Antibody responses in self-infections with Necator americanus.

Abstract:

:Antibody responses were measured in a volunteer infected four times with Necator americanus over a 27-month period. The main source of antigen was culture fluid in which living adult N. americanus had been maintained for several days. Antibodies to worm acetylcholinesterase and IgE antibodies were detected only with this material, but antibodies were identified by the enzyme-linked immunosorbent (ELISA) assay, with either adult worm secretions or extracts of third-stage infective larvae. The total serum IgE level fell after the first infection, but although it then increased during subsequent infections, it never rose above 600 U per ml. None of the antibody responses suppressed the rat of worm development to maturity, or reduced the fecundity of the parasites. However, it is suggested that the development of the immune response may be associated with the waning of the severe gastro-intestinal symptoms which were experienced in this infection, and which are frequently characteristic of hookworm infections.

authors

Ogilvie BM,Bartlett A,Godfrey RC,Turton JA,Worms MJ,Yeates RA

doi

10.1016/0035-9203(78)90303-6

subject

Has Abstract

pub_date

1978-01-01 00:00:00

pages

66-71

issue

1

eissn

0035-9203

issn

1878-3503

journal_volume

72

pub_type

杂志文章
  • Wuchereria bancrofti in Tanzania: immune reactions to the microfilarial surface, and the effect of diethylcarbamazine upon these reactions.

    abstract::Immune reactions to the surface of microfilariae (mff) of Wuchereria bancrofti were investigated among persons living in an endemic filariasis area of Tanzania. The sera from a proportion of mff-negative persons contained antibodies to the microfilarial sheath, and a clear correlation was seen between presence of anti...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90137-3

    authors: Simonsen PE

    更新日期:1985-01-01 00:00:00

  • Role of water and sanitation in the incidence of cholera in refugee camps.

    abstract::The purpose of this study was to determine the prevalence of cholera in two groups: (i) people using covered latrine and piped water; (ii) people using uncovered surface latrine and pond and tubewell water. The study population consisted of cholera cases admitted to the ICDDR, B hospital from three refugee camps. In t...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(82)90194-8

    authors: Khan MU,Shahidullah M

    更新日期:1982-01-01 00:00:00

  • Pneumocystis carinii is rare in AIDS in Central Africa.

    abstract::Pneumocystis carinii occurs in 60-65% of cases of acquired immunodeficiency syndrome (AIDS) in Europe and North America. Its prevalence in Africa is unknown, however, due to a lack of suitable investigative techniques. Initial studies suggest that this parasitic complication may be lower in Africa. An investigation of...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(91)90167-w

    authors: Carme B,Mboussa J,Andzin M,Mbouni E,Mpele P,Datry A

    更新日期:1991-01-01 00:00:00

  • Direct isolation in vitro of Trypanosoma brucei from man and other animals, and its potential value for the diagnosis of gambian trypanosomiasis.

    abstract::A recently described simple kit for isolating African trypanosomes in vitro (KIVI) was tested further with blood samples from man and other animals in Côte d'Ivoire and République du Congo. A high rate of success was achieved, with positive cultures being found 5-36 d after inoculation. The method was also of value in...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(92)90158-9

    authors: Truc P,Aerts D,McNamara JJ,Claes Y,Allingham R,Le Ray D,Godfrey DG

    更新日期:1992-11-01 00:00:00

  • Entomological impact and social participation in dengue control: a cluster randomized trial in Fortaleza, Brazil.

    abstract:BACKGROUND:This study intended to implement a novel intervention strategy, in Brazil, using an ecohealth approach and analyse its effectiveness and costs in reducing Aedes aegypti vector density as well as its acceptance, feasibility and sustainability. The intervention was conducted from 2012 to 2013 in the municipali...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/trstmh/tru187

    authors: Caprara A,Lima JW,Peixoto AC,Motta CM,Nobre JM,Sommerfeld J,Kroeger A

    更新日期:2015-02-01 00:00:00

  • Population biology of hookworms in west Bengal: analysis of numbers of infective larvae recovered from damp pads applied to the soil surface at defaecation sites.

    abstract::The aims of this study were to analyze the seasonal distribution of infective larvae on the soil surface, to determine whether numbers of infective larvae near faeces were related to the faecal egg count of individuals, and to relate the distribution of larvae to environmental characteristics. Larvae were recovered fr...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(87)90371-3

    authors: Hominick WM,Dean CG,Schad GA

    更新日期:1987-01-01 00:00:00

  • Worsening of the disability grade during leprosy treatment: prevalence and its determinants in Southern Nigeria.

