Adhesion of microfabricated particles on vascular endothelium: a parametric analysis.


:"Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated particles injected directly into the blood stream. The shape, size, and material properties of the particles can be designed and optimized depending on the specific applications and targets (cell, tissue, or circulating virus). Since the binding affinity of particles to cells is affected by both the binding force and its growth rate with time, it is of great importance to consider the viscous response of the system. In this work, a parametric analysis is presented where the probability of adhesion of a microfabricated particle on the endothelium is expressed as a function of (i) the hemodynamic conditions, (ii) the viscoelastic properties of the particle and targeted cell, and (iii) density of ligands grafted over the particle. Criteria for the optimal design of particles are proposed.


Ann Biomed Eng


Decuzzi P,Lee S,Decuzzi M,Ferrari M




Has Abstract


2004-06-01 00:00:00












  • Nonlinear dynamics of microvascular blood flow.

    abstract::Kiani et al. (Kiani, M. F., A. R. Pries, L. L. Hsu, I. H. Sarelius, and G. R. Cokelet, Am. J. Physics. 266: H1822-H1828, 1994) suggested that blood velocity, hematocrit, and nodal pressures can oscillate spontaneously in large microvascular networks in the absence of biological control. This paper presents a model of ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Carr RT,Lacoin M

    更新日期:2000-06-01 00:00:00

  • Net change in periosteal strain during stance shift loading after surgery correlates to rapid de novo bone generation in critically sized defects.

    abstract::In an ovine femur model, proliferative woven bone fills critically sized defects enveloped by periosteum within 2 weeks of treatment with the one-stage bone-transport surgery. We hypothesize that mechanical loading modulates this process. Using high-definition optical strain measurements we determined prevailing perio...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: McBride SH,Dolejs S,Brianza S,Knothe U,Knothe Tate ML

    更新日期:2011-05-01 00:00:00

  • Development of an arbitrary waveform membrane stretcher for dynamic cell culture.

    abstract::In this paper, a novel cell stretcher design that mimics the real-time stretch of the heart wall is introduced. By culturing cells under stretched conditions that mimics the mechanical aspects of the native cardiac environment, better understanding on the role of biomechanical signaling on cell development can be achi...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Lau JJ,Wang RM,Black LD 3rd

    更新日期:2014-05-01 00:00:00

  • A model of electrical conduction in cardiac tissue including fibroblasts.

    abstract::Fibroblasts are abundant in cardiac tissue. Experimental studies suggested that fibroblasts are electrically coupled to myocytes and this coupling can impact cardiac electrophysiology. In this work, we present a novel approach for mathematical modeling of electrical conduction in cardiac tissue composed of myocytes, f...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Sachse FB,Moreno AP,Seemann G,Abildskov JA

    更新日期:2009-05-01 00:00:00

  • Dynamics of cardiac period responses after prolonged vagal stimulation in the dog.

    abstract::In 12 dogs anesthetised with alpha-chloralose and urethane, and beta-adrenergic blocked with propranolol, the cervical vagi were stimulated for 60 seconds with supramaximal constant current pulses at frequencies between 2.0 and 10 Hz. The time course of the recovery of the cardiac period response, after cessation of v...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Celler BG,Lovell NH

    更新日期:1991-01-01 00:00:00

  • Effects of Chemically Doped Bioactive Borate Glass on Neuron Regrowth and Regeneration.

    abstract::Peripheral nerve injuries present challenges to regeneration. Currently, the gold standard for nerve repair is an autograft that results in another region of the body suffering nerve damage. Previously, bioactive borate glass (BBG) has been studied in clinical trials to treat patients with non-healing wounds, and we h...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Gupta B,Papke JB,Mohammadkhah A,Day DE,Harkins AB

    更新日期:2016-12-01 00:00:00

  • Mathematical models of the spatial distribution of retinal oxygen tension and consumption, including changes upon illumination.

