Abstract:
BACKGROUND:Data regarding the incidence of tuberculosis (TB) among people living with diabetes (PLWD) in TB-endemic settings are scarce. We examined TB incidence among PLWD in Indonesia who had previously been screened for latent TB infection (LTBI) and TB disease. METHODS:PLWD (≥18 y of age) in an urban setting were examined a mean 3.4 y after they had been screened for active TB and LTBI. Data on subsequent TB diagnosis were collected by interview and with chest X-ray, sputum smear and Mycobacterium tuberculosis culture. TB incidence rates were stratified for baseline LTBI status, as determined by the QuantiFERON interferon-gamma release assay (IGRA). RESULTS:Of 590 PLWD, 101 had died and 163 could not be contacted or refused. Among the 326 who were re-examined, 6 (1.8%; 95% confidence interval [CI] 0.7 to 4.0) reported being diagnosed already and a further 5 were diagnosed with active TB (1.5%; 95% CI 0.50 to 3.5). The TB incidence rate was 9.85 (95% CI 4.03 to 15.68) per 1000 person-years. TB incidence was higher among PLWD with baseline LTBI (17.13; 95% CI 5.25 to 29.00/1000 person-years) compared with those without LTBI (4.79; 95% CI -0.63 to 10.21), with an incidence rate ratio of 3.57 (95% CI 0.86 to 20.92; p=0.054). CONCLUSIONS:PLWD with LTBI in Indonesia and similar settings are likely to benefit from TB preventive therapy.
journal_name
Trans R Soc Trop Med Hygauthors
McAllister SM,Koesoemadinata RC,Santoso P,Soetedjo NNM,Kamil A,Permana H,Ruslami R,Critchley JA,van Crevel R,Hill PC,Alisjahbana Bdoi
10.1093/trstmh/trz100subject
Has Abstractpub_date
2020-02-07 00:00:00pages
79-85issue
2eissn
0035-9203issn
1878-3503pii
5619082journal_volume
114pub_type
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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