Parenteral sulphadoxine-pyrimethamine (Fansidar): an effective and safe but under-used method of anti-malarial treatment.

abstract：:Codon usage bias is a feature of living organisms. The origin of this bias might be explained not only by external factors but also by the nature of the structure of deoxyribonucleic acid (DNA) itself. We have developed a point mutation simulation program of coding sequences, in which nucleotide replacement follows th...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Zimic MJ,Guerra D,Arévalo J

更新日期：2002-04-01 00:00:00

abstract：:The natural host of Plasmodium knowlesi is the kra monkey, Macaca fascicularis, but this parasite, initially mistaken for P. malariae, is now infecting humans in some areas of Southeast Asia. Here we present data from experiments performed in the 1970s in which sera from a few naive M. fascicularis, taken in the cours...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Butcher GA,Mitchell GH,Cohen S

更新日期：2010-01-01 00:00:00

abstract：Background:Chronic hepatitis B infection affects 240 million people, with the highest prevalence in Africa and Asia, and results in 700 000 deaths annually. Access to diagnostics, particularly for hepatitis B virus viral load quantification (HBV DNA), is a major barrier to treatment. We aimed to test World Health Organ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Laing N,Tufton H,Ochola E,P'Kingston OG,Maini MK,Easom N

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Hump-nosed pit vipers (Hypnale hypnale) are highly venomous snakes found in Sri Lanka and the Western Ghats region of India. They are the most common cause of venomous snakebites in Sri Lanka, mainly causing local envenoming leading to pain, swelling and necrosis. Systemic envenoming causing acute kidney inj...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Rathnayaka RMMKN,Ranathunga PEAN,Kularatne SAM

更新日期：2019-03-01 00:00:00

abstract：:Improved awareness of Pap test by Nigerian women may not necessarily increase its use. This hypothesis was tested using female medical practitioners in Enugu state, Nigeria. They were expected to be advocates of disease screening and therefore should lead by example. All respondents were aware of the Pap smear but onl...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Dim CC,Ekwe E,Madubuko T,Dim NR,Ezegwui HU

更新日期：2009-08-01 00:00:00

abstract：:A serological survey was carried out to determine the frequency of distribution of hydatid antibodies in Pondicherry during 1981 to 1984. 1325 apparently normal sera and 109 sera from clinically suspected hydatid disease cases were screened by the indirect haemagglutination (IHA) test. Results showed a diagnostic titr...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Parija SC,Sasikala A,Rao RS

更新日期：1987-01-01 00:00:00

abstract：:The market for antimalarial drugs consists of the 2.8 billion (2.8 x 10(9) people living in malaria endemic areas and about 20-30 million people, mainly Europeans and North Americans, who travel or live in malarious areas, and the wealthy elite of malarious developing countries. Some of the largest markets include Chi...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Foster S

更新日期：1994-06-01 00:00:00

abstract：:Lymphatic filariasis (LF) caused by Wuchereria bancrofti is widely prevalent in tropical and subtropical countries. Night blood film examination is most commonly used for diagnosis of filariasis but is cumbersome and labour intensive. In order to develop an indirect ELISA-based immunodiagnostic test, the importance of...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Singh A,Kamal S,Rathaur S

更新日期：2010-08-01 00:00:00

abstract：:Investigations to characterize the in vitro reaction of serum-mediated leucocyte-adherence to microfilariae of Wuchereria bancrofti were carried out in Tanzania. The adherence reaction took place within one hour and at least two serum factors were involved: a heat-labile factor, present also in normal serum (probably ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Simonsen PE

更新日期：1983-01-01 00:00:00

abstract：:A pole estimating, for each individual, the number of praziquantel tablets needed for treatment according to height was tested in 20 data sets (n = 25,688). In more than 98% of the cases the indicated dose was within the range that has proven efficacious and safe (30 and 60 mg/kg). ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Montresor A,Engels D,Chitsulo L,Bundy DA,Brooker S,Savioli L

更新日期：2001-09-01 00:00:00

abstract：:The pathophysiology of coma in cerebral malaria (CM) is not well understood. Obstruction of microcirculatory flow is thought to play a central role, but other hypotheses include roles for parasite- and host-derived factors such as immune mediators, and for increased blood-brain barrier permeability leading to raised i...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Maude RJ,Dondorp AM,Abu Sayeed A,Day NP,White NJ,Beare NA