    abstract:Background:In Nigeria, little is known about the development of new or additional physical disability during leprosy treatment. The objective of this study was to determine the prevalence and evaluate factors associated with worsening of physical disability during leprosy treatment in Nigeria. Methods:This was a retro...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,多中心研究

    doi:10.1093/trstmh/try085

    authors: Chukwu JN,Ekeke N,Nwafor CC,Meka AO,Alphonsus C,Mbah OK,Eze CC,Ukwaja KN

    更新日期:2018-11-01 00:00:00

  • Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication.

    abstract::Cerebral gnathostomiasis is a severe form of human infection caused by Gnathostoma spinigerum. We report sequential brain imaging in serologically proven cerebral gnathostomiasis. The clinical and radiographic correlation showed the probable route taken by the parasite during its migration through the central nervous ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.09.011

    authors: Sawanyawisuth K,Chlebicki MP,Pratt E,Kanpittaya J,Intapan PM

    更新日期:2009-01-01 00:00:00

  • Amino-acid and glucose utilization of Leishmania donovani and L. braziliensis.

    abstract::The availability of a defined medium (STEIGER & STEIGER, 1976) has enabled studies on the nutritional requirements of promastigotes of L. donovani and L. braziliensis (STEIGER & STEIGER, 1977). As outlined elsewhere (STEIGER & MESHNICK, 1977), the present paper describes preliminary experiments dealing with the utiliz...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(77)90049-9

    authors: Steiger RF,Meshnick SR

    更新日期:1977-01-01 00:00:00

  • Leishmania (Viannia) lainsoni occupies a unique niche within the subgenus Viannia.

    abstract::Leishmania lainsoni has recently been recognized as a new peripylarian species belonging to the subgenus Viannia and the L. braziliensis complex. It has been isolated from its sandfly vector, reservoir host and cutaneous lesions of human patients. Microscopical examination has shown characteristics which are different...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90509-x

    authors: Eresh S,de Bruijn MH,Mendoza-León JA,Barker DC

    更新日期:1995-03-01 00:00:00

  • What's in a name? Ulcerans disease: infections due to Mycobacterium ulcerans.

    abstract::Lesions due to Mycobacterium ulcerans infection may have more synonyms and eponyms than any other disease. New diseases are named for the person who discovered them, from the place from which they were first described or some major clinical feature. 'Buruli ulcer', the name by which the disease is most frequently know...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 评论,杂志文章,评审

    doi:10.1016/j.trstmh.2008.12.009

    authors: Radford AJ

    更新日期:2009-10-01 00:00:00

  • Altered uptake of metronidazole in vitro by stocks of Giardia intestinalis with different drug sensitivities.

    abstract::Growth of Giardia intestinalis in TYI-S-33 medium containing a sub-lethal concentration of metronidazole over a period of 66 weeks selected a line of organisms that was over 8 times less sensitive to the drug. This resistance was unstable and the organisms reverted to their original sensitivity within 22 weeks of grow...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(88)90278-7

    authors: Boreham PF,Phillips RE,Shepherd RW

    更新日期:1988-01-01 00:00:00

  • Application of the avidin-biotin immunohistochemical method for the diagnosis of alveolar hydatid disease from tissue sections.

    abstract::The avidin-biotin immunohistochemical (ABC) method was applied to the diagnosis of alveolar hydatid disease in patients from the hyperendemic region of western Alaska. The test was specific for larval cestodes of the genus Echinococcus, and exhibited high sensitivity. A negative reaction was obtained in all cases in w...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(88)90219-2

    authors: Condon J,Rausch RL,Wilson JF

    更新日期:1988-01-01 00:00:00

  • Visceral leishmaniasis: use of the polymerase chain reaction in an epidemiological study in Baringo District, Kenya.

    abstract::The polymerase chain reaction was applied to capillary blood spots dried on filter paper from 20 parasitologically proved cases of visceral leishmaniasis (VL), 21 subclinical cases, and 11 healthy controls in a longitudinal study of anthroponotic VL in Baringo District, Kenya. Leishmania deoxyribonucleic acid (DNA) wa...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(95)90081-0

    authors: Schaefer KU,Schoone GJ,Gachihi GS,Muller AS,Kager PA,Meredith SE

    更新日期:1995-09-01 00:00:00

  • A successful outcome of gross haematuria treated with diethylcarbamazine and ivermectin.

