Abstract:
:We seek to construct physical and mathematical models of life. Such models allow us to test our understanding of how living systems function and how they respond to human imposed stimuli. One system is a genomically and chemically complete model of a minimal cell. This cell is a hypothetical bacterium with the fewest number of genes possible. Such a minimal cell provides a platform to ask about the essential features of a living cell and forms a platform to investigate "synthetic biology." A second system is "Body-on-a-Chip" which is a microfabricated microfluidic system with cells or tissue constructs representing various organs in the body. It can be constructed from human or animal cells and used in drug discovery development. That model is a physical representation of a physiologically based pharmacokinetic model. Both the computer and the physical models provide insight into the underlying biology and provide new tools to make use of that understanding to provide benefits to society.
journal_name
Ann Biomed Engjournal_title
Annals of biomedical engineeringauthors
Shuler MLdoi
10.1007/s10439-012-0567-7subject
Has Abstractpub_date
2012-07-01 00:00:00pages
1399-407issue
7eissn
0090-6964issn
1573-9686journal_volume
40pub_type
杂志文章,评审abstract::This study is aimed at refining our understanding of the role of vortex formation at mitral mechanical heart valve (MHV) closure and its association with the high intensity transient signals (HITS) seen in echocardiographic studies with MHV recipients. Previously reported numerical results described a twofold process ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-007-9293-y
更新日期:2007-07-01 00:00:00
abstract::The compression of blood vessels by surrounding tissue is an important problem in hemodynamics, most prominently in studies relating to the heart. In this study we consider a long tube of elliptic cross section as an idealization of the geometry of a compressed blood vessel. An exact solution of the governing equation...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.106
更新日期:1998-09-01 00:00:00
abstract::Continuous gradients exist at osteochondral interfaces, which may be engineered by applying spatially patterned gradients of biological cues. In the present study, a protein-loaded microsphere-based scaffold fabrication strategy was applied to achieve spatially and temporally controlled delivery of bioactive signals i...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0028-0
更新日期:2010-06-01 00:00:00
abstract::Asymmetric 75% and 95% area reduction, transparent Sylgard stenotic models were operated under internal carotid artery (ICA) [Womersley parameter, alpha=5.36, Re(mean) =213 and 180, respectively, and Re(peak)=734 and 410, respectively] and left anterior descending coronary artery (LAD) flow wave forms (alpha=2.65, Re(...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.131
更新日期:1998-03-01 00:00:00
abstract::There is a significant clinical need for engineered bone graft substitutes that can quickly, effectively, and safely repair large segmental bone defects. One emerging field of interest involves the growth of engineered bone tissue in vitro within bioreactors, the most promising of which are perfusion bioreactors. Usin...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-016-1662-y
更新日期:2016-12-01 00:00:00
abstract::Gas transfer through hollow fiber membranes (HFMs) can be increased via fiber oscillation. Prior work, however, does not directly translate to present-day, full-scale artificial lungs. This in vitro study characterized the effects of HFM oscillations on oxygenation and hemolysis for a pediatric-sized HFM bundle. Effec...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-018-1995-9
更新日期:2018-05-01 00:00:00
abstract::Percutaneous stent implantation has revolutionized the clinical treatment of occluded arteries. Nevertheless, there is still a large unmet need to prevent re-occlusion after implantation. Consequently, a niche exists for a cost-effective pre-clinical method of evaluating novel interventional devices in human models. T...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9701-6
更新日期:2009-07-01 00:00:00
abstract::The induction of angiogenesis is a promising therapeutic strategy for the amelioration of peripheral arterial disease (PAD). This occlusive disease results in muscle ischemia, and neovascularization is a route to increasing the perfusion in the tissue. The vascular endothelial growth factor (VEGF) family of potent pro...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-007-9303-0
更新日期:2007-06-01 00:00:00
abstract::User preferences need to be taken into account in order to be able to design devices that will gain acceptance both in a clinical and home setting. Sensor systems become redundant if patients or clinicians do not want to work with them. The aim of this systematic review was to determine both patients' and clinicians' ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-011-0339-9
更新日期:2011-09-01 00:00:00
abstract::An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/b:abme.0000036650.32345.b6
更新日期:2004-08-01 00:00:00
abstract::It is proposed that the maximum in cuff pressure oscillations during oscillometry is due to the buckling of the brachial artery under a cuff. This theory is investigated by means of a mathematical model of oscillatometry that includes the mechanics of the occlusive arm cuff, the arterial pressure pulse waveform, and t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368225
更新日期:1994-01-01 00:00:00
abstract::Electromechanical reshaping (EMR) of cartilage provides an alternative to the classic surgical techniques of modifying the shape of facial cartilages. The original embodiment of EMR required surface electrodes to be in direct contact with the entire cartilage region being reshaped. This study evaluates the feasibility...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-0088-1
更新日期:2010-11-01 00:00:00
abstract::The human thorax is commonly injured in motor vehicle crashes, and despite advancements in occupant safety rib fractures are highly prevalent. The objective of this study was to quantify the ability of gross and cross-sectional geometry, separately and in combination, to explain variation of human rib structural prope...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1007/s10439-017-1850-4
更新日期:2017-09-01 00:00:00
abstract::The linear homeomorphic muscle model proposed by Enderle and coworkers for the rectus eye muscle is fitted to reflect the dynamics of muscles in the head-neck complex, specifically in muscles involved in gaze shifts. This parameterization of the model for different muscles in the neck region will serve to drive a 3D d...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-009-9851-6
更新日期:2010-02-01 00:00:00
abstract::The oscillometric fixed-ratio method is widely employed for non-invasive measurement of systolic and diastolic pressures (SP and DP) but is heuristic and prone to error. We investigated the accuracy of this method using an established mathematical model of oscillometry. First, to determine which factors materially aff...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-012-0700-7
更新日期:2013-03-01 00:00:00
abstract::Of the many models of peripheral nerve in the literature, essentially all have relied on experimentally derived values for the anisotropic resistivity of the nerve bundle interstitial space. This paper is a comprehensive mathematical analysis of the most referenced experiment for the longitudinal and radial resistivit...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02368054
更新日期:1989-01-01 00:00:00
abstract::Image registration and motion estimation play central roles in many fields, including RADAR, SONAR, light microscopy, and medical imaging. Because of its central significance, estimator accuracy, precision, and computational cost are of critical importance. We have previously presented a highly accurate, spline-based ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9564-2
更新日期:2008-12-01 00:00:00
abstract::The traditional auscultatory technique and current methodologies for measuring human blood pressure are limited when used in situations where extreme vibration or acoustic noise is present. In this study, human subjects were used to establish the effectiveness of a novel adaptive blood pressure monitoring (ABPM) syste...