更新日期：2009-07-01 00:00:00

abstract：:The Andaman and Nicobar Islands, Union Territory of India, are home to six primitive tribes, namely the Great Andamanese, Onges, Jarawas and Sentinelese (Negrito race), and the Shompens and Nicobarese (Mongoloid race). These tribes account for about 8% of the island's population and the Nicobarese constitute >95% of t...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Murhekar MV,Murhekar KM,Sehgal SC

更新日期：2008-08-01 00:00:00

abstract：:Routine results of direct examination of sputum smears for acid-fast bacilli from 34 laboratories in Tanzania were analysed. These represented 8 regions providing 94 laboratory-years of work; 61,580 tuberculosis suspects were evaluated with the aid of 141,371 smears. The average proportion of cases found among suspect...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ipuge YA,Rieder HL,Enarson DA

更新日期：1996-05-01 00:00:00

abstract：:From 1993 to 1996, an entomological survey was conducted in the village of Ndiop, Senegal, as part of a research programme on malaria epidemiology and the mechanisms of protective immunity. Mosquitoes were captured on human bait and by indoor spraying. Species from the Anopheles gambiae complex were identified using t...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Fontenille D,Lochouarn L,Diatta M,Sokhna C,Dia I,Diagne N,Lemasson JJ,Ba K,Tall A,Rogier C,Trape JF

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Rio de Janeiro (RJ) has been of major importance for the epidemiology of dengue viruses (DENVs) in Brazil. After the DENV 1-4 introductions in 1986, 1990, 2000 and 2011, respectively, the state has suffered explosive epidemics. We aimed to describe laboratorial, epidemiological and clinical aspects due to th...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Heringer M,Nogueira RM,de Filippis AM,Lima MR,Faria NR,Nunes PC,Nogueira FB,dos Santos FB

更新日期：2015-04-01 00:00:00

abstract：:Serological testing of paired (i.e. admission and convalescent) sera from 103 fever patients in Kathmandu, Nepal, was performed to estimate the prevalence rates of scrub typhus, murine typhus, Leptospira and dengue virus antibodies and to determine their role in the cause of active infections. Blood cultures from 15 p...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Blacksell SD,Sharma NP,Phumratanaprapin W,Jenjaroen K,Peacock SJ,White NJ,Pukrittayakamee S,Day NP

更新日期：2007-07-01 00:00:00

abstract：:Allopurinol and allopurinol ribonucleoside tested in vitro and in vivo for activity against Leishmania donovani. Activity in vitro was low against the amastigote form of this parasite with ED50 values of the order of 54 and 96 microM and 86 and 213 microM respectively for the two compounds. In vivo inhibition of up to...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Neal RA,Croft SL,Nelson DJ

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Two long sewerage canals in the city of Kolkata, India were heavily infested with larvae, pupae and egg rafts of the mosquito Culex quinquefasciatus. Although the burden of bancroftian filariasis and other diseases transmitted by C. quinquefasciatus in the city is practically zero, the night-biting mosquitoe...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Biswas D,Mandal B,Biswas B,Banerjee A,Mukherjee TK

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVES:Mid-upper arm circumference (MUAC) and weight-for-height Z-score (WHZ) identify different populations of children with severe acute malnutrition (SAM) with only some degree of overlap. In an urban slum in Bangladesh, we conducted a prospective cohort study on children assessed as being severely malnourished ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ali E,Zachariah R,Shams Z,Vernaeve L,Alders P,Salio F,Manzi M,Allaouna M,Draguez B,Delchevalerie P,Harries AD

更新日期：2013-05-01 00:00:00

abstract：:The relation between Plasmodium falciparum malaria and symptomatic human immunodeficiency virus 1 (HIV-1) infection was investigated in paediatric and adult patients in Kampala, Uganda, from 1987 to 1989. Both infections contributed largely to hospital morbidity. Of 1527 clinically suspicious in-patients, 61% were pos...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Müller O,Moser R

