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Sensitization against the parasite antigen Sj26 is not sufficient for consistent expression of resistance to Schistosoma japonicum in mice.

Abstract：

:Mice immunized with purified antigen preparations produced in Escherichia coli and containing the glutathione S-transferase (GST) isoenzyme of Schistosoma japonicum (Sj26) can be partially resistant to infection with this parasite. Maximum resistance was approximately 50% and no protection was obtained in BALB/c mice, known low responders to Sj26. Although only Freund's complete adjuvant has been used, the data obtained indicate that satisfactory levels of resistance to S. japonicum will not be attained by vaccination with Sj26 alone. Other antigens, including the additional GST isoenzyme of S. japonicum Sj28, will probably be required to establish whether Sj26 will be an important component of a defined multivalent vaccine against schistosomiasis japonica.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Mitchell GF,Garcia EG,Davern KM,Tiu WU,Smith DB

doi

10.1016/0035-9203(88)90027-2

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

885-9

issue

6

eissn

0035-9203

issn

1878-3503

journal_volume

82

pub_type

杂志文章

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