当前位置： SCI文献检索 > TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE期刊下所有文献 > Pilot study of sodium phenylbutyrate as adjuvant in cyclophosphamide-resistant endemic Burkitt's lymphoma.

Pilot study of sodium phenylbutyrate as adjuvant in cyclophosphamide-resistant endemic Burkitt's lymphoma.

Abstract：

:Burkitt's lymphoma (BL) accounts for the majority of childhood malignancies seen in sub-Saharan Africa. In Malawi, cyclophosphamide (CPM), the mainstay of treatment for endemic BL, is effective in around 50% of cases. Evidence exists in support of an association between activation of replication of Epstein-Barr virus (EBV) in the tumour and response to this chemotheraupeutic agent. Phenylbutyrate (PB), approved for treatment of inborn errors of the urea cycle with minimal toxicity in children, induces EBV replication and cell lysis in BL-derived cell cultures. It has also shown some success as adjuvant in treatment of chronic leukaemia and lymphoma. We tested in African BL patients with CPM-resistant tumours, and thus unlikely to survive, the hypothesis that PB can reverse this resistance. A study of five patients showed PB before CPM to induce shrinkage of CPM-resistant tumours in two of them. Findings suggested that for this effect PB pre-treatment should be given for a week before CPM treatment. A larger study is indicated.

journal_name

Trans R Soc Trop Med Hyg

journal_title

Transactions of the Royal Society of Tropical Medicine and Hygiene

authors

Phillips JA,Griffin BE

doi

10.1016/j.trstmh.2007.06.020

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

1265-9

issue

12

eissn

0035-9203

issn

1878-3503

pii

S0035-9203(07)00247-7

journal_volume

101

pub_type

杂志文章

相关文献

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE文献大全
  • Maggot infestation (myiasis) of external fixation pin sites in diabetic patients.

    abstract：:Diabetic patients, and especially elderly patients in a low-nutritional or immunocompromised state, are prone to a variety of opportunistic infections. 'Myiasis' is a term that refers to non-iatrogenic infestation of tissues by larvae, commonly known as maggots, of dipterous flies. Myiasis as a complication of fractur...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2008.05.011

    authors： Verettas DA,Chatzipapas CN,Drosos GI,Xarchas KC,Staikos C,Chloropoulou P,Kazakos KI,Ververidis A

    更新日期：2008-09-01 00:00:00

  • Clinical features cannot predict a diagnosis of malaria or differentiate the infecting species in children living in an area of low transmission.

    abstract：:The differentiation of malaria from other causes of fever in the absence of microscopy is notoriously difficult. Clinical predictors of malaria have been studied in an area of low and unstable transmission on the western border of Thailand. In 1527 children aged 2-15 years who were followed prospectively for 7 months,...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(98)90950-6

    authors： Luxemburger C,Nosten F,Kyle DE,Kiricharoen L,Chongsuphajaisiddhi T,White NJ

    更新日期：1998-01-01 00:00:00

  • Dynamics of schistosoma haematobium infection in a Gambian community. II. The effect on transmission of the control of Bulinus senegalensis by the use of niclosamide.

    abstract：:Niclosamide was used to interrupt transmission of Schistosoma haematobium by Bulinus senegalensis in seasonal rainwater pools for a period of three years. Snail populations were progressively reduced to approximately 1% of the numbers in untreated pools. There was little or no evidence of acquisition of new infection ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(84)90282-7

    authors： Goll PH,Wilkins HA,Marshall TF

    更新日期：1984-01-01 00:00:00

  • The ecology and epidemiology of Ross River and Murray Valley encephalitis viruses in Western Australia: examples of One Health in Action.

    abstract：:Arboviruses are maintained and transmitted through an alternating biological cycle in arthropods and vertebrates, with largely incidental disease in humans and animals. As such, they provide excellent examples of One Health, as their health impact is inextricably linked to their vertebrate hosts, their arthropod vecto...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/trx045

    authors： Mackenzie JS,Lindsay MDA,Smith DW,Imrie A

    更新日期：2017-06-01 00:00:00

  • Epidemic dropsy following transcutaneous absorption of Argemone mexicana oil.

    abstract：:Four cases manifesting features characteristic of epidemic dropsy following body massage with contaminated mustard oil are reported. A transcutaneous route of absorption for the toxin (sanguinarine) resulting in epidemic dropsy has not been documented previously in man. Oil used for body massage was found to be adulte...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(85)90079-3

    authors： Sood NN,Sachdev MS,Mohan M,Gupta SK,Sachdev HP

    更新日期：1985-01-01 00:00:00

  • Serological differentiation between past and present infection in hepatic amoebiasis.

