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Vaccination and heterologous immunity: educating the immune system.

Abstract：

:This review discusses three inter-related topics: (1) the immaturity of the neonatal and infant immune response; (2) heterologous immunity, where prior infection history with unrelated pathogens alters disease outcome resulting in either enhanced protective immunity or increased immunopathology to new infections, and (3) epidemiological human vaccine studies that demonstrate vaccines can have beneficial or detrimental effects on subsequent unrelated infections. The results from the epidemiological and heterologous immunity studies suggest that the immune system has tremendous plasticity and that each new infection or vaccine that an individual is exposed to during a lifetime will potentially alter the dynamics of their immune system. It also suggests that each new infection or vaccine that an infant receives is not only perturbing the immune system but is educating the immune system and laying down the foundation for all subsequent responses. This leads to the question, is there an optimum way to educate the immune system? Should this be taken into consideration in our vaccination protocols?

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Gil A,Kenney LL,Mishra R,Watkin LB,Aslan N,Selin LK

doi

10.1093/trstmh/tru198

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

62-9

issue

1

eissn

0035-9203

issn

1878-3503

pii

tru198

journal_volume

109

pub_type

杂志文章,评审

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