Abstract：
:The impact of concomitant human immunodeficiency virus (HIV) infection on the antibody response of onchocerciasis patients to Onchocerca volvulus antigens (OvAg) was studied by Western blotting and enzyme linked immunosorbent assay (ELISA). Immunoglobulin G (IgG) antibodies in sera from 45 HIV-sero-positive O. volvulus microfilariae (mf) carriers (HIV+/Ov+) recognized significantly fewer distinct O. volvulus antigenic bands, and responded less frequently to all detected bands compared to sera from 61 matched HIV-seronegative mf carriers (HIV-/Ov+). 29% of 31 follow-up sera from the HIV+/Ov+ patients failed to react to many of the antigenic bands recognized by initial sera from the same patients. Among 4 HIV+/Ov+ persons examined for total CD4+ cells, loss of reactivity corresponded with low CD4+ total cell counts. In an OvAg ELISA, sera from the HIV+/Ov+ individuals had significantly lower IgG+IgM antibody levels than sera from the HIV-/Ov+ persons, and the sensitivity of the assay was 87% for the HIV+/Ov+ subjects compared to 100% for those who were HIV-/Ov+. It is concluded that HIV-infected onchocerciasis patients exhibit significantly impaired antibody responses to O. volvulus antigens, and tend to lose their reactivity to these antigens over time due to immune response abnormalities caused by the concomitant HIV infection.
journal_name
Trans R Soc Trop Med Hygauthors
Tawill SA,Gallin M,Erttmann KD,Kipp W,Bamuhiiga J,Büttner DWdoi
10.1016/s0035-9203(96)90488-5subject
Has Abstractpub_date
1996-01-01 00:00:00pages
85-9issue
1eissn
0035-9203issn
1878-3503journal_volume
90pub_type
杂志文章abstract：:The neglected tropical disease (NTD) agenda should include a focus on disability when 'planning for the next decade of progress'. Millions of people are currently living with the disabling consequences of NTDs and mental health conditions are frequent among people living with NTDs. Stigma around NTDs is also common. H...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/traa160
更新日期：2020-12-12 00:00:00
abstract：:Antibody to the repetitive domain of the Plasmodium falciparum circumsporozoite (CS) protein was measured in blood collected over 3 consecutive months from 224 residents of a hyperendemic focus in Thailand. An enzyme-linked immunosorbent assay incorporating the protein ([NANP]15 + NVDP)2 was used. More than 22% of adu...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90256-e
更新日期：1990-03-01 00:00:00
abstract：:Conventional malaria surveys based on the microscopic examination of blood do not always detect chronic, low-grade infections caused by immunity. A model incorporating differences in detectability within the host population shows how the false negative tests caused by poor detectability confound measures of prevalence...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(82)90219-x
更新日期：1982-01-01 00:00:00
abstract：:A fibroblast-like cell line derived from the mountain vole Microtus montanus was effective in promoting an increase in the multiplication rate of new and established isolates of Plasmodium falciparum. An increase in multiplication rate was also achieved in the absence of M. montanus cells when cultures of P. falciparu...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90017-9
更新日期：1990-07-01 00:00:00
abstract：:A serological survey was carried out to determine the frequency of distribution of hydatid antibodies in Pondicherry during 1981 to 1984. 1325 apparently normal sera and 109 sera from clinically suspected hydatid disease cases were screened by the indirect haemagglutination (IHA) test. Results showed a diagnostic titr...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90037-x
更新日期：1987-01-01 00:00:00
abstract：BACKGROUND:The study aimed to determine factors contributing to the acceptability of home-based HIV counselling and testing (HBHCT) among commuters in Johannesburg inner city. METHODS:Simple random sampling was used to select participants in a venue based intercept survey at Noord Street taxi rank in Johannesburg cent...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/tru122
更新日期：2014-10-01 00:00:00
abstract：:Four cases manifesting features characteristic of epidemic dropsy following body massage with contaminated mustard oil are reported. A transcutaneous route of absorption for the toxin (sanguinarine) resulting in epidemic dropsy has not been documented previously in man. Oil used for body massage was found to be adulte...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(85)90079-3
更新日期：1985-01-01 00:00:00