    abstract：:The indirect fluorescent antibody (IFA) test and the amoebic gel diffusion (AGD) test were assessed as tools for differentiating between past and present infection in invasive amoebiasis; in the case of the IFA test the Entamoeba histolytica-specific IgG and IgM were monitored. In a pilot study in which sera from 56 p...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(84)90115-9

    authors： Jackson TF,Anderson CB,Simjee AE

    更新日期：1984-01-01 00:00:00

  • Aerosol immunisation for TB: matching route of vaccination to route of infection.

    abstract：:TB remains a very significant global health burden. There is an urgent need for better tools for TB control, which include an effective vaccine. Bacillus Calmette-Guérin (BCG), the currently licensed vaccine, confers highly variable protection against pulmonary TB, the main source of TB transmission. Replacing BCG com...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章,评审

    doi：10.1093/trstmh/tru206

    authors： Manjaly Thomas ZR,McShane H

    更新日期：2015-03-01 00:00:00

  • Hepatitis B assessment without hepatitis B virus DNA quantification: a prospective cohort study in Uganda.

    abstract：Background:Chronic hepatitis B infection affects 240 million people, with the highest prevalence in Africa and Asia, and results in 700 000 deaths annually. Access to diagnostics, particularly for hepatitis B virus viral load quantification (HBV DNA), is a major barrier to treatment. We aimed to test World Health Organ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/try117

    authors： Laing N,Tufton H,Ochola E,P'Kingston OG,Maini MK,Easom N

    更新日期：2019-01-01 00:00:00

  • Breath hydrogen concentrations after oral lactose and lactulose in tropical malabsorption and adult hypolactasia.

    abstract：:Thirty-six hospital in-patients in London had breath-hydrogen concentrations measured after 50 g lactose were given orally; in 23 or them serial blood glucose concentrations were also estimated. Eight had tropical malabsorption (TM), 14 were Europeans with no detectable disease (normal group) and 14 who also had no de...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(78)90208-0

    authors： Cook GC

    更新日期：1978-01-01 00:00:00

  • Morbidity and mortality of wild animals in relation to outbreaks of Ebola haemorrhagic fever in Gabon, 1994-2003.

    abstract：:Antibody to Ebola virus was found in 14 (1.2%) of 1147 human sera collected in Gabon in 1981-1997. Six seropositive subjects were bled in the northeast in 1991, more than 3 years prior to recognition of the first known outbreak of Ebola haemorrhagic fever (EHF), whilst eight came from the southwest where the disease h...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2006.07.002

    authors： Lahm SA,Kombila M,Swanepoel R,Barnes RF

    更新日期：2007-01-01 00:00:00

  • Quantifying the physical and socio-economic burden of filarial lymphoedema in Chikwawa District, Malawi.

    abstract：BACKGROUND:Lymphatic filariasis (LF) is a disfiguring parasitic disease and one of the leading causes of disability in the world. This study aimed to assess the severity of lymphoedema, the physical restrictions and socio-economic impact on affected individuals living in an endemic community in Malawi. METHODS:In a si...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/tru154

    authors： Martindale S,Mkwanda SZ,Smith E,Molyneux D,Stanton MC,Kelly-Hope LA

    更新日期：2014-12-01 00:00:00

  • Direct isolation in vitro of Trypanosoma brucei from man and other animals, and its potential value for the diagnosis of gambian trypanosomiasis.

    abstract：:A recently described simple kit for isolating African trypanosomes in vitro (KIVI) was tested further with blood samples from man and other animals in Côte d'Ivoire and République du Congo. A high rate of success was achieved, with positive cultures being found 5-36 d after inoculation. The method was also of value in...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(92)90158-9

    authors： Truc P,Aerts D,McNamara JJ,Claes Y,Allingham R,Le Ray D,Godfrey DG

    更新日期：1992-11-01 00:00:00

  • Mortality in a seven-and-a-half-year follow-up of a trial of insecticide-treated mosquito nets in Ghana.

    abstract：:A 17% efficacy in preventing all-cause mortality in children aged 6-59 months was previously reported from a cluster-randomized controlled trial of insecticide-treated mosquito nets (ITNs) carried out in the Kassena-Nankana District of northern Ghana from July 1993-June 1995. A follow-up until the end of 2000 found no...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0035-9203(02)90321-4

    authors： Binka FN,Hodgson A,Adjuik M,Smith T

    更新日期：2002-11-01 00:00:00

  • Cockroaches as carriers of human intestinal parasites in two localities in Ethiopia.

