当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > Development of renal function abnormalities following bites by Russell's vipers (Daboia russelii siamensis) in Myanmar.

Development of renal function abnormalities following bites by Russell's vipers (Daboia russelii siamensis) in Myanmar.

Abstract：

:Renal function was monitored in 24 patients with systemic envenoming following proven Russell's viper bite. In all patients, blood clotted within 20 min on admission. In 15 cases severe defibrination (systemic envenoming) developed during the next 3-5 d. None of the patients received antivenom before admission but enzyme-refined monospecific antivenom was given to those who developed signs of systemic envenoming. Specific antigen was detected by enzyme immuno-assay in all 21 subjects tested. Nine patients whose renal function remained normal did not develop systemic envenoming, and recovered without any treatment even though venom antigen was detectable in their serum. Ten patients developed mild renal dysfunction and systemic envenoming, but recovered after treatment with antivenom alone. The remaining 5 patients, all of whom were oliguric from admission, developed acute renal failure despite treatment with antivenom, but some recovered after peritoneal dialysis. Serum venom antigen levels were high in the last 2 groups, but there was some overlap. Albuminuria, found only in patients who became systemically envenomed, was associated with high fractional sodium excretion in those who developed acute oliguric renal failure. Albuminuria may appear before a gross clotting defect is detectable. It is an indication for antivenom and spot measurements might prove a useful early predictor of outcome.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Thein-Than,Tin-Tun,Hla-Pe,Phillips RE,Myint-Lwin,Tin-Nu-Swe,Warrell DA

doi

10.1016/0035-9203(91)90307-k

subject

Has Abstract

pub_date

1991-05-01 00:00:00

pages

404-9

issue

3

eissn

0035-9203

issn

1878-3503

journal_volume

85

pub_type

杂志文章

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