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Opisthorchis viverrini infection in Thailand: symptoms and signs of infection--a population-based study.

Abstract：

:A population-based study of the clinical, laboratory and ultrasonographic findings in patients suffering from mild or moderate opisthorchiasis in Prachinburi province, Thailand was conducted in 1990-1992. The effectiveness of treatment with praziquantel at 40 mg/kg body weight was evaluated. After treatment, a long-lasting, marked improvement in the well-being of the study group was observed. Symptoms common in opisthorchiasis infection decreased in intensity and the clinical response showed total or partial remission in 98% of all cases studied. Total and direct bilirubin concentrations decreased significantly and remained low up to the end of the follow-up period of 2 years, indicating a reduction in cholestasis. Also, white blood cell counts decreased initially, which can be interpreted as a reduction in inflammation intensity. No relationship was found between intensity of infection and age or clinical findings. Population-based treatment of opisthorchiasis appears to have had a significant impact on public health in north-east Thailand. However, it is also evident that drug therapy alone will not solve the opisthorchiasis problem, as indicated by the reinfection rate of almost 10% at the end of the study.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Pungpak S,Chalermrut K,Harinasuta T,Viravan C,Schelp PF,Hempfling A,Schlattmann P,Bunnag D

doi

10.1016/0035-9203(94)90164-3

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

561-4

issue

5

eissn

0035-9203

issn

1878-3503

journal_volume

88

pub_type

杂志文章

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