    abstract::To better understand oxygen utilization by the retina, a mathematical model of oxygen diffusion and consumption in the cat outer, avascular retina was developed by analyzing previously recorded profiles of oxygen tension (PO2) as a function of retinal depth. Simple diffusion modelling of the oxygen distribution throug...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Haugh LM,Linsenmeier RA,Goldstick TK

    更新日期:1990-01-01 00:00:00

  • The transport profile of cytokines in epidermal equivalents subjected to mechanical loading.

    abstract::Pressure ulcer risk assessment might be optimized by incorporating the soft tissue reaction to mechanical loading in the currently used risk assessment scales. Cytokines, like IL-1alpha, IL-1RA, IL-8, and TNF-alpha, might be used to determine this tissue reaction, since they are released after 24 h of mechanical loadi...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Cornelissen LH,Bronneberg D,Bader DL,Baaijens FP,Oomens CW

    更新日期:2009-05-01 00:00:00

  • Permeability of endothelial and astrocyte cocultures: in vitro blood-brain barrier models for drug delivery studies.

    abstract::The blood-brain barrier (BBB) is a major obstacle for drug delivery to the brain. To seek for in vitro BBB models that are more accessible than animals for investigating drug transport across the BBB, we compared four in vitro cultured cell models: endothelial monoculture (bEnd3 cell line), coculture of bEnd3 and prim...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Li G,Simon MJ,Cancel LM,Shi ZD,Ji X,Tarbell JM,Morrison B 3rd,Fu BM

    更新日期:2010-08-01 00:00:00

  • Sensor Anchoring Improves the Correlation Between Intramuscular Pressure and Muscle Tension in a Rabbit Model.

    abstract::Intramuscular pressure (IMP) shows promise for estimating individual muscle tension in vivo. However, previous pressure measurements show high variability during isometric contraction and poor correlation with tension during dynamic contraction. We hypothesized that enhanced sensor anchoring/orientation would improve ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: O'Connor SM,Kaufman KR,Ward SR,Lieber RL

    更新日期:2021-02-01 00:00:00

  • Extracellular potentials and currents of a single active fiber in a restricted volume conductor.

    abstract::Based on mathematical expressions governing the electric field, the extracellular potentials generated by a single active fiber in a restricted circular cylindrical volume conductor are evaluated. This paper examines the effect of the extent of the volume conductor, with radius b, on the extracellular potentials at di...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Trayanova N,Henriquez CS,Plonsey R

    更新日期:1990-01-01 00:00:00

  • Concussion Risk Between Individual Football Players: Survival Analysis of Recurrent Events and Non-events.

    abstract::Concussion tolerance and head impact exposure are highly variable among football players. Recent findings highlight that head impact data analyses need to be performed at the subject level. In this paper, we describe a method of characterizing concussion risk between individuals using a new survival analysis technique...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rowson S,Campolettano ET,Duma SM,Stemper B,Shah A,Harezlak J,Riggen L,Mihalik JP,Brooks A,Cameron KL,Svoboda SJ,Houston MN,McAllister T,Broglio S,McCrea M

    更新日期:2020-11-01 00:00:00

  • Evaluation of three animal models for concussion and serious brain injury.

    abstract::Three animal models were evaluated in this study involving head impacts of the rat, including the Marmarou drop-weight and two momentum-exchange techniques. In series 1, 36 Wistar rats were hit on the side of the free-moving head using Marmarou's 450 g impact mass at 4.4, 5.4, and 6.3 m/s. Head acceleration was measur...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Viano DC,Hamberger A,Bolouri H,Säljö A

    更新日期:2012-01-01 00:00:00

  • 3D Printed Vascular Networks Enhance Viability in High-Volume Perfusion Bioreactor.

    abstract::There is a significant clinical need for engineered bone graft substitutes that can quickly, effectively, and safely repair large segmental bone defects. One emerging field of interest involves the growth of engineered bone tissue in vitro within bioreactors, the most promising of which are perfusion bioreactors. Usin...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Ball O,Nguyen BB,Placone JK,Fisher JP