    abstract::Gross haematuria caused by lymphatic filariasis has been rarely reported. An adult woman living in a filarial-endemic area presented at a hospital in Orissa, India, in July 2004, with painless gross haematuria without any associated symptoms, such as dysuria, abdominal pain and fever. Urine microscopy revealed many er...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.02.008

    authors: Kerketta AS,Dhal K,Nayak R

    更新日期:2008-05-01 00:00:00

  • Anaemia caused by asymptomatic Plasmodium falciparum infection in semi-immune African schoolchildren.

    abstract::A cohort of 250 Ghanaian schoolchildren aged 5-15 years was followed clinically and parasitologically for 4 months in 1997/98 in order to study the effect of asymptomatic Plasmodium falciparum infections on haematological indices and bone-marrow responses. Of the 250 children 65 met the predefined study criteria. Thus...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(99)90073-1

    authors: Kurtzhals JA,Addae MM,Akanmori BD,Dunyo S,Koram KA,Appawu MA,Nkrumah FK,Hviid L

    更新日期:1999-11-01 00:00:00

  • Anti-leishmanial effect of allopurinol ribonucleoside and the related compounds, allopurinol, thiopurinol, thiopurinol ribonucleoside, and of formycin B, sinefungin and the lepidine WR6026.

    abstract::Allopurinol and allopurinol ribonucleoside tested in vitro and in vivo for activity against Leishmania donovani. Activity in vitro was low against the amastigote form of this parasite with ED50 values of the order of 54 and 96 microM and 86 and 213 microM respectively for the two compounds. In vivo inhibition of up to...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90255-x

    authors: Neal RA,Croft SL,Nelson DJ

    更新日期:1985-01-01 00:00:00

  • Are health education interventions effective for the control and prevention of urogenital schistosomiasis in sub-Saharan Africa? A systematic review.

    abstract::An estimated 129 million people are infected with urogenital schistosomiasis in sub-Saharan Africa. Current control recommendations endorse mass administration of praziquantel. Health education is an important component of effective schistosomiasis prevention and control, but there has been limited research on its eff...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,评审

    doi:10.1093/trstmh/trv008

    authors: Price A,Verma A,Welfare W

    更新日期:2015-04-01 00:00:00

  • Public health importance of non-biting cyclorrhaphan flies.

    abstract::This study was carried out to determine the role of non-biting cyclorrhaphan flies as carriers of human intestinal parasites at Woreta, northwestern Ethiopia. In total, 6530 flies were collected from four breeding sites and then examined for human intestinal parasites, mainly using the formol-ether concentration metho...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2008.08.010

    authors: Fetene T,Worku N

    更新日期:2009-02-01 00:00:00

  • Antibody and cellular immune responses to Plasmodium falciparum histidine-rich protein II in malaria-exposed individuals in Orissa, India.

    abstract::The precise function of Plasmodium falciparum histidine-rich protein II (HRPII) is not known, but in vitro studies have indicated its immunomodulatory function. The host immune response to HRPII was measured and compared with the response to P. falciparum merozoite surface protein 1 (MSP1) in four groups of study subj...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/j.trstmh.2010.01.002

    authors: Das P,Grewal JS,Chauhan VS

    更新日期:2010-05-01 00:00:00

  • Kinetics of lymphocyte subpopulations and their functions in cases of amoebic liver abscess.

    abstract::This study shows the relationship between lymphocyte subpopulations and their response to non-specific stimulant phytohaemagglutinin (PHA) and specific stimulant (amoebic antigen) in cases of amoebic liver abscess in relation to the duration of disease, based on the first appearance of symptoms and/or signs, 26 patien...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(81)90417-x

    authors: Ganguly NK,Mahajan RC,Gill NJ,Koshy A

    更新日期:1981-01-01 00:00:00

  • The lymphatic pathology of chronic Brugia pahangi infection in the dog.

    abstract::The dog infected with Brugia pahangi is an excellent model for studying the clinical and immunological pathogenesis of lymphatic filarial infection and disease. Dogs demonstrated a range of clinical changes including varying levels of microfilaraemia, episodic lymphadenopathy, lymphangitis, and limb oedema similar to ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(89)90394-5

    authors: Snowden KF,Hammerberg B

    更新日期:1989-09-01 00:00:00

  • A comparison of enzyme-linked immunosorbent assay and indirect fluorescent antibody test in the sero-diagnosis of cutaneous and visceral leishmaniasis in Iran.

