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Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?

Abstract：

:Resistance to the antifolate sulfadoxine-pyrimethamine (SP), the current mass-treatment antimalarial drug, is associated with selection of point mutations in dihydrofolate reductase and dihydropteroate synthase. Among these mutations, the leucine 164 dihydrofolate reductase mutation (Leu-164) is associated with higher levels of SP resistance; this mutation is also associated with a decrease in the efficacy of chlorproguanil/dapsone, a newly developed antifolate antimalarial drug. Leu-164 has been detected in Southeast Asia and South America, regions where SP is no longer effective. Surprisingly, this mutation has not yet been detected in Africa, using the standard protocol based on PCR-RFLP, despite high SP resistance. In this paper, we discuss briefly the reasons why Leu-164 has not yet been selected in Africa and we propose a means that may slow down the selection of this mutation.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Nzila A,Ochong E,Nduati E,Gilbert K,Winstanley P,Ward S,Marsh K

doi

10.1016/j.trstmh.2004.07.002

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

341-6

issue

5

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(04)00251-2

journal_volume

99

pub_type

杂志文章,评审

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