Abstract:
:Functional magnetic resonance imaging (fMRI) based on the so-called blood oxygen level-dependent (BOLD) contrast is a powerful tool for studying brain function not only locally but also on the large scale. Most studies assume a simple relationship between neural and BOLD activity, in spite of the fact that it is important to elucidate how the "when" and "what" components of neural activity are correlated to the "where" of fMRI data. Here we conducted simultaneous recordings of neural and BOLD signal fluctuations in primary visual (V1) cortex of anesthetized monkeys. We explored the neurovascular relationship during periods of spontaneous activity by using temporal kernel canonical correlation analysis (tkCCA). tkCCA is a multivariate method that can take into account any features in the signals that univariate analysis cannot. The method detects filters in voxel space (for fMRI data) and in frequency-time space (for neural data) that maximize the neurovascular correlation without any assumption of a hemodynamic response function (HRF). Our results showed a positive neurovascular coupling with a lag of 4-5 s and a larger contribution from local field potentials (LFPs) in the γ range than from low-frequency LFPs or spiking activity. The method also detected a higher correlation around the recording site in the concurrent spatial map, even though the pattern covered most of the occipital part of V1. These results are consistent with those of previous studies and represent the first multivariate analysis of intracranial electrophysiology and high-resolution fMRI.
journal_name
Magn Reson Imagingjournal_title
Magnetic resonance imagingauthors
Murayama Y,Biessmann F,Meinecke FC,Müller KR,Augath M,Oeltermann A,Logothetis NKdoi
10.1016/j.mri.2009.12.016subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1095-103issue
8eissn
0730-725Xissn
1873-5894pii
S0730-725X(09)00308-7journal_volume
28pub_type
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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更新日期:1998-11-01 00:00:00
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更新日期:1995-01-01 00:00:00
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更新日期:2014-12-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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doi:10.1016/s0730-725x(98)00099-x
更新日期:1999-02-01 00:00:00
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更新日期:2021-01-22 00:00:00
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pub_type: 杂志文章
doi:10.1016/0730-725x(93)90035-c
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/j.mri.2005.10.013
更新日期:2006-02-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2007.02.014
更新日期:2007-07-01 00:00:00
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journal_title:Magnetic resonance imaging
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doi:10.1016/j.mri.2006.03.012
更新日期:2006-09-01 00:00:00
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journal_title:Magnetic resonance imaging
pub_type: 杂志文章
doi:10.1016/0730-725x(91)90095-4
更新日期:1991-01-01 00:00:00
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journal_title:Magnetic resonance imaging
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journal_title:Magnetic resonance imaging
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更新日期:2017-01-01 00:00:00
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