    更新日期:2016-12-01 00:00:00

  • Shear modulus of elasticity of the esophagus.

    abstract::Experimental and diagnostic procedures like distension of a balloon catheter, bougie, and esophagogastroduodenoscopy can induce shear deformation in the esophageal wall. However, the shear modulus of the esophagus is yet unknown. The aim of this study was to determine the esophageal shear modulus and its dependence on...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Yang J,Liao D,Zhao J,Gregersen H

    更新日期:2004-09-01 00:00:00

  • Breathing resistance and ultrafine particle deposition in nasal-laryngeal airways of a newborn, an infant, a child, and an adult.

    abstract::As a human grows from birth to adulthood, both airway anatomy and breathing conditions vary, altering the deposition rate and pattern of inhaled aerosols. However, deposition studies have typically focused on adult subjects, results of which may not be readily extrapolated to children. This study numerically evaluated...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Xi J,Berlinski A,Zhou Y,Greenberg B,Ou X

    更新日期:2012-12-01 00:00:00

  • A physical model describing the mechanism for formation of gas microbubbles in patients with mitral mechanical heart valves.

    abstract::This study was aimed at developing a physical model, supported by experimental observations, to describe the formation and growth of microbubbles seen in patients with mitral mechanical heart valves (MHV). This phenomenon, often referred to as high intensity transient signals (HITS), appears as bright, intense, high-v...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Rambod E,Beizaie M,Shusser M,Milo S,Gharib M

    更新日期:1999-11-01 00:00:00

  • Myofiber ellipticity as an explanation for transverse asymmetry of skeletal muscle diffusion MRI in vivo signal.

    abstract::Due to its unique non-invasive microstructure probing capabilities, diffusion tensor imaging (DTI) constitutes a valuable tool in the study of fiber orientation in skeletal muscles. By implementing a DTI sequence with judiciously chosen directional encoding to quantify in vivo the microarchitectural properties in the ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Karampinos DC,King KF,Sutton BP,Georgiadis JG

    更新日期:2009-12-01 00:00:00

  • Probabilistic evaluation of predicted force sensitivity to muscle attachment and glenohumeral stability uncertainty.

    abstract::A major benefit of computational modeling in biomechanics research is its ability to estimate internal muscular demands given limited input information. However, several assumptions regarding model parameters and constraints may influence model outputs. This research evaluated the influence of model parameter variabil...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Chopp-Hurley JN,Langenderfer JE,Dickerson CR

    更新日期:2014-09-01 00:00:00

  • Phonocardiographic signal analysis method using a modified hidden Markov model.

    abstract::Auscultation is an important diagnostic indicator for cardiovascular analysis. Heart sound classification and analysis play an important role in the auscultative diagnosis. This study uses a combination of Mel-frequency cepstral coefficient (MFCC) and hidden Markov model (HMM) to efficiently extract the features for p...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Wang P,Lim CS,Chauhan S,Foo JY,Anantharaman V

    更新日期:2007-03-01 00:00:00

  • Increases of corporal temperature as a risk factor of atherosclerotic plaque instability.

    abstract:BACKGROUND:This work explores for the first time the effects of temperature increments on the development of high shear stresses between plaque and arterial wall due to their different dilatational properties. Data from the literature report febrile reactions prior to myocardial infarction in patients with normal coron...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Guinea GV,Atienza JM,Fantidis P,Rojo FJ,Ortega A,Torres M,Gonzalez P,Elices ML,Hayashi K,Elices M

    更新日期:2008-01-01 00:00:00

  • Design Considerations of a Fiber Optic Pressure Sensor Protective Housing for Intramuscular Pressure Measurements.

    abstract::Intramuscular pressure (IMP), defined as skeletal muscle interstitial fluid pressure, reflects changes in individual muscle tension and may provide crucial insight into musculoskeletal biomechanics and pathologies. IMP may be measured using fiber-optic fluid pressure sensors, provided the sensor is adequately anchored...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Go SA,Jensen ER,O'Connor SM,Evertz LQ,Morrow DA,Ward SR,Lieber RL,Kaufman KR