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:The study aimed to determine factors contributing to the acceptability of home-based HIV counselling and testing (HBHCT) among commuters in Johannesburg inner city. METHODS:Simple random sampling was used to select participants in a venue based intercept survey at Noord Street taxi rank in Johannesburg cent...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Muloongo K,Tshuma N,Chimoyi L,Setswe G,Sarfo B,Nyasulu P

更新日期：2014-10-01 00:00:00

abstract：:Mapping an area at risk of epidemics of meningococcal meningitis in Africa has significant implications for their prevention and case treatment, through the targeted development of improved surveillance systems and control policies. Such an area was described using information obtained from published and unpublished r...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Molesworth AM,Thomson MC,Connor SJ,Cresswell MP,Morse AP,Shears P,Hart CA,Cuevas LE

更新日期：2002-05-01 00:00:00

abstract：:Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no de...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Cook GC

更新日期：1978-01-01 00:00:00

abstract：:Trypanosoma cruzi (Brazil strain) was maintained in liver infusion tryptose and medium supplemented with 5 or 10% foetal calf serum at 27 degrees C on a rotating shaker platform. 85 to 95% of the organisms under these conditions are epimastigotes and the medium supported logarithmic growth for up to 24 hours. The effe...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Nadler JP,Lederer E,Wittner M,Baum SG,Tanowitz HB

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Turkey has a national tuberculosis (TB) control program that follows the standards set by the World Health Organization's (WHO) global TB control program. METHODS:In this record-based retrospective study, contact screening and chemoprophylaxis of 469 TB contacts registered at the Samsun Tuberculosis Dispens...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Dundar C,Oztomurcuk D,Terzi O

更新日期：2019-06-01 00:00:00

abstract：:In vitro gametocytogenesis of Plasmodium falciparum was observed in all 22 isolates established in this laboratory. Gametocytes were produced in variable numbers--up to 3% of red cells--for a limited period of time after which this stage was seen only very sporadically. Complete maturation of microgametocytes in vitro...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Ponnudurai T,Meuwissen JH,Leeuwenberg AD,Verhave JP,Lensen AH

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Antibiotic resistance is a global health crisis and irrational prescribing behaviour has been identified as a contributing factor. The current study aimed to assess the knowledge of, attitudes towards and practices regarding antibiotic prescribing of medical doctors providing free healthcare services in the ...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Kabba JA,Tadesse N,James PB,Kallon H,Kitchen C,Atif N,Jiang M,Hayat K,Zhao M,Yang C,Chang J,Fang Y

更新日期：2020-06-01 00:00:00

abstract：:The assessment of antimicrobial resistance among commensal bacteria is an indicator of the spread of antimicrobial resistance. Rapid screening methods for detection of antimicrobial-resistant faecal Escherichia coli directly on MacConkey plates have been successfully adopted but suffer from lack of standardisation. Th...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Bartoloni A,Benedetti M,Pallecchi L,Larsson M,Mantella A,Strohmeyer M,Bartalesi F,Fernandez C,Guzman E,Vallejos Y,Villagran AL,Guerra H,Gotuzzo E,Paradisi F,Falkenberg T,Rossolini GM,Kronvall G

更新日期：2006-02-01 00:00:00

abstract：:A sensitive and specific polymerase chain reaction (PCR) based on a highly repeated deoxyribonucleic acid (DNA) sequence (188 bp; SspI repeat) was tested for the detection of Wuchereria bancrofti DNA in blood and urine samples collected during the day from individuals in Coque, Recife, Brazil, an endemic area for W. b...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Lucena WA,Dhalia R,Abath FG,Nicolas L,Regis LN,Furtado AF

更新日期：1998-05-01 00:00:00

abstract：:Between May and September 1982 an extensive epidemic of poliomyelitis occurred in Gazankulu in the north-eastern region of South Africa, with a total of 260 paralysed cases and 42 deaths. A three-part study was instituted, the first of which established the aetiological agent of the epidemic to be poliovirus type 1. T...

journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

authors： Johnson S,Schoub BD,McAnerney JM,Gear JS,Moodie JM,Garrity SL,Klaassen KI,Küstner HG

更新日期：1984-01-01 00:00:00