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Serum concentrations of chloroquine in a patient with a late recrudescence of Kenyan Plasmodium falciparum malaria.

Abstract：

:A Swedish tourist who had visited Kenya fell ill with Plasmodium falciparum malaria 11 days after returning home, in spite of taking pyrimethamine (50 mg weekly) as malaria prophylaxis. Chloroquine treatment (25 mg base/kg body-weight) giving serum concentrations of 0.30 mumol/l cleared the patent parasitaemia and the patient recovered. Recrudescence occurred, however, within 42 days. A second chloroquine course (30 mg base/kg) gave serum levels up to 1.28 mumol/l. The patient improved rapidly and remained healthy during 28 days without renewed parasitaemia. Further follow-up for 10 months was uneventful. We consider it urgent to assess chloroquine concentrations in serum in patients being treated for falciparum malaria in order to obtain data on fully effective levels. Ineffective serum levels should be ruled out in cases not responding to chloroquine, especially when chloroquine-resistance is suspected.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Faehlmann M,Rombo L,Hedman P

doi

10.1016/0035-9203(81)90093-6

subject

Has Abstract

pub_date

1981-01-01 00:00:00

pages

362-4

issue

3

eissn

0035-9203

issn

1878-3503

journal_volume

75

pub_type

杂志文章

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