    abstract::ELISA AND IFAT have been applied to the sero-diagnosis of cutaneous and visceral leishmaniasis and the levels of leishmanial antibody detected by Leishmania donovani antigens in both tests have been compared. From the results it appears that ELISA is a little more sensitive than IFAT, but IFAT seems to be more specifi...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(79)90084-1

    authors: Edrissian GH,Darabian P

    更新日期:1979-01-01 00:00:00

  • Levels of circulating soluble egg antigen in urine of individuals infected with Schistosoma mansoni before and after treatment with praziquantel.

    abstract::We used a recently developed sandwich enzyme-linked immunosorbent assay to determine the kinetics of Schistosoma mansoni circulating soluble egg antigen (CSEA) after chemotherapy and compared these with previously determined levels of circulating cathodic antigen (CCA). Urine samples were collected from 35 Egyptian pa...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/s0035-9203(98)90809-4

    authors: Nibbeling HA,Van Lieshout L,Deelder AM

    更新日期:1998-11-01 00:00:00

  • Influence of Toxoplasma on manifestations of Moloney virus infections.

    abstract::Considerable evidence documents the importance of co-factors, including the immune response, in expression of oncogenicity of tumour viruses. To determine whether a common protozoal infection that can depress lymphocyte function alters manifestations of oncogenic virus infection, a mouse model of Toxoplasma infection ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90116-6

    authors: McLeod R,Estes RG,Cohen H

    更新日期:1985-01-01 00:00:00

  • Interstitial pneumonitis in human visceral leishmaniasis.

    abstract::The involvement of the lung in 13 cases of human visceral leishmaniasis was studied. Interstitial pneumonitis with mononuclear cells was found in 76.8% of the cases; 53.8% also had foci of septal fibrosis. Leishmania were seen within macrophages in 3 cases only. However, all 10 interstitial pneumonitis cases showed PA...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(89)90712-8

    authors: Duarte MI,da Matta VL,Corbett CE,Laurenti MD,Chebabo R,Goto H

    更新日期:1989-01-01 00:00:00

  • Sero-epidemiology of rubella in Imo State of Nigeria.

    abstract::931 serum samples collected at random from healthy subjects in the four health zones of Imo State were analysed for the presence of rubella haemagglutination inhibition antibodies. Rubella antibodies were present in 625 of the samples giving a prevalence of 66.6%. There was a gradual increase in the prevalence of thes...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1016/0035-9203(85)90114-2

    authors: Gomwalk NE,Ezeronye OU

    更新日期:1985-01-01 00:00:00

  • Podoconiosis: non-infectious geochemical elephantiasis.

    abstract::This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic ...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章,评审

    doi:10.1016/j.trstmh.2007.08.013

    authors: Davey G,Tekola F,Newport MJ

    更新日期:2007-12-01 00:00:00

  • Emergence of Crimean-Congo hemorrhagic fever.

    abstract::Crimean-Congo hemorrhagic fever (CCHF) is a life-threatening tick-borne infection in Africa and Eurasia. Although knowledge of epidemiology is increasing, the global extent and risk of infection is not well described. A niche-modeling framework has been used to map the global distribution of risk for CCHF based on ana...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 评论,杂志文章

    doi:10.1093/trstmh/trv083

    authors: Leblebicioglu H,Ozaras R,Erciyas-Yavuz K

    更新日期:2015-11-01 00:00:00

  • National scale-up of tuberculosis-human immunodeficiency virus collaborative activities in Myanmar from 2005 to 2016 and tuberculosis treatment outcomes for patients with human immunodeficiency virus-positive tuberculosis in the Mandalay Region in 2015.

    abstract:Background:HIV-associated TB is a serious public health problem in Myanmar. Study objectives were to describe national scale-up of collaborative activities to reduce the double burden of TB and HIV from 2005 to 2016 and to describe TB treatment outcomes of individuals registered with HIV-associated TB in 2015 in the Ma...

    journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type: 杂志文章

    doi:10.1093/trstmh/trx073

    authors: Theingi P,Harries AD,Wai KT,Shewade HD,Saw S,Win T,Thein S,Kyi MS,Nyunt Oo H,Aung ST

    更新日期:2017-09-01 00:00:00