    更新日期:2017-03-01 00:00:00

  • Parameter estimation for linear compartmental models--a sensitivity analysis approach.

    abstract::Linear compartmental models are useful, explanatory tools, that have been widely used to represent the dynamic behavior of complex biological systems. This paper addresses the problem of the numerical identification of such models, i.e., the estimation of the parameter values that will generate predictions closest to ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Juillet B,Bos C,Gaudichon C,Tomé D,Fouillet H

    更新日期:2009-05-01 00:00:00

  • Vortex ring formation in the left ventricle of the heart: analysis by 4D flow MRI and Lagrangian coherent structures.

    abstract::Recent studies suggest that vortex ring formation during left ventricular (LV) rapid filling is an optimized mechanism for blood transport, and that the volume of the vortex ring is an important measure. However, due to lack of quantitative methods, the volume of the vortex ring has not previously been studied. Lagran...

    journal_title:Annals of biomedical engineering

    pub_type: 临床试验,杂志文章


    authors: Töger J,Kanski M,Carlsson M,Kovács SJ,Söderlind G,Arheden H,Heiberg E

    更新日期:2012-12-01 00:00:00

  • MUlti-Dimensional Spline-Based Estimator (MUSE) for motion estimation: algorithm development and initial results.

    abstract::Image registration and motion estimation play central roles in many fields, including RADAR, SONAR, light microscopy, and medical imaging. Because of its central significance, estimator accuracy, precision, and computational cost are of critical importance. We have previously presented a highly accurate, spline-based ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Viola F,Coe RL,Owen K,Guenther DA,Walker WF

    更新日期:2008-12-01 00:00:00

  • Two methods for calculating the responses of photoreceptors to moving objects.

    abstract::The responses of photoreceptor cells to moving stimuli are crucial to understanding motion detection in visual systems. However, these responses are not well characterized quantitatively because they result from a combination of spatial optical behavior in the lens systems with temporal behavior in the phototransducti...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Korenberg MJ,Juusola M,French AS

    更新日期:1998-03-01 00:00:00

  • Adaptive neural network that subserves optimal homeostatic control of breathing.

    abstract::An adaptive neural network model that exhibits the optimality and homeostasis characteristics of the respiratory control system is described. Based upon the Hopfield network structure and a postulated Hebb-like respiratory synapse with correlational short-term potentiation, the model is capable of mimicking the normal...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Poon CS

    更新日期:1993-09-01 00:00:00

  • Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative.

    abstract::Currently, there are no clinically available tools or applications which could predict osteoarthritis development. Some computational models have been presented to simulate cartilage degeneration, but they are not clinically feasible due to time required to build subject-specific knee models. Therefore, the objective ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Mononen ME,Liukkonen MK,Korhonen RK

    更新日期:2019-03-01 00:00:00

  • Body-worn sensor design: what do patients and clinicians want?

    abstract::User preferences need to be taken into account in order to be able to design devices that will gain acceptance both in a clinical and home setting. Sensor systems become redundant if patients or clinicians do not want to work with them. The aim of this systematic review was to determine both patients' and clinicians' ...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章,评审


    authors: Bergmann JH,McGregor AH

    更新日期:2011-09-01 00:00:00

  • The effects of anisotropy on the stress analyses of patient-specific abdominal aortic aneurysms.

    abstract::The local dilation of the infrarenal abdominal aorta, termed an abdominal aortic aneurysm (AAA), is often times asymptomatic and may eventually result in rupture-an event associated with a significant mortality rate. The estimation of in-vivo stresses within AAAs has been proposed as a useful tool to predict the likel...

    journal_title:Annals of biomedical engineering

    pub_type: 杂志文章


    authors: Vande Geest JP,Schmidt DE,Sacks MS,Vorp DA

    更新日期:2008-06-01 00:00:00