Abstract：
BACKGROUND:Artemisinin-based combination therapies (ACTs) have proven highly effective in reducing malaria morbidity in sub-Saharan Africa. Artemether-lumefantrine (AL) was introduced in 2005 as a first-line ACT for the treatment of uncomplicated malaria in Rwanda. Monitoring the therapeutic efficacy of ACTs is necessary to ensure effective malaria case management. METHODS:A comparative study on the efficacy of AL and dihydroartemisinin-piperaquine (DHP) was conducted in two sites, Masaka and Ruhuha, between September 2013 and December 2015. Clinical and parasitological responses were assessed at days 28 and 42. RESULTS:A total of 534 children were treated with AL (n=267) or DHP (n=267). After polymerase chain reaction (PCR) adjustment, 98.3% and 98.9% of children in the AL and DHP arms, respectively, achieved an adequate clinical and parasitological response (ACPR) at day 28. At day 42, PCR-adjusted ACPR proportions were 97.3% and 98.4% for AL and DHP, respectively. PCR-adjusted ACPR was 99% for both drugs at days 28 and 42 in Ruhuha. The PCR-adjusted ACPR proportions in Masaka were 97.3% for AL and 98.5% for DHP at day 28 and 95.2% for AL and 97.5% for DHP at day 42. CONCLUSIONS:AL remains efficacious in Rwanda 10 y after its adoption. The probability of new infections occurring among patients in the DHP arm was significantly lower than those in the AL arm. DHP also demonstrated a greater post-treatment prophylactic effect against new infections compared with AL.
journal_name
Trans R Soc Trop Med Hygauthors
Uwimana A,Penkunas MJ,Nisingizwe MP,Warsame M,Umulisa N,Uyizeye D,Musanabaganwa C,Munyaneza T,Ntagwabira E,Hakizimana D,Muvunyi CM,Kayobotsi C,Kabera M,Murindahabi M,Mbituyumuremyi Adoi
10.1093/trstmh/trz009subject
Has Abstractpub_date
2019-06-01 00:00:00pages
312-319issue
6eissn
0035-9203issn
1878-3503pii
5406192journal_volume
113pub_type
杂志文章,随机对照试验abstract：:Twenty-two hydatid cysts have been accurately located in the abdomens of seven patients by ultrasound B-scanning. Lapartomy has confirmed the presence of 19 of these cysts. Grey-scale techniques do not appear to add appreciably to the ease of diagnosis in this condition. Ultrasound can give the clinician a good idea o...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(77)90201-2
更新日期：1977-01-01 00:00:00
abstract：:Using two serological techniques, eight Nigerian West Nile virus isolates were investigated to determine antigenic relationships among them, and to find out if these virus isolates were related to West Nile virus strains from the different zoogeographic areas of the world. One virus differed significantly from the sev...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(76)90175-9
更新日期：1976-01-01 00:00:00
abstract：:Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no de...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(78)90208-0
更新日期：1978-01-01 00:00:00
abstract：:About 85% of the population of two Somali communities harboured soil-transmitted intestinal nematodes and/or protozoa. The commonest parasite (75% in the Lafoole institution and 59% in the Afgoye institution) was Trichuris trichiura. Mixed infections were common. The source of infection is contaminated fields around d...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90256-2
更新日期：1987-01-01 00:00:00
abstract：:Promotion of breastfeeding is a key component of infant health policies globally. However, maternal HIV infection is a possible contraindication for breastfeeding since it can result in mother-to-child transmission. Research into infant-feeding strategies which will promote the health of all infants but also protect a...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/s0035-9203(03)90010-1
更新日期：2003-01-01 00:00:00
abstract：:The precise function of Plasmodium falciparum histidine-rich protein II (HRPII) is not known, but in vitro studies have indicated its immunomodulatory function. The host immune response to HRPII was measured and compared with the response to P. falciparum merozoite surface protein 1 (MSP1) in four groups of study subj...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2010.01.002
更新日期：2010-05-01 00:00:00
abstract：:Counts of nocturnally periodic Wuchereria bancrofti microfilariae (mf) in 20 mm3 finger-prick blood films were compared with membrane counts after filtration of 1 ml of venous blood for their efficacy in determining the prevalence of Bancroftian filariasis. The technique used for spreading and staining the blood films...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(91)90237-s
更新日期：1991-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2011.07.017
更新日期：2011-12-01 00:00:00
abstract：:National tuberculosis control programmes (NTPs) in sub-Saharan Africa do not routinely record or report treatment outcome data on smear-negative pulmonary tuberculosis (PTB) patients. Twelve-month treatment outcome on patients with smear-negative PTB registered in all district and mission hospitals in Malawi during th...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(99)90153-0
更新日期：1999-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(99)90073-1
更新日期：1999-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2009.04.003
更新日期：2009-09-01 00:00:00
abstract：:Tungiasis (jigger) is endemic in many impoverished communities in many parts of Brazil. Forty-seven individuals entering an endemic area were followed up for a period of six weeks and regularly examined for the presence of newly embedded sand fleas. At the end of the third week, the attack rate of Tunga penetrans infe...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2003.12.004
更新日期：2004-07-01 00:00:00
abstract：:The seroprevalence of toxocariasis was investigated in 1997/98 in 1009 schoolchildren (aged 5-12 years) throughout Trinidad. Infection, as measured by titre, was found to be high compared to values obtained from children in other countries. Using an excretory-secretory antigen and performing an ELISA test, it was foun...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(02)90281-6
更新日期：2002-03-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(76)90088-2
更新日期：1976-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(84)90295-5
更新日期：1984-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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更新日期：2013-05-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2008-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1994-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1093/trstmh/tru012
更新日期：2014-04-01 00:00:00
abstract：:Lymphatic filariasis (LF) caused by Wuchereria bancrofti is widely prevalent in tropical and subtropical countries. Night blood film examination is most commonly used for diagnosis of filariasis but is cumbersome and labour intensive. In order to develop an indirect ELISA-based immunodiagnostic test, the importance of...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2010.02.007
更新日期：2010-08-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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更新日期：2008-02-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(98)91063-x
更新日期：1998-07-01 00:00:00
abstract：:The response of Plasmodium falciparum to chloroquine in Zambia was determined by the in vivo and in vitro microtechniques. A total dose of 25mg chloroquine base/kg body weight (over 3 d) was administered to 60 children at Lubwe and 42 at Kalene. The in vivo test was successfully completed on 55 cases at Lubwe and 39 a...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90406-3
更新日期：1988-01-01 00:00:00
abstract：:The use of an indirect fluorescent antibody test (IFAT) performed in a "sandwich" technique has demonstrated: (i) the usefulness of the test for the diagnosis of Trypanosoma cruzi infection in the opossum Didelphis marsupialis; (ii) the existence of differences in the serological response of the opossum, that were rel...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(85)90069-0
更新日期：1985-01-01 00:00:00
abstract：:A Vietnamese child presented with a history of abdominal pain. Shortly afterwards, he vomited eight live trematode flukes that were collected and morphologically identified as Fasciolopsis buski. The identification was confirmed by DNA analysis. Adult worms of F. buski from humans are very rarely seen except at autops...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/s0035-9203(03)00022-1
更新日期：2004-03-01 00:00:00
abstract：:During a five-year period, 45 Nigerians with radiographic appearances of diffuse pulmonary infiltration with at least six sputum specimens negative on culture for tubercule bacilli were investigated at University College Hospital, Ibadan. The value of pulmonary function studies and open or closed lung biopsy in discov...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(79)90171-8
更新日期：1979-01-01 00:00:00
