Abstract：
BACKGROUND:Hump-nosed pit vipers (Hypnale hypnale) are highly venomous snakes found in Sri Lanka and the Western Ghats region of India. They are the most common cause of venomous snakebites in Sri Lanka, mainly causing local envenoming leading to pain, swelling and necrosis. Systemic envenoming causing acute kidney injury and coagulopathy are more commonly recognized following their bites. METHOD:A series of 465 patients with hump-nosed viper bites was prospectively studied over four years from January 2014. All patients were assessed and the data were collected by the principal investigator (primary data). RESULTS:Forty-four (9.5%) patients developed acute kidney injury, of which 23 (5%) were proven cases and 21 (4.5%) were probable cases. Of the proven cases, 4 (17%) progressed to chronic kidney disease and 12 (52%) had thrombotic microangiopathy, from which 11 (48%) developed haemolytic uremic syndrome and 1 (4%) had thrombotic thrombocytopenic purpura. Twelve (52%) showed microangiopathic haemolysis and 15 (65%) had thrombocytopenia. Oliguria was observed in 10 (43%) whereas 7 (30%) each had anuria and normal urine output. Ten patients (43%) developed haematuria, from which 6 had microscopic haematuria and 4 had macroscopic haematuria. Proteinuria was observed in 8 (35%). Coagulopathy developed in 3 (13%) patients. In probable cases, 3 (14%) died due to complications of kidney injury. CONCLUSION:A significant proportion of patients develop acute kidney injury following hump-nosed pit viper bite. Who will develop acute kidney injury or succumb to the venom is unpredictable. Reliable and accessible treatments are a critical unmet need.
journal_name
Trans R Soc Trop Med Hygauthors
Rathnayaka RMMKN,Ranathunga PEAN,Kularatne SAMdoi
10.1093/trstmh/try120subject
Has Abstractpub_date
2019-03-01 00:00:00pages
131-142issue
3eissn
0035-9203issn
1878-3503pii
5244184journal_volume
113pub_type
杂志文章abstract：:30 pairs of patients with complicated Plasmodium falciparum malaria (with anaemia, hyperpyrexia, jaundice or more than 5% of erythrocytes parasitized) were studied. Patients with cerebral signs and symptoms were excluded. One group of patients was treated with oral mefloquine (750 mg) and artemether (600 mg by injecti...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章
doi：10.1016/0035-9203(88)90187-3
更新日期：1988-01-01 00:00:00
abstract：:Tungiasis (jigger) is endemic in many impoverished communities in many parts of Brazil. Forty-seven individuals entering an endemic area were followed up for a period of six weeks and regularly examined for the presence of newly embedded sand fleas. At the end of the third week, the attack rate of Tunga penetrans infe...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2004-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(82)90093-1
更新日期：1982-01-01 00:00:00
abstract：:112 Leishmania isolates, obtained in French Guiana from human lesions, phlebotomine sandflies and wild mammals, were characterized by isoenzyme electrophoresis. Leishmania braziliensis guyanensis and L. mexicana amazonensis were found parasitizing different natural hosts. L.b. guyanensis was the dominant species (103 ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(89)90373-8
更新日期：1989-09-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trz128
更新日期：2020-06-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)80006-8
更新日期：2003-09-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2008.10.018
更新日期：2009-12-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90371-3
更新日期：1987-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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doi：10.1016/s0035-9203(00)90264-5
更新日期：2000-03-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,多中心研究
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更新日期：2006-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trv092
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1093/trstmh/tru198
更新日期：2015-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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doi：10.1016/0035-9203(87)90383-x
更新日期：1987-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(92)90569-x
更新日期：1992-03-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(94)90502-9
更新日期：1994-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(95)90476-x
更新日期：1995-03-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)90073-3
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(82)90188-2
更新日期：1982-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(80)90194-7
更新日期：1980-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 评论,杂志文章
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更新日期：2015-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(85)90339-6
更新日期：1985-01-01 00:00:00
abstract：BACKGROUND:Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012-2013, we documented that acute dengue was surprisingly associated with self-reported rural residence in the Southern Province of Sri Lanka. METHODS:Patients admitted with an acute...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/trz123
更新日期：2020-06-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(01)90034-3
更新日期：2001-09-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(85)90069-0
更新日期：1985-01-01 00:00:00
abstract：:The impact of concomitant human immunodeficiency virus (HIV) infection on the antibody response of onchocerciasis patients to Onchocerca volvulus antigens (OvAg) was studied by Western blotting and enzyme linked immunosorbent assay (ELISA). Immunoglobulin G (IgG) antibodies in sera from 45 HIV-sero-positive O. volvulu...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(96)90488-5
更新日期：1996-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/s0035-9203(03)90010-1
更新日期：2003-01-01 00:00:00
abstract：:Commercially available bovine liver catalase has been used to supplement chemically defined medium for growth of Trypanosoma cruzi. The protein extract was found to be contaminated with 25 to 30 protein bands as well as DNA and RNA polymers. ...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90266-5
更新日期：1987-01-01 00:00:00
abstract：:Between May and September 1982 an extensive epidemic of poliomyelitis occurred in Gazankulu in the north-eastern region of South Africa, with a total of 260 paralysed cases and 42 deaths. A three-part study was instituted, the first of which established the aetiological agent of the epidemic to be poliovirus type 1. T...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(84)90166-4
更新日期：1984-01-01 00:00:00
