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Effect of ovariectomy on contrast agent diffusion into lumbar intervertebral disc: a dynamic contrast-enhanced MRI study in female rats.

Abstract：

PURPOSE:The purpose was to study the effect of estrogen deficiency on contrast agent diffusion into intervertebral disc in a rat model. MATERIALS AND METHODS:Seven-month-old female Sprague-Dawley rats were used. Fourteen rats had ovariectomy, and nine rats had sham surgery. Magnetic resonance imaging (MRI) of sagittal midsection of lumbar spine was performed with a 1.5-T magnet. Dynamic MRI was performed after a bolus injection of Gd-DOTA (0.3 mmol/kg) through tail vein. Eight hundred images were acquired at 0.6 s per acquisition. Regions of interests were drawn over three discs per rat. Maximum enhancement (E(max)) and enhancement slope (E(slope)) were evaluated. MRI was carried out at baseline and 8 weeks postsurgery. RESULT:All disc enhancements demonstrated an initial fast wash-in phase followed by a second slower wash-in phase. For initial wash-in phase, E(1)(max) and E(1)(slope) of all rats remained unchanged at the two time points. For second wash-in phase, E(2)(max) and E(2)(slope) of control rats remained unchanged, while with ovariectomized rats, E(2)(max) showed reduction at 8 weeks (4.5%±5.6%) compared to baseline (10.3%±6.3%, P=.037), and E(2)(slope) was lower at 8 weeks (0.015±0.017) than the baseline (0.029±0.022), although it was not statistically significant (P=.101). CONCLUSION:Ovariectomy induced detectable decrease in second wash-in phase of contrast agent into lumbar disc.

journal_name

Magn Reson Imaging

journal_title

Magnetic resonance imaging

authors

Deng M,Griffith JF,Zhu XM,Poon WS,Ahuja AT,Wang YX

doi

10.1016/j.mri.2012.01.001

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

683-8

issue

5

eissn

0730-725X

issn

1873-5894

pii

S0730-725X(12)00037-9

journal_volume

30

pub_type

杂志文章

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