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Intrinsic individual differences in circumsporozoite antibody response at a hyperendemic malaria focus.

Abstract：

:Antibody to the repetitive domain of the Plasmodium falciparum circumsporozoite (CS) protein was measured in blood collected over 3 consecutive months from 224 residents of a hyperendemic focus in Thailand. An enzyme-linked immunosorbent assay incorporating the protein ([NANP]15 + NVDP)2 was used. More than 22% of adults produced high antibody titres in all 3 months, even though transmission had stopped. Malaria prevalence in these high-responders was the same as in the rest of the population and the number of consanguineous high-responders was no higher than would be expected by chance. The data suggest that individuals at prolonged, equal risk of malaria inoculation display intrinsic differences in their ability to produce CS antibody.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Rosenberg R,Wirtz RA

doi

10.1016/0035-9203(90)90256-e

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

206-8

issue

2

eissn

0035-9203

issn

1878-3503

journal_volume

84

pub_type

杂志文章

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