Trypanosoma cruzi stocks isolated from acute Chagas disease patients lead to lethal murine infection.

Abstract:

:Ten Trypanosoma cruzi stocks recently isolated from patients in acute and chronic phases of Chagas disease were inoculated to susceptible (A/Sn) mice. The mice were inoculated with 10(4) trypomastigotes intraperitoneally and monitored for parasitaemia and mortality for up to 300 d. The results demonstrated that (i) T. cruzi stocks isolated from patients in the acute phase killed animals, while stocks from patients in the chronic phase did not; (ii) survival curves differed statistically among mice infected with lethal stocks, and (iii) parasite burden did not affect the mortality rate of mice.

authors

Oliveira EC,Stefani MM,Campos DE,Andrade AL,Silva SA,Rassi A,Luquetti AO

doi

10.1016/s0035-9203(97)90381-3

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

25-7

issue

1

eissn

0035-9203

issn

1878-3503

journal_volume

91

pub_type

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