当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > Community-based research: cost of the tests used for anti-HBc total seropositivity only and hepatitis B screening.

Community-based research: cost of the tests used for anti-HBc total seropositivity only and hepatitis B screening.

Abstract：

:Our study aimed to determine anti-HBc total (IgG+IgM) seroprevalence in the adult population aged ≥ 15 and to compare the cost of testing for HBsAg and anti-HBs in only anti-HBc positive+ subpopulation to that in the whole population for HBV screening. The study involved a face-to-face survey and peripheral blood sampling from 452 adult subjects for HBV tests. HBV-DNA PCR was studied only in anti-HBc+ subjects. Of the 452 subjects anti-HBc total was positive in 192 (42.47%), of which: (a) 27 (14.06%) were HBsAg+, anti-HBs negative⁻, (b) 126 (65.62%) were HBsAg⁻, anti-HBs+, (c) 39 were HBsAg⁻, anti-HBs⁻. This last group (c) were tested for HBV-DNA PCR and six (15.38%) were positive. When we perform HBsAg and anti-HBs tests in all 452 subjects as in routine practice in blood banks, the cost is 3320 Euros. However, when all subjects are tested for anti-HBc total at first and then only anti-HBc total+ ones are tested for HBsAg and anti-HBs, the cost is 2929 Euros. The cost difference between the two methods is 391 Euros for 452 subjects. Accordingly, our HBV screening algorithm brings a financial saving of 11.78% and helps to identify the isolated anti-HBc total+ subjects who carry potential risk for spreading HBV.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Ozkan S,Atak A,Bozdayi G,Turkcuoglu S,Maral I

doi

10.1016/j.trstmh.2010.08.012

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

782-6

issue

12

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(10)00186-0

journal_volume

104

pub_type

杂志文章

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