abstract：:We describe 3 returned travellers who developed profuse watery diarrhoea associated with marked blood eosinophilia. Delayed appearance of ova in stool samples caused difficulty in establishing diagnoses of acute hookworm infection. Low activity of ivermectin against hookworm resulted in failure of empiric treatment wi...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)90073-3
更新日期：2003-07-01 00:00:00
abstract：:The new OptiMAL-IT(R) rapid diagnostic test for malaria was evaluated in 271 patients in Thailand with uncomplicated malaria between June and July 2002. The sensitivity and specificity for the diagnosis of Plasmodium falciparum parasites were 88% and 92%, respectively. For species other than P. falciparum, the sensiti...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)80100-1
更新日期：2003-11-01 00:00:00
abstract：:The bacteria isolated on aerobic and anaerobic culture were compared in 80 unilateral ulcers in patients with homozygous sickle cell (SS) disease, 62 superficial skin lesions, and in 30 diabetic ulcers. In SS disease, the bacterial flora was predominantly aerobic and polymicrobial with Staphylococcus aureus, Pseudomon...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(86)90137-9
更新日期：1986-01-01 00:00:00
abstract：BACKGROUND:In urbanized, low-income cities with high rates of congestion, delivery of antiepileptic drugs (AEDs) by unmanned aerial vehicles (drones) to people with epilepsy for both emergency and non-urgent distribution may prove beneficial. METHODS:Conakry is the capital of the Republic of Guinea, a low-income sub-S...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trz131
更新日期：2020-04-08 00:00:00
abstract：:Leishmanial antigen in circulating immune complexes (CIC) from sera of cotton-rats experimentally infected with Leishmania donovani and visceral leishmaniasis patients (VLP) was detected using a polyethylene glycol (PEG) enzyme-linked immunosorbent assay (PEG-ELISA). The immune complexes were precipitated in the cold ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(94)90502-9
更新日期：1994-01-01 00:00:00
abstract：:Three strains of Trypanosoma cruzi, used previously as prototypes for a classification based on the host-parasite relationships, as well as several stocks isolated from different geographical areas in Brazil, were submitted to isoenzymic analysis. Their isoenzyme patterns revealed a clear correlation with the biologic...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(83)90292-4
更新日期：1983-01-01 00:00:00
abstract：:Accurate identification of Leishmania species is important for monitoring clinical outcome, adequately targeting treatment, and evaluation of epidemiological risk in tegumentary leishmaniasis. This is especially the case in regions where several species coexist and for travel medicine where the geographical source of ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)90031-9
更新日期：2003-01-01 00:00:00
abstract：:The haemolymph of Panstrongylus megistus, infected by Trypanosoma cruzi, was examined by light and electron microscopy. Numerous parasites lie inside the haemocytes, each one in a vacuole. Their well-preserved morphological features support the concept of parasite multiplication in cells of the insect haemolymph. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90164-7
更新日期：1987-01-01 00:00:00
abstract：:Mice were immunized with 0.25 ml culture supernatant intraperitoneally and challenged with 5 x 10(4) Naegleria fowleri intranasally. Survival rate was 11% after one and 25% after three immunizing doses, compared to 0% in controls. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(79)90021-x
更新日期：1979-01-01 00:00:00
abstract：:Cutaneous leishmaniasis in Mexico was first described in 1912. Since then, its existence has been repeatedly confirmed in the forest regions of the peninsula of Yucatan. In order to obtain reliable knowledge about the magnitude of this problem, we questioned and skin-tested a sample of 449 persons randomly selected fr...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90262-d
更新日期：1990-03-01 00:00:00
abstract：:One hundred and eighteen patients with acute falciparum malaria were randomized into treatment with either intramuscular or oral sulfadoxine-pyrimethamine (Fansidar, Roche) and the results were compared with those from 68 patients treated in parallel with chloroquine. Parasitological cure rate was 97% with oral sulfad...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0035-9203(90)90131-w
更新日期：1990-09-01 00:00:00
abstract：:This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2007.08.013
更新日期：2007-12-01 00:00:00