    abstract：:A study was undertaken to assess the role of cockroaches as potential carriers of human intestinal parasites in Addis Ababa and Ziway, Ethiopia. A total of 6480 cockroaches were trapped from the two localities from October 2006 to March 2007. All the cockroaches trapped in Addis Ababa (n=2240) and almost 50% (2100/424...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2008.05.009

    authors： Kinfu A,Erko B

    更新日期：2008-11-01 00:00:00

  • An indirect haemagglutination reaction for the demonstration of Schistosoma mansoni circulating anodic antigen.

    abstract：:Using the IgG fraction of a monospecific sheep antiserum against the circulating anodic antigen (CAA) of Schistosoma mansoni, an indirect haemagglutination reaction for the determination of this antigen was developed. This is the first time that an IHA has been applied to the detection of circulating antigens in paras...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(78)90055-x

    authors： Deelder AM,Eveleigh PC

    更新日期：1978-01-01 00:00:00

  • Impact of four years of large-scale ivermectin treatment with low therapeutic coverage on the transmission of Onchocerca volvulus in the Mbam valley focus, central Cameroon.

    abstract：:The extent to which ivermectin treatments have an impact on onchocerciasis transmission is a matter of some concern. We investigated this issue in the Mbam valley, a hyperendemic focus located in a forest-savannah mosaic area of Cameroon. Parasitological examinations of 5-9-year-old children, who had never received an...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2003.11.010

    authors： Pion SD,Clément MC,Boussinesq M

    更新日期：2004-09-01 00:00:00

  • Epidemiological investigation of Taenia solium taeniasis and cysticercosis in a rural village of Michoacan state, Mexico.

    abstract：:We performed a survey for taeniasis and cysticercosis among persons living in a Mexican village where Taenia solium infection in pigs was known to be enzootic. A standardized questionnaire was administered in all 577 households to obtain medical histories and information on demographic and environmental factors and on...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(94)90493-6

    authors： Sarti E,Schantz PM,Plancarte A,Wilson M,Gutierrez OI,Aguilera J,Roberts J,Flisser A

    更新日期：1994-01-01 00:00:00

  • Cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis in Amazonian Brazil, and the significance of a negative Montenegro skin-test in human infections.

    abstract：:The clinical and epidemiological features of 62 cases of cutaneous leishmaniasis due to Leishmania (Leishmania) amazonensis, from Pará State, Amazonian Brazil, are discussed. The parasite, isolated in hamster skin and/or blood-agar culture medium, was in each case identified by both biological characteristics and a mo...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(91)90437-4

    authors： Silveira FT,Lainson R,Shaw JJ,De Souza AA,Ishikawa EA,Braga RR

    更新日期：1991-11-01 00:00:00

  • A quantitative approach to the relationship between Wuchereria bancrofti microfilaria counts by venous blood filtration and finger-prick blood films.

    abstract：:Counts of nocturnally periodic Wuchereria bancrofti microfilariae (mf) in 20 mm3 finger-prick blood films were compared with membrane counts after filtration of 1 ml of venous blood for their efficacy in determining the prevalence of Bancroftian filariasis. The technique used for spreading and staining the blood films...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(91)90237-s

    authors： Sabry M

    更新日期：1991-07-01 00:00:00

  • Effect of pyrimethamine and sulphadoxine on human lymphocyte proliferation.

    abstract：:The in vitro effect of pyrimethamine (PYR) on human blood mononuclear cells stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivative of tuberculin (PPD) was studied by 14C-thymidine incorporation, by cell counting and by total DNA estimation. PYR in concentrations 10 times high...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(86)90040-4

    authors： Bygbjerg IC,Odum N,Theander TG

    更新日期：1986-01-01 00:00:00

  • Leishmaniasis in Brazil. XIV. Leishmanial and trypanosomal IgA antibody in patients with leishmaniasis and Chagas's disease.

    abstract：:Preserved sera from patients with various forms of leishmaniasis, acute and chronic Chagas's disease and from normal individuals were examined for the presence of IgG and IgA antibodies by the IFA test. The leishmanial antigen used in the IFA test was prepared from a hamster infected with the PH8 strain of Leishmania ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(81)90329-1

    authors： Shaw JJ,Lainson R

    更新日期：1981-01-01 00:00:00

  • Medicinal plants and Malaria: an historical case study of research at the London School of Hygiene and Tropical Medicine in the twentieth century.

    abstract：:Interest in medicinal plants has increased in recent years. This article examines the history of medicinal plant research through a case study of the London School of Hygiene and Tropical Medicine (LSHTM) over the past 100 years. Papers published by members of the School and documents in the School archives show a flu...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/j.trstmh.2005.11.017

    authors： Taylor S,Berridge V

    更新日期：2006-08-01 00:00:00

  • Multiplex real-time PCR for the detection and quantification of Schistosoma mansoni and S. haematobium infection in stool samples collected in northern Senegal.

