Abstract:
BACKGROUND:Immunoepidemiologic studies have shown a relationship between IgE and IgG4 antibodies with age and with resistance and susceptibility to infection. It is believed that the IgE and IgG4 responses to soluble egg antigen (SEA) can be used for serological analysis of infection and post-treatment status. This study aimed to evaluate the association between Schistosoma mansoni infection and anti-SEA IgG4 and IgE reactivities, and determine whether these reactivities could be used as biomarkers of infection. METHODS:Between 2001 and 2009, a longitudinal study was performed in which parasitologic and blood specimens and socioeconomic and water-contact information were collected from 127 individuals. All patients positive for S. mansoni infection were treated. RESULTS:Schistosomiasis prevalence and the geometric mean of the egg count in 2001 were 59% and 61.05, respectively, decreasing to 26.8% and 8.78 in 2009. IgG4 anti-SEA reactivity in infected individuals was significantly higher than that in uninfected individuals at all time points. Analysis of receiver-operating characteristic (ROC) area showed that the IgG4 anti-SEA antibodies were able to predict infection by S. mansoni at each time point. CONCLUSION:IgG4 anti-SEA reactivity can be used as a biomarker for immune monitoring of the presence of infection with S. mansoni in endemic areas.
journal_name
Trans R Soc Trop Med Hygauthors
Matoso LF,Oliveira-Prado R,Abreu MN,Fujiwara RT,Loverde PT,Kloos H,Gazzinelli A,Correa-Oliveira Rdoi
10.1093/trstmh/trt091subject
Has Abstractpub_date
2013-12-01 00:00:00pages
797-805issue
12eissn
0035-9203issn
1878-3503pii
trt091journal_volume
107pub_type
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
abstract::Alpha-feto protein (alpha-FP) is now accepted as a very useful serum marker of hepatocarcinoma, and since its discovery in 1963, surveys have been carried out in various regions of the world, where hepatoma is particularly prevalent, which have shown that alpha-FP may be detected in 50 to 80% of patients with liver ca...
journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:2013-05-01 00:00:00
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
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abstract::Polymerase chain reaction (PCR) is now widely used in malaria research for analysis of field samples. However, little has been reported regarding loss of sensitivity due to field methodology. Therefore, studies were carried out in relation to blood sampling (anticoagulants, culture medium, filter paper), storage (temp...
journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,多中心研究
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journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章
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更新日期:1987-01-01 00:00:00
abstract::The red fox is considered to be the main reservoir of the present European rabies epizootic which began in Poland in 1939-40. Its usual rate of spread is 20 to 60 km a year. Mortality among rabies-infected fox populations is estimated variously to be 20 to 60%. The infection spreads more rapidly among foxes in the aut...
journal_title:Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type: 杂志文章,评审
doi:10.1016/0035-9203(76)90036-5
更新日期:1976-01-01 00:00:00