abstract：BACKGROUND:Early identification of patients at risk of severe dengue disease (DD) is critical to guide its management. We evaluated whether the atypical lymphocyte count (ALC), generated from the Sysmex automated full blood count analyzer, is predictive of severe thrombocytopenia secondary to Dengue infection. METHODS...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trz128
更新日期：2020-06-01 00:00:00
abstract：:The objectives of this study were to establish the prevalence of Chagas' disease among HIV seropositive patients and to define the clinical profile of co-infected cases. Cross-sectional study: the prevalence of co-infected subjects was 1.3% and there was no significant difference between co-infected and non co-infecte...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2010.02.004
更新日期：2010-07-01 00:00:00
abstract：:Visceral leishmaniasis (VL) was first reported in Pakistan over 30 years ago from the remote north-eastern Himalayan region. Sporadic cases are now widely reported from the Northern Areas, part of North-West Frontier Province (NWFP) and Punjab Province, together with Azad Jammu and Kashmir (AJK). Two hundred and thirt...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(95)90644-4
更新日期：1995-01-01 00:00:00
abstract：:The pathophysiology of coma in cerebral malaria (CM) is not well understood. Obstruction of microcirculatory flow is thought to play a central role, but other hypotheses include roles for parasite- and host-derived factors such as immune mediators, and for increased blood-brain barrier permeability leading to raised i...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2008.11.003
更新日期：2009-07-01 00:00:00
abstract：:In order to estimate the importance as a public health problem of skin diseases, we investigated the prevalence and severity of skin diseases in a representative sample of children in Mali. 1817 children were randomly selected in 30 clusters by probability-proportional-to-size sampling in Koulikoro region. The mean pr...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(95)90068-3
更新日期：1995-09-01 00:00:00
abstract：:Among many other factors, malaria plays a major causative role of anaemia globally. The mechanisms leading to anaemia in the course of malaria are extremely diverse, involving immunological factors that act differently according to age and malaria epidemiology. The malaria-attributable fraction of anaemia may then dif...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/tru012
更新日期：2014-04-01 00:00:00
abstract：:The avidin-biotin immunohistochemical (ABC) method was applied to the diagnosis of alveolar hydatid disease in patients from the hyperendemic region of western Alaska. The test was specific for larval cestodes of the genus Echinococcus, and exhibited high sensitivity. A negative reaction was obtained in all cases in w...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90219-2
更新日期：1988-01-01 00:00:00
abstract：:The effect of transmission of Schistosoma mansoni of a focal snail control programme was investigated over four years amongst approximately 1250 people living in five communities in the steep-sided Soufriere river valley, St. Lucia, West Indies. Bayer 6076 was applied from constant flow drip cans to 12 stream sections...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(81)90415-6
更新日期：1981-01-01 00:00:00
abstract：:The fibre-web technique for sampling, storing and transport of venous or capillary blood has been evaluated, in 84 schoolchildren from the Mwanza region of Tanzania, with regard to diagnostic efficacy for determination of the schistosome circulating anodic antigen (CAA) under conditions similar to those prevailing in ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(01)90323-2
更新日期：2001-01-01 00:00:00
abstract：:The seroprevalence of hepatitis C virus was evaluated in blood donors and antenatal clinic attenders in Kumasi, Ghana and seropositive subjects were tested for hepatitis C virus ribonucleic acid by the polymerase chain reaction (PCR). The overall seroprevalence among Ghanaians was 2.8% but there was a significantly hi...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(98)90887-2
更新日期：1998-09-01 00:00:00
abstract：:Recent investigations on the distribution of human and canine leishmaniasis, and on the vectors and wild reservoirs of the disease in foci in Tuscany have stimulated a retrospective evaluation of human leishmaniasis of the whole region. From a study of the literature, of statistical reports (ISTAT) and of unpublished ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(81)90087-0
更新日期：1981-01-01 00:00:00