    abstract：:A multiplex real-time PCR assay for the detection and quantification of Schistosoma mansoni and S. haematobium DNA in faecal samples was developed and evaluated as an alternative diagnostic method to study the epidemiology of schistosomiasis. Primers and probes targeting the cytochrome c oxidase gene were designed for...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2007.10.011

    authors： ten Hove RJ,Verweij JJ,Vereecken K,Polman K,Dieye L,van Lieshout L

    更新日期：2008-02-01 00:00:00

  • Impact of sputum quality and quantity on smear and culture positivity: findings from a tuberculosis prevalence study in central India.

    abstract：BACKGROUND:The objective of this study was to assess the impact of sputum quality and quantity on smear and culture positivity for Mycobacterium tuberculosis. METHODS:A total of 14 708 sputum specimens, collected from respiratory symptomatics in a TB prevalence survey, were evaluated for gross appearance and volume of...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/trt100

    authors： Bhat J,Rao V,Muniyandi M,Yadav R,Karforma C,Luke C

    更新日期：2014-01-01 00:00:00

  • Direct identification of Leishmania species in biopsies from patients with American tegumentary leishmaniasis.

    abstract：:Accurate identification of Leishmania species is important for monitoring clinical outcome, adequately targeting treatment, and evaluation of epidemiological risk in tegumentary leishmaniasis. This is especially the case in regions where several species coexist and for travel medicine where the geographical source of ...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/s0035-9203(03)90031-9

    authors： Victoir K,De Doncker S,Cabrera L,Alvarez E,Arevalo J,Llanos-Cuentas A,Le Ray D,Dujardin JC

    更新日期：2003-01-01 00:00:00

  • Mechanisms of action of lysophospholipid analogues against trypanosomatid parasites.

    abstract：:Lysophospholipid analogues (LPAs) comprise a class of metabolically stable compounds that have been developed as anticancer agents for over two decades, but which have also potent and selective antiparasitic activity, particularly against trypanosomatid parasites such as Leishmania and Trypanosoma cruzi, both in vitro...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章,评审

    doi：10.1016/j.trstmh.2006.03.010

    authors： Urbina JA

    更新日期：2006-12-01 00:00:00

  • Non-bacterial etiologies of diarrheal diseases in Afghanistan.

    abstract：BACKGROUND:Microbial diarrheal diseases are one of the leading causes of child morbidity and mortality in developing countries. This study aimed to identify the main causes of non-bacterial diarrhea in Afghanistan. METHODS:A total of 699 stools were collected from children aged under 5 years who presented with diarrhe...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/tru096

    authors： Elyan D,Wasfy M,El Mohammady H,Hassan K,Monestersky J,Noormal B,Oyofo B

    更新日期：2014-08-01 00:00:00

  • Disability, mental health, stigma and discrimination and neglected tropical diseases.

    abstract：:The neglected tropical disease (NTD) agenda should include a focus on disability when 'planning for the next decade of progress'. Millions of people are currently living with the disabling consequences of NTDs and mental health conditions are frequent among people living with NTDs. Stigma around NTDs is also common. H...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1093/trstmh/traa160

    authors： Kuper H

    更新日期：2020-12-12 00:00:00

  • A sero-epidemiological survey of asymptomatic cases of Boutonneuse fever in western Sicily.

    abstract：:963 sera from contacts, persons from various localities, and blood donors were examined with a commercially produced kit for micro-immunofluorescence for the presence of antibodies to Rickettsia conorii. 10.6% of sera were serologically positive. The higher rates of positivity were observed in sera of contacts (19%) a...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/0035-9203(84)90163-9

    authors： Mansueto S,Vitale G,Miceli MD,Tringali G,Quartararo P,Picone DM,Occhino C

    更新日期：1984-01-01 00:00:00

  • Plasmodium knowlesi infections in a small number of non-immune natural hosts (Macaca fascicularis) and in rhesus monkeys (M. mulatta).

    abstract：:The natural host of Plasmodium knowlesi is the kra monkey, Macaca fascicularis, but this parasite, initially mistaken for P. malariae, is now infecting humans in some areas of Southeast Asia. Here we present data from experiments performed in the 1970s in which sera from a few naive M. fascicularis, taken in the cours...

    journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene

    pub_type： 杂志文章

    doi：10.1016/j.trstmh.2009.05.017

    authors： Butcher GA,Mitchell GH,Cohen S

    更新日期：2010-01-01 00:00:00