Abstract：
:Although diethylcarbamazine (DEC) and albendazole are recommended to interrupt transmission of Wuchereria bancrofti, little is known about the macrofilaricidal effect of this drug combination. Forty-seven men with W. bancrofti infection were randomly assigned to receive a single dose of either DEC alone (6 mg/kg) (n=25) or a combination of DEC (6 mg/kg) and albendazole (400 mg) (n=22). Physical examinations for scrotal nodules (resulting from worm death) and ultrasound examinations (to detect living adult worms) were performed before treatment and 7, 14, 30, 45, 60, 90, 180, 270 and 360 days after treatment. Blood was examined for microfilariae before and 30 days and 360 days after treatment. Seven days post treatment, intrascrotal nodules were detected at the site of 21 (46.7%) adult worm nests in men who received DEC alone compared with 2 (6.1%) sites in men who received DEC and albendazole (P=0.002). One year after treatment, 10 (22.2%) original adult worm nests remained detectable by ultrasound among men who received DEC alone compared with 18/32 (56.3%) nests among men who received both drugs (P=0.016). Microfilaraemia prevalence and density decreased to a similar extent in both groups. Addition of albendazole appeared to decrease the macrofilaricidal effect of DEC against W. bancrofti, with no detectable enhancement in microfilarial suppression.
journal_name
Trans R Soc Trop Med Hygauthors
Dreyer G,Addiss D,Williamson J,Norões Jdoi
10.1016/j.trstmh.2006.04.006subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1118-25issue
12eissn
0035-9203issn
1878-3503pii
S0035-9203(06)00142-8journal_volume
100pub_type
杂志文章,随机对照试验abstract：:One-third of the world's population burn organic material such as wood, dung or charcoal (biomass fuel) for cooking, heating and lighting. This form of energy usage is associated with high levels of indoor air pollution and an increase in the incidence of respiratory infections, including pneumonia, tuberculosis and c...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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abstract：:Actinomycotic liver abscess was diagnosed in a 35-year-old alcoholic farmer from southern India with tender hepatomegaly and fever. CT of the abdomen revealed three coalescing hypodense lesions in the liver. The causative organism could be demonstrated on direct microscopy and cultured from the pus. Treatment with i.v...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2007-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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更新日期：2007-12-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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更新日期：1990-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(75)90157-1
更新日期：1975-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:We aimed to investigate the outcome of children with Japanese encephalitis (JE) and to examine the predictors of the outcome. METHODS:We reviewed the medical records of children with laboratory-confirmed Japanese encephalitis hospitalized in Children's Hospital of Chongqing Medical University in 2010. At le...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trt064
更新日期：2013-10-01 00:00:00
abstract：Background:After new analysis, Sanofi Pasteur now recommends their dengue vaccine (Dengvaxia) should only be given to individuals previously infected with dengue and the World Health Organization's recommendations regarding its use are currently being revised. As a result, the potential costs of performing large-scale ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/try057
更新日期：2018-08-01 00:00:00