journal_title:Annals of biomedical engineering
pub_type: 临床试验,杂志文章
doi:10.1114/1.1481051
更新日期:2002-05-01 00:00:00
abstract::The signal that governs the chemotactic response of mammalian white blood cells and tissue cells arises from membrane-localized binding events involving chemotactic factor ligands and receptors and G proteins. Fluctuations in this signal have been traditionally attributed to significant "noise" in receptor-ligand bind...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/BF02584427
更新日期:1995-05-01 00:00:00
abstract::This is a personal historical essay on meanderings through the jungle of the microcirculatory swamp. Because one pretends that the wandering was purposefully exploratory, a few guideposts are placed at positions where one could discern blaze-marks from earlier wanderers, and the path cut a little wider along some of t...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/BF02363568
更新日期:1987-01-01 00:00:00
abstract::An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study was to develop a constitutive model of the stress-strain behavior of the human...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-008-9555-3
更新日期:2008-11-01 00:00:00
abstract::Upon nerve injury, the body creates an environment consisting of permissive and non-permissive cues that instruct the function of cells involved in nerve repair. Among other roles, the developing extracellular matrix (ECM) acts as an underlying substrate to guide the union of neurites extending from the proximal stump...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-014-0991-y
更新日期:2014-06-01 00:00:00
abstract::The contractile power of the latissimus dorsi muscle (LDM) is used in skeletal muscle cardiac assist (SMCA) to augment the blood pumping ability of a failing heart. The LDM has three anatomically distinct, independently innervate segments-the transverse, oblique, and lateral. There are potential advantages to selectiv...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1114/1.164
更新日期:1999-01-01 00:00:00
abstract::Current efforts to evaluate the performance of laparoscopic arterial fusion devices are limited to costly, time consuming, empirical studies. Thus, a finite element (FE) model, with the ability to predict device performance would improve device design and reduce development time and costs. This study introduces a mode...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-016-1588-4
更新日期:2016-11-01 00:00:00
abstract::Arterial tissue is commonly assumed to be incompressible. While this assumption is convenient for both experimentalists and theorists, the compressibility of arterial tissue has not been rigorously investigated. In the current study we present an experimental-computational methodology to determine the compressibility ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-015-1417-1
更新日期:2016-04-01 00:00:00
abstract::"Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated parti...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000030255.36748.d3
更新日期:2004-06-01 00:00:00
abstract::Much effort is expended in developing biomimetic scaffolds that provide the micro-architecture of native tissue with appropriate cellular niches. Such scaffolds are often seeded with progenitor cells to generate engineered replacements for diseased or damaged tissues. An alternative approach relies on biology, rather ...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章,评审
doi:10.1007/s10439-014-1174-6
更新日期:2015-03-01 00:00:00
abstract::Bending stiffness of passive-dynamic ankle-foot orthoses (PD-AFOs) is a functional characteristic thought to restore lost ankle function due to weakened plantar flexors. However, lower extremity impairment profiles of patients are seldom limited to plantar flexion weakness, and PD-AFO characteristics often influence g...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-014-1067-8
更新日期:2015-02-01 00:00:00
abstract::The identification of the insulin minimal model (MM) for the estimation of insulin secretion rate (ISR) and physiological indexes (e.g. beta-cell sensitivity) requires the knowledge of C-peptide (CP) kinetics. The four parameters of the two-compartment model of CP kinetics in a given individual can be derived either f...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1023/b:abme.0000032465.75888.91
更新日期:2004-07-01 00:00:00
abstract::In the field of fluid flow within the human body, focus has been placed on the transportation of blood in the systemic circulation since the discovery of that system; but, other fluids and fluid flow phenomena pervade the body. Some of the most fascinating fluid flow phenomena within the human body involve fluids othe...
journal_title:Annals of biomedical engineering
pub_type: 杂志文章
doi:10.1007/s10439-010-9902-z
更新日期:2010-03-01 00:00:00