当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > Prevalence of drug resistant TB among outpatients at an HIV/TB clinic in Lilongwe, Malawi.

Prevalence of drug resistant TB among outpatients at an HIV/TB clinic in Lilongwe, Malawi.

Abstract：

BACKGROUND:We sought to determine the prevalence of drug resistant TB among outpatients initiating TB treatment in Lilongwe, Malawi. METHODS:This was a prospective cohort study of patients 18 years and older initiating TB treatment at Martin Preuss Centre, the primary integrated HIV/TB clinic in Lilongwe, Malawi, from April 2011 to July 2012. Procedures included questionnaires, physical exam, chest x-ray, full blood count and sputum collection. Sputum samples underwent acid-fast bacilli (AFB) smear testing and culture by Lowenstein-Jensen (LJ) and liquid Mycobacteria Growth Indicator Tube (MGIT) methods. Drug sensitivity was investigated using the Hain GenoType MTBDRplus line probe assay. RESULTS:Of the 702 patients, 219 (31.2%) were female and 653 (93.0%) were presenting for first-time TB treatment. HIV co-infection was present in 420 (59.8%) cases, with 137 (32.6%) of those patients receiving antiretroviral therapy at presentation. TB was culture-confirmed in 375 (53.4%) patients, 349 of which were first time treatment and 26 retreatment. Ten cases of isoniazid-resistant TB (2.9% of culture confirmed cases of newly treated TB), one of rifampin-resistant TB (0.3% culture confirmed cases of newly treated TB) and one of multi-drug resistant TB (MDR-TB) (3.8% of culture confirmed cases of retreatment TB) were detected. CONCLUSIONS:MDR-TB prevalence is low among outpatients initiating TB treatment in Lilongwe.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Barnett B,Gokhale RH,Krysiak R,Kanyemba C,Chikaonda T,Bokosi M,Mukuzunga C,Saidi F,Phiri S,Hoffman IF,Hosseinipour MC

doi

10.1093/trstmh/trv092

subject

Has Abstract

pub_date

2015-12-01 00:00:00

pages

763-8

issue

12

eissn

0035-9203

issn

1878-3503

pii

trv092

journal_volume

109

pub_type

杂志文章

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