstra EE,el-Hassan AM

更新日期：2001-04-01 00:00:00

abstract：:Response to treatment with organic pentavalent antimonials, the standard first-line treatment for visceral leishmaniasis (VL), has been decreasing since their introduction into India. Combining sodium stibogluconate (SB) with paromomycin (PM) may be an efficient alternative to single-agent therapy. This trial was desi...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Thakur CP,Kanyok TP,Pandey AK,Sinha GP,Zaniewski AE,Houlihan HH,Olliaro P

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Lymphatic filariasis (LF) is a disfiguring parasitic disease and one of the leading causes of disability in the world. This study aimed to assess the severity of lymphoedema, the physical restrictions and socio-economic impact on affected individuals living in an endemic community in Malawi. METHODS:In a si...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Martindale S,Mkwanda SZ,Smith E,Molyneux D,Stanton MC,Kelly-Hope LA

更新日期：2014-12-01 00:00:00

abstract：:34 patients with tetanus were studied; all had normal serum proteins and albumin. Only 3 samples of cerebrospinal fluid (CSF) contained cells (a few polymorphonuclear leucocytes). Protein levels in the CSF were elevated in 26 patients (76.5%); 11 cases with clinically mild tetanus had a mean CSF protein of 400 +/- 250...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Idoko JA,Amiobonomo AE,Anjorin FI,Oyeyinka GO,Elechi C

更新日期：1990-07-01 00:00:00

abstract：:The frequency, intensity and clinical features of onchocerciasis in the two ethnic groups (Blacks and Chachilla--an indigenous tribe) in the endemic foci of the disease in Esmeraldas province (Ecuador) were evaluated. The incidence of infection and intensity of the disease seen in both groups were directly related to ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Molea J,Guderian RH,Proaño R,Carrillo R,Swanson WL

更新日期：1984-01-01 00:00:00

abstract：:Three strains of Trypanosoma cruzi, used previously as prototypes for a classification based on the host-parasite relationships, as well as several stocks isolated from different geographical areas in Brazil, were submitted to isoenzymic analysis. Their isoenzyme patterns revealed a clear correlation with the biologic...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Andrade V,Brodskyn C,Andrade SG

更新日期：1983-01-01 00:00:00

abstract：:The natural host of Plasmodium knowlesi is the kra monkey, Macaca fascicularis, but this parasite, initially mistaken for P. malariae, is now infecting humans in some areas of Southeast Asia. Here we present data from experiments performed in the 1970s in which sera from a few naive M. fascicularis, taken in the cours...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Butcher GA,Mitchell GH,Cohen S

更新日期：2010-01-01 00:00:00

abstract：:ELISA AND IFAT have been applied to the sero-diagnosis of cutaneous and visceral leishmaniasis and the levels of leishmanial antibody detected by Leishmania donovani antigens in both tests have been compared. From the results it appears that ELISA is a little more sensitive than IFAT, but IFAT seems to be more specifi...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Edrissian GH,Darabian P

更新日期：1979-01-01 00:00:00

abstract：:Cultured stocks of Entamoeba hartmanni, Endolimax nana, Iodamoeba buetschlli and Dientamoeba fragilis were compared with the four Entamoeba histolytical groups already described (SARGEAUNT et al., 1978), by the electrophoretic patterns of three enzymes: glucose phosphate isomerase (GPI), phosphoglucomutase (PGM) and L...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Sargeaunt PG,Williams JE

更新日期：1979-01-01 00:00:00

abstract：:The WHO's new End TB Strategy 2016-2035 has evolved from previous global strategies to respond to old and new challenges and take advantage of new opportunities. It frames the global fight against TB as a development, social justice and human rights issue, while re-emphasizing the public health and clinical fundaments...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Lönnroth K,Raviglione M

更新日期：2016-03-01 00:00:00

abstract：:An experimental model of hepatic amoebiasis in guinea-pigs, simulating the natural infection in man, induced by progesterone following intracaecal inoculation of Entamoeba histolytica has been developed. On Day 3 after infection, 60% of the animals developed amoebic liver abscess, but on Days 7, 11, 15, 20 and 35 afte...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Gill NJ,Ganguly NK,Mahajan RC,Bhusnurmath SR,Dilawari JB

更新日期：1983-01-01